V
Virginie Mansuy-Aubert
Researcher at Loyola University Chicago
Publications - 22
Citations - 424
Virginie Mansuy-Aubert is an academic researcher from Loyola University Chicago. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 5, co-authored 14 publications receiving 280 citations. Previous affiliations of Virginie Mansuy-Aubert include University of Texas Southwestern Medical Center & Sanford-Burnham Institute for Medical Research.
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Journal ArticleDOI
Imbalance between neutrophil elastase and its inhibitor α1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure.
Virginie Mansuy-Aubert,Qiong L. Zhou,Xiangyang Xie,Zhenwei Gong,Jun Yuan Huang,Abdul Rehman Khan,Abdul Rehman Khan,Gregory Aubert,Karla Candelaria,Shantele Thomas,Dong Ju Shin,Sarah Booth,Shahid Mahmood Baig,Ahmed Bilal,Daehee Hwang,Hui Zhang,Hui Zhang,Robin Lovell-Badge,Steven R. Smith,Steven R. Smith,Fazli Rabbi Awan,Zhen Y. Jiang +21 more
TL;DR: Obese mice and human subjects have increased activity of neutrophil elastase (NE) and decreased serum levels of the NE inhibitor α1-antitrypsin (A1AT, SerpinA1) and data suggest that the A1AT-NE system regulates AMPK signaling, FAO, and energy expenditure.
Journal ArticleDOI
C2 Domain-Containing Phosphoprotein CDP138 Regulates GLUT4 Insertion into the Plasma Membrane
Xiangyang Xie,Zhenwei Gong,Virginie Mansuy-Aubert,Qiong L. Zhou,Suren A. Tatulian,Daniel Sehrt,Florian Gnad,Laurence M. Brill,Khatereh Motamedchaboki,Yu Chen,Michael P. Czech,Matthias Mann,Marcus Krüger,Zhen Y. Jiang +13 more
TL;DR: Results suggest that CDP138 is a key molecule linking the Akt2 pathway to the regulation of GLUT4 vesicle-PM fusion, and a previously uncharacterized 138 kDa C2 domain-containing phosphoprotein is a substrate forAkt2.
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Fecal transplantation and butyrate improve neuropathic pain, modify immune cell profile, and gene expression in the PNS of obese mice
Raiza Bonomo,Tyler Cook,Chaitanya K. Gavini,Chelsea R. White,Jacob R. Jones,Elisa Bovo,Aleksey V. Zima,Isabelle A. Brown,Lara R. Dugas,Eleonora Zakharian,Gregory Aubert,Francis Alonzo,Nigel A. Calcutt,Virginie Mansuy-Aubert +13 more
TL;DR: The data suggest that fecal transplantation from lean to obese, insulin-resistant mice decreases obesity-induced hypersensitivity and increases nerve density in the skin, and circulating butyrate, a metabolite secreted by gut microbiome and absorbed in the blood stream, underlies some of the effects of FMT.
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Liver X Receptors Protect Dorsal Root Ganglia from Obesity-Induced Endoplasmic Reticulum Stress and Mechanical Allodynia.
Chaitanya K. Gavini,Angie L. Bookout,Raiza Bonomo,Laurent Gautron,Syann Lee,Virginie Mansuy-Aubert +5 more
TL;DR: It is demonstrated that neuronal liver X receptor (LXR) activation delays ER stress and allodynia in WD-fed mice and suggests that lipid-binding nuclear receptors expressed in the sensory neurons of the DRG play a role in the onset of obesity-induced hypersensitivity.
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Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure
Virginie Mansuy-Aubert,Laurent Gautron,Syann Lee,Angie L. Bookout,Christine M. Kusminski,Kai Sun,Yuan Zhang,Philipp E. Scherer,David J. Mangelsdorf,Joel K. Elmquist +9 more
TL;DR: This study shows mice lacking LXRα/β in peripheral sensory neurons have increased energy expenditure and weight loss when fed a Western diet (WD), and suggests the ability to metabolize and sense cholesterol and/or fatty acids in peripheral neurons is an important requirement for physiological adaptations to WDs.