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Esperanza Perucha
Researcher at King's College London
Publications - 32
Citations - 2265
Esperanza Perucha is an academic researcher from King's College London. The author has contributed to research in topics: T cell & Medicine. The author has an hindex of 18, co-authored 28 publications receiving 1906 citations. Previous affiliations of Esperanza Perucha include University of Alcalá & Guy's and St Thomas' NHS Foundation Trust.
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Journal ArticleDOI
Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans
Pervinder Sagoo,Esperanza Perucha,Birgit Sawitzki,Stefan Tomiuk,David A. Stephens,Patrick Miqueu,S Chapman,Ligia Craciun,Ruhena Sergeant,Sophie Brouard,Flavia Rovis,Elvira Jimenez,Amany Ballow,Magali Giral,Irene Rebollo-Mesa,Alain Le Moine,Cécile Braudeau,Rachel Hilton,Bernhard Gerstmayer,Katarzyna Bourcier,Adnan Sharif,Magdalena Krajewska,Graham M. Lord,Ian S.D. Roberts,Michel Goldman,Kathryn J. Wood,Kenneth A. Newell,Vicki Seyfert-Margolis,Anthony N. Warrens,Uwe Janssen,Hans-Dieter Volk,Jean-Paul Soulillou,Maria P. Hernandez-Fuentes,Robert I. Lechler +33 more
TL;DR: An immunological profile of the tolerant state is provided that, with further validation, should inform and shape drug-weaning protocols in renal transplant recipients.
Journal ArticleDOI
T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements
Aditi Kanhere,Arnulf Hertweck,Urvashi Bhatia,M. Refik Gökmen,Esperanza Perucha,Ian Jackson,Graham M. Lord,Richard G. Jenner +7 more
TL;DR: T-bet and GATA3 regulate the CD4+ T cell Th1/Th2 cell fate decision but little is known about the interplay between these factors outside of the murine Ifng and Il4/Il5/Il13 loci.
Journal ArticleDOI
Meta-analysis identifies multiple loci associated with kidney function–related traits in east Asian populations
Yukinori Okada,Xueling Sim,Xueling Sim,Min Jin Go,Jer-Yuarn Wu,Jer-Yuarn Wu,Dongfeng Gu,Fumihiko Takeuchi,Atsushi Takahashi,Shiro Maeda,Tatsuhiko Tsunoda,Peng Chen,Su Chi Lim,Su Chi Lim,Tien Yin Wong,Tien Yin Wong,Tien Yin Wong,Jianjun Liu,Terri L. Young,Tin Aung,Tin Aung,Mark Seielstad,Yik Ying Teo,Yik Ying Teo,Young-Jin Kim,Jong-Young Lee,Bok Ghee Han,Daehee Kang,Chien Hsiun Chen,Chien Hsiun Chen,Fuu Jen Tsai,Li-Ching Chang,S. J. Fann,Hao Mei,Dabeeru C. Rao,James E. Hixson,Shufeng Chen,Tomohiro Katsuya,Motohide Isono,Toshio Ogihara,Toshio Ogihara,John C. Chambers,Weihua Zhang,Jaspal S. Kooner,E Albrecht,Kazuhiko Yamamoto,Michiaki Kubo,Yusuke Nakamura,Kamatani Naoyuki,Norihiro Kato,Jiang He,Yuan-Tsong Chen,Yoon Shin Cho,E-Shyong Tai,Toshihiro Tanaka,Graham M. Lord,P. van der Harst,Debbie A Lawlor,Jobanpreet Sehmi,Daniel P. Gale,Mark N. Wass,Kourosh