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Ulrike Holzgrabe
Researcher at University of Würzburg
Publications - 591
Citations - 11158
Ulrike Holzgrabe is an academic researcher from University of Würzburg. The author has contributed to research in topics: Allosteric regulation & Capillary electrophoresis. The author has an hindex of 45, co-authored 566 publications receiving 9806 citations. Previous affiliations of Ulrike Holzgrabe include Jagiellonian University & University of Illinois at Chicago.
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Routine quality control of medicines in developing countries: Analytical challenges, regulatory infrastructures and the prevalence of counterfeit medicines in Tanzania
Ludwig Höllein,Eliangiringa Kaale,Eliangiringa Kaale,Yonah H. Mwalwisi,Marco H. Schulze,Ulrike Holzgrabe +5 more
TL;DR: In this paper, the authors collected information on the prevalence of counterfeit and substandard pharmaceuticals in Tanzania and discussed suitable analytical approaches for their analysis, e.g. non-sophisticated HPLC, low-field NMR, capillary electrophoresis, or vibrational spectroscopy.
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Atypical Muscarinic Allosteric Modulation: Cooperativity between Modulators and Their Atypical Binding Topology in Muscarinic M2 and M2/M5 Chimeric Receptors
Christian Tränkle,Andreas Dittmann,Uwe Schulz,Oliver Weyand,Stefan Buller,Kirstin Jöhren,Eberhard Heller,Nigel Birdsall,Ulrike Holzgrabe,John Ellis,Hans Dieter Höltje,Klaus Mohr +11 more
TL;DR: The atypical actions of tacrine and Duo3 involve different modes of receptor interaction, but their sites of attachment seem to be the “common” allosteric binding domain at the entrance to the orthosteric ligand binding pocket of the M2-receptor.
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A Photoswitchable Dualsteric Ligand Controlling Receptor Efficacy
Luca Agnetta,Michael Kauk,Maria Consuelo Alonso Canizal,Regina Messerer,Ulrike Holzgrabe,Carsten Hoffmann,Carsten Hoffmann,Michael Decker +7 more
TL;DR: BQCAAI proved to be an unprecedented molecular tool; it is the first photoswitchable dualsteric ligand, and its activity can be regulated by light, and it was applied to investigate the time course of several receptor activation processes.
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Composition of OSCS-contaminated heparin occurring in 2008 in batches on the German market.
Tanja Beyer,Magnus Matz,Daniela Brinz,Oliver Rädler,Bernhard Wolf,Jochen Norwig,Knout Baumann,Susanne Alban,Ulrike Holzgrabe +8 more
TL;DR: Analysis of a representative set of heparin samples proves the suitability of 1H NMR spectroscopy for the quality control ofheparin of both glycosaminoglycans and residual solvents.
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Search for dual function inhibitors for Alzheimer’s disease: Synthesis and biological activity of acetylcholinesterase inhibitors of pyridinium-type and their Aβ fibril formation inhibition capacity
TL;DR: The anti-Abeta fibril formation property of AChE inhibitors of pyridinium- and bispyrid inium-type was evaluated to expand their activity profile and to reveal potential additive pharmacological effects which may reinforce their therapeutic application besides their capacity of increasing acetylcholine levels.