U
Ulrike Holzgrabe
Researcher at University of Würzburg
Publications - 591
Citations - 11158
Ulrike Holzgrabe is an academic researcher from University of Würzburg. The author has contributed to research in topics: Allosteric regulation & Capillary electrophoresis. The author has an hindex of 45, co-authored 566 publications receiving 9806 citations. Previous affiliations of Ulrike Holzgrabe include Jagiellonian University & University of Illinois at Chicago.
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Bisquaternary dimers of strychnine and brucine. A new class of potent enhancers of antagonist binding to muscarinic M2 receptors.
TL;DR: Bisquaternary dimers of strychnine and brucine were synthesized and their allosteric effect on muscarinic acetylcholine M(2) receptors was examined, which indicated ternary complex formation.
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Semisynthetic Analogues of Toxiferine I and Their Pharmacological Properties at α7 nAChRs, Muscle-Type nAChRs, and the Allosteric Binding Site of Muscarinic M2 Receptors
TL;DR: All ligands showed a moderate to low antagonistic effect, suggesting that the alcoholic functions are not necessary for antagonistic action and should help delineate the structural requirements for activity at different types of AChRs and for the design of novel selective ligands.
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A diversity oriented synthesis of natural product inspired molecular libraries.
TL;DR: This work leveraged the structural attributes of several natural products in building a library of architecturally diverse chiral molecules by harnessing R-tryptophan as the chiral auxiliary through a diversity oriented synthetic strategy (DOS).
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Evaluation of enantiomeric purity of magnesium-l-aspartate dihydrate
Oliver Wahl,Ulrike Holzgrabe +1 more
TL;DR: Simulations of the synthesis revealed that the d-aspartic acid content is elevated if the dissolution of L-as Partic acid was performed at acidic pH values, and the enantiomeric purity of "Magnesium aspartate dihydrate" monographed in the European Pharmacopeia was examined.
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Ugi Reaction-Derived α-Acyl Aminocarboxamides Bind to Phosphatidylinositol 3-Kinase-Related Kinases, Inhibit HSF1-Dependent Heat Shock Response, and Induce Apoptosis in Multiple Myeloma Cells
Matthias Bach,Anna Lehmann,Daniela Brünnert,Jens T. Vanselow,Andreas Hartung,Ralf C. Bargou,Ulrike Holzgrabe,Andreas Schlosser,Manik Chatterjee +8 more
TL;DR: Treatment with the anti-HSF1 compounds strongly induced apoptotic cell death in MM cells, showing that direct therapeutic targeting of HSF1 function seems to be difficult due to the shortage of clinically suitable pharmacological inhibitors.