R. Ahmadi,Stephan J. L. Bakker,Jacqui Beckmann,Hjg Bilo,Murielle Bochud,Morris J. Brown,M. J. Caulfield,Jmc Connell,H.T. Cook,Ioana Cotlarciuc,George Davey Smith,R. de Silva,G. Deng,Olivier Devuyst,L. D. Dikkeschei,N. Dimkovic,M. Dockrell,Anna F. Dominiczak,S Ebrahim,Thomas Eggermann,Martin Farrall,L Ferrucci,Juergen Floege,Nita G. Forouhi,Ron T. Gansevoort,X. Han,Bo Hedblad,J. J. van der Heide,Bouke G. Hepkema,Maria P. Hernandez-Fuentes,Elina Hyppönen,Toby Johnson,P. E. De Jong,Nanno Kleefstra,Vasiliki Lagou,Marta Lapsley,Yun Li,Ruth J. F. Loos,Jian'an Luan,Karin Luttropp,Céline Maréchal,Olle Melander,Patricia B. Munroe,Louise Nordfors,Afshin Parsa,Leena Peltonen,B.W.J.H. Penninx,Esperanza Perucha,A Pouta,Inga Prokopenko,Paul Roderick,Aimo Ruokonen,Nilesh J. Samani,Serena Sanna,Martin Schalling,David Schlessinger,Georg Schlieper,Marc A. Seelen,A. R. Shuldiner,Marketa Sjögren,J.H. Smit,Harold Snieder,Nicola Soranzo,Tim D. Spector,Peter Stenvinkel,Michael J.E. Sternberg,R. Swaminathan,L.J. Ubink-Veltmaat,Manuela Uda,Peter Vollenweider,Chris Wallace,Dawn M. Waterworth,Klaus Zerres,Gérard Waeber,Nicholas J. Wareham,Patrick H. Maxwell,Mark I. McCarthy,M-R Jarvelin,Vincent Mooser,G. Abecasis,Liz Lightstone,Jemima Scott,Gerjan Navis,Paul Elliott,Anna Köttgen,C. Pattaro,Carsten A. Böger,Christian Fuchsberger,Matthias Olden,Nicole L. Glazer,X. Gao,Qiong Yang,Albert V. Smith,Jeffery R. O'Connell,Man Li,H. Schmidt,A Isaacs,Shamika Ketkar,Shih-Jen Hwang,Andrew D. Johnson,Abbas Dehghan,A. Teumer,Guillaume Paré,Elizabeth J. Atkinson,Tanja Zeller,Kurt Lohman,Marilyn C. Cornelis,Nicole Probst-Hensch,Florian Kronenberg,A Tönjes,Caroline Hayward,Thor Aspelund,G. Eiriksdottir,L. J. Launer,T.B. Harris,Evandine Rampersaud,B. D. Mitchell,D.E. Arking,Eric Boerwinkle,Maksim Struchalin,Margherita Cavalieri,AB Singleton,Francesco Giallauria,Jeffrey Metter,I. H. de Boer,Talin Haritunians,Thomas Lumley,David S. Siscovick,Bruce M. Psaty,M. C. Zillikens,B.A. Oostra,Mary F. Feitosa,M. A. Province,M. De Andrade,Stephen T. Turner,Arne Schillert,Anette-G. Ziegler,Philipp S. Wild,Renate B. Schnabel,Sandra Wilde,Thomas Münzel,Tennille S. Leak,Thomas Illig,N. Klopp,Christine Meisinger,Heinz Erich Wichmann,Wolfgang Koenig,Lina Zgaga,Tatijana Zemunik,Ivana Kolcic,Cosetta Minelli,Frank B. Hu,Johansson,Wilmar Igl,Ghazal Zaboli,Sarah H. Wild,A. F. Wright,Hannah Campbell,David Ellinghaus,Stuart L. Schreiber,Y S Aulchenko,Janine F. Felix,F. Rivadeneira,A.G. Uitterlinden,A. Hofman,Medea Imboden,Dorothea Nitsch,Anita Brandstätter,Barbara Kollerits,Lyudmyla Kedenko,Reedik Mägi,Michael Stumvoll,Peter Kovacs,Mladen Boban,Sharon Campbell,Karlhans Endlich,Henry Völzke,Heyo K. Kroemer,Matthias Nauck,Uwe Völker,Ozren Polašek,Veronique Vitart,Sunita Badola,Alex Parker,Paul