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Umar Mahmood
Researcher at Harvard University
Publications - 221
Citations - 19114
Umar Mahmood is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & In vivo. The author has an hindex of 54, co-authored 207 publications receiving 17286 citations. Previous affiliations of Umar Mahmood include Fox Chase Cancer Center & Cornell University.
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Journal ArticleDOI
Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival.
Berna C. Özdemir,Berna C. Özdemir,Tsvetelina Pentcheva-Hoang,Julienne L. Carstens,Xiaofeng Zheng,Chia Chin Wu,Tyler R. Simpson,Hanane Laklai,Hikaru Sugimoto,Hikaru Sugimoto,Christoph Kahlert,Christoph Kahlert,Sergey V. Novitskiy,Ana De Jesus-Acosta,Padmanee Sharma,Pedram Heidari,Umar Mahmood,Lynda Chin,Harold L. Moses,Valerie M. Weaver,Anirban Maitra,James P. Allison,Valerie S. LeBleu,Valerie S. LeBleu,Raghu Kalluri,Raghu Kalluri +25 more
TL;DR: Although myofibroblast-depleted tumors did not respond to gemcitabine, anti-CTLA4 immunotherapy reversed disease acceleration and prolonged animal survival, and underscores the need for caution in targeting carcinoma-associated fibroblasts in PDAC.
Journal ArticleDOI
In vivo imaging of tumors with protease-activated near-infrared fluorescent probes.
TL;DR: In vivo imaging showed a 12-fold increase in NIRF signal, allowing the detection of tumors with submillimeter-sized diameters, and this strategy can be used to detect such early stage tumors in vivo and to probe for specific enzyme activity.
Journal ArticleDOI
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
Jeffrey A. Engelman,Jeffrey A. Engelman,Liang Chen,Xiaohong Tan,Katherine Crosby,Alexander R. Guimaraes,Rabi Upadhyay,S. Michel Maira,Kate McNamara,Samanthi A. Perera,Youngchul Song,Lucian R. Chirieac,Ramneet Kaur,Angela Lightbown,Jessica Simendinger,Timothy Q. Li,Robert F. Padera,Carlos Garcia-Echeverria,Ralph Weissleder,Umar Mahmood,Lewis C. Cantley,Lewis C. Cantley,Kwok-Kin Wong +22 more
TL;DR: In vivo studies suggest that inhibitors of the PI3K-mTOR pathway may be active in cancers with PIK3CA mutations and, when combined with MEK inhibitors, may effectively treat KRAS mutated lung cancers.
Journal ArticleDOI
In vivo magnetic resonance imaging of transgene expression.
Ralph Weissleder,Anna Moore,Umar Mahmood,Rajeev Bhorade,Helene Benveniste,E. Antonio Chiocca,James P. Basilion +6 more
Journal ArticleDOI
Arthritis Critically Dependent on Innate Immune System Players
Hong Ji,Koichiro Ohmura,Koichiro Ohmura,Umar Mahmood,David M. Lee,Frans M. A. Hofhuis,Susan A. Boackle,Kazue Takahashi,V. Michael Holers,Mark Walport,Craig Gerard,Alan Ezekowitz,Michael C. Carroll,Michael B. Brenner,Ralph Weissleder,J. Sjef Verbeek,Veronique Duchatelle,Claude Degott,Christophe Benoist,Christophe Benoist,Christophe Benoist,Diane Mathis,Diane Mathis,Diane Mathis +23 more
TL;DR: It is suggested that autoimmune disease, even one that is organ specific, can occur when mobilization of an adaptive immune response results in runaway activation of the innate response.