V
Vladimir Jojic
Researcher at University of North Carolina at Chapel Hill
Publications - 74
Citations - 5599
Vladimir Jojic is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Population & Immune system. The author has an hindex of 25, co-authored 70 publications receiving 4426 citations. Previous affiliations of Vladimir Jojic include Stanford University & University of Toronto.
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Journal ArticleDOI
Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences
Petter Brodin,Petter Brodin,Vladimir Jojic,Tianxiang Gao,Sanchita Bhattacharya,Cesar J. Lopez Angel,David Furman,Shai S. Shen-Orr,Cornelia L. Dekker,Gary E. Swan,Atul J. Butte,Atul J. Butte,Holden T. Maecker,Mark M. Davis +13 more
TL;DR: A systems-level analysis of 210 healthy twins between 8 and 82 years of age found that 77% of parameters, including cell population frequencies, cytokine responses, and serum proteins, are dominated by non-heritable influences, and in MZ twins discordant for cytomegalovirus infection, more than half of all parameters are affected.
Journal ArticleDOI
Deciphering the transcriptional network of the dendritic cell lineage
Jennifer Miller,Brian D. Brown,Tal Shay,Emmanuel L. Gautier,Emmanuel L. Gautier,Vladimir Jojic,Vladimir Jojic,Ariella Cohain,Gaurav Pandey,Marylene Leboeuf,Kutlu G. Elpek,Julie Helft,Daigo Hashimoto,Andrew Chow,Andrew Chow,Jeremy Price,Melanie Greter,Melanie Greter,Milena Bogunovic,Angelique Bellemare-Pelletier,Paul S. Frenette,Gwendalyn J. Randolph,Gwendalyn J. Randolph,Shannon J. Turley,Miriam Merad +24 more
TL;DR: A transcriptional program expressed specifically during the steady-state migration of tissue DCs to the draining lymph nodes that may control tolerance to self tissue antigens is identified and predicted regulators of DC functional diversity in tissues are predicted.
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Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination
David Furman,Boris P. Hejblum,Noah Simon,Vladimir Jojic,Cornelia L. Dekker,Rodolphe Thiébaut,Robert Tibshirani,Mark M. Davis +7 more
TL;DR: A system analysis of the neutralizing antibody response to a trivalent inactivated seasonal influenza vaccine and a large number of immune system components finds a strong association between androgens and genes involved in lipid metabolism, suggesting that these could be important drivers of the differences in immune responses between males and females.
Journal ArticleDOI
Conservation and divergence in the transcriptional programs of the human and mouse immune systems
Tal Shay,Vladimir Jojic,Or Zuk,Katherine Rothamel,David Puyraimond-Zemmour,Ting Feng,Ei Wakamatsu,Christophe Benoist,Daphne Koller,Aviv Regev +9 more
TL;DR: Two large compendia of transcriptional profiles of human and mouse immune cell types are compared, finding that global transcription profiles are conserved between corresponding cell lineages but to a lower degree, suggesting that distinct regulation may underlie some of the conserved transcriptional responses.
Journal ArticleDOI
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states
David Furman,David Furman,Junlei Chang,Lydia Lartigue,Christopher R. Bolen,Francois Haddad,Brice Gaudilliere,Edward A. Ganio,Gabriela K. Fragiadakis,Matthew H. Spitzer,Isabelle Douchet,Sophie Daburon,Jean-François Moreau,Garry P. Nolan,Patrick Blanco,Julie Déchanet-Merville,Cornelia L. Dekker,Vladimir Jojic,Calvin J. Kuo,Mark M. Davis,Benjamin Faustin +20 more
TL;DR: It is found that the expression of specific inflammasome gene modules stratifies older individuals into two extremes: those with constitutive expression of IL-1β, nucleotide metabolism dysfunction, elevated oxidative stress, high rates of hypertension and arterial stiffness; and those without constitutive expresses IL- 1β, who lack these characteristics.