M. Ridker,Sharon L.R. Kardia,Stefan Blankenberg,Yongmei Liu,G. C. Curhan,Andre Franke,Tatiana Rochat,B. Paulweber,W. Wang,Vilmundur Gudnason,Josef Coresh,Reinhold E. Schmidt,Michael G. Shlipak,C M van Duijn,Ingrid B. Borecki,Bernhard K. Krämer,Igor Rudan,Ulf Gyllensten,J.F. Wilson,J. C. M. Witteman,Peter P. Pramstaller,Rainer Rettig,Nicholas D. Hastie,Daniel I. Chasman,W. H. Kao,I. M. Heid,Caroline S. Fox,Jan Krumsiek,Claudia Hundertmark,Giorgio Pistis,Daniela Ruggiero,M. O'seaghdha,T. Haller,Z. Kutalik,Julia Shi,P. S. Middelberg,Angelo L. Gaffo,Nicola Pirastu,Guo Li,Jennifer E. Huffman,Loic Yengo,Jing Hua Zhao,Ayse Demirkan,M. F. Feitosa,Xuan Liu,Giovanni Malerba,Lorna M. Lopez,Xinzhong Li,Marcus E. Kleber,Andrew A. Hicks,Ilja M. Nolte,Åsa Johansson,Federico Murgia,J F Peden,Maristella Steri,Albert Tenesa,Perttu Salo,Massimo Mangino,Lynda M. Rose,Terho Lehtimäki,Owen M. Woodward,Adrienne Tin,Craig Muller,Christopher Oldmeadow,Margus Putku,Darina Czamara,Peter Kraft,Laura Frogheri,Gian Andri Thun,Anne Grotevendt,Gauti Kjartan Gislason,Patrick F. McArdle,Michael Schallert,N. G. Martin,Grant W. Montgomery,David R. Jacobs,Kiang Liu,Pio D'Adamo,S. Ulivi,Jerome I. Rotter,P. Navaro,B. Balkau,Philippe Froguel,Tõnu Esko,Andres Salumets,Kay-Tee Khaw,Claudia Langenberg,Aldi T. Kraja,Qunyuan Zhang,Rodney J. Scott,Elizabeth G. Holliday,Elin Org,Margus Viigimaa,Stefania Bandinelli,Jeffery Metter,Antonio Lupo,Elisabetta Trabetti,Rossella Sorice,Angela Döring,Eva Lattka,Konstantin Strauch,Fabian J. Theis,M. Waldenberger,G. Davies,Alan J. Gow,Marcel Bruinenberg,Ronald P. Stolk,Winkelmann Br,B O Boehm,Susanne Lucae,G. Curhan,Poorva Mudgal,Robert M. Plenge,Laura Portas,Ivana Persico,Mirna Kirin,I. Mateo Leach,W. H. Van Gilst,Anuj Goel,Halit Ongen,A. von Eckardstein,Francesco Cucca,Ramaiah Nagaraja,Maria Grazia Piras,Claudia Schurmann,Klemens Budde,Florian Ernst,Susan M. Farrington,Evropi Theodoratou,A. Jula,M. Perola,V. Salomaa,So-Youn Shin,Cinzia Sala,Mika Kähönen,Jorma Viikari,Christian Hengstenberg,Christopher P. Nelson,James F. Meschia,Michael A. Nalls,Pankaj Sharma,Andrew B. Singleton,Michel Burnier,John Attia,Maris Laan,Hans L. Hillege,Stefan Kloiber,Hyon K. Choi,Mario Pirastu,Silvia Tore,John Whitfield,Myriam Fornage,Paolo Gasparini,David S. Siscovick,Nabila Bouatia-Naji,Andres Metspalu,Ingrid B. Borecki,Giovanni Gambaro,Ian J. Deary,Bruce H. R. Wolffenbuttel,W. März,Hugh Watkins,Sabine Schipf,Malcolm G. Dunlop,S. Ripatti,Daniela Toniolo,Olli T. Raitakari,Marina Ciullo,Mark J. Caulfield,C Gieger +414 more
TL;DR: A meta-analysis of genome-wide association studies for kidney function–related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN), identified 17 loci newly associated with kidney function-related traits.
Journal ArticleDOI
Genetic loci influencing kidney function and chronic kidney disease
John C. Chambers,Weihua Zhang,Graham M. Lord,Graham M. Lord,Pim van der Harst,Debbie A Lawlor,Joban Sehmi,Daniel P. Gale,Mark N. Wass,Kourosh R. Ahmadi,Stephan J. L. Bakker,Jacqui Beckmann,Henk J. G. Bilo,Murielle Bochud,Morris J. Brown,Mark J. Caulfield,John M. C. Connell,H. Terence Cook,Ioana Cotlarciuc,George Davey Smith,Ranil de Silva,Guohong Deng,Olivier Devuyst,Lambert D Dikkeschei,Nada Dimkovic,Mark Dockrell,Anna F. Dominiczak,Shah Ebrahim,Thomas Eggermann,Martin Farrall,Luigi Ferrucci,Jürgen Floege,Nita G. Forouhi,Ron T. Gansevoort,Xijin Han,Bo Hedblad,Jaap J. Homan van der Heide,Bouke G. Hepkema,Maria P. Hernandez-Fuentes,Maria P. Hernandez-Fuentes,Elina Hyppönen,Toby Johnson,Paul E. de Jong,Nanne Kleefstra,Vasiliki Lagou,Marta Lapsley,Yun Li,Ruth J. F. Loos,Jian'an Luan,Karin Luttropp,Céline Maréchal,Olle Melander,Patricia B. Munroe,Louise Nordfors,Afshin Parsa,Leena Peltonen,Leena Peltonen,Leena Peltonen,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Esperanza Perucha,Esperanza Perucha,Anneli Pouta,Inga Prokopenko,Paul Roderick,Aimo Ruokonen,Nilesh J. Samani,Serena Sanna,Martin Schalling,David Schlessinger,Georg Schlieper,Marc A. Seelen,Alan R. Shuldiner,Marketa Sjögren,Johannes H. Smit,Johannes H. Smit,Johannes H. Smit,Harold Snieder,Nicole Soranzo,Tim D. Spector,Peter Stenvinkel,Michael J.E. Sternberg,R. Swaminathan,Toshiko Tanaka,L.J. Ubink-Veltmaat,Manuela Uda,Peter Vollenweider,Chris Wallace,Dawn M. Waterworth,Klaus Zerres,Gérard Waeber,Nicholas J. Wareham,Patrick H. Maxwell,Mark I. McCarthy,Marjo-Riitta Järvelin,Vincent Mooser,Gonçalo R. Abecasis,Liz Lightstone,James Scott,Gerjan Navis,Paul Elliott,Jaspal S. Kooner +102 more
TL;DR: Using genome-wide association, common variants at 2p12–p13, 6q26, 17q23 and 19q13 associated with serum creatinine associated with chronic kidney disease are identified.
Journal ArticleDOI
C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation
Elham Asgari,Gaelle Le Friec,Hidekazu Yamamoto,Esperanza Perucha,Steven S. Sacks,Jörg Köhl,Jörg Köhl,H. Terence Cook,Claudia Kemper +8 more
TL;DR: Mechanistically, C3a drives IL-1β production in monocytes by controlling the release of intracellular ATP into the extracellular space via regulation of as-yet unidentified ATP-releasing channels in an extacellular signal-regulated kinase 1/2-dependent fashion, which defines a novel function for complement in inflammasome activation in monocyte activation.