Vladimir Jojic

TL;DR: A systems-level analysis of 210 healthy twins between 8 and 82 years of age found that 77% of parameters, including cell population frequencies, cytokine responses, and serum proteins, are dominated by non-heritable influences, and in MZ twins discordant for cytomegalovirus infection, more than half of all parameters are affected.

TL;DR: A transcriptional program expressed specifically during the steady-state migration of tissue DCs to the draining lymph nodes that may control tolerance to self tissue antigens is identified and predicted regulators of DC functional diversity in tissues are predicted.

TL;DR: A system analysis of the neutralizing antibody response to a trivalent inactivated seasonal influenza vaccine and a large number of immune system components finds a strong association between androgens and genes involved in lipid metabolism, suggesting that these could be important drivers of the differences in immune responses between males and females.

TL;DR: Two large compendia of transcriptional profiles of human and mouse immune cell types are compared, finding that global transcription profiles are conserved between corresponding cell lineages but to a lower degree, suggesting that distinct regulation may underlie some of the conserved transcriptional responses.

TL;DR: It is found that the expression of specific inflammasome gene modules stratifies older individuals into two extremes: those with constitutive expression of IL-1β, nucleotide metabolism dysfunction, elevated oxidative stress, high rates of hypertension and arterial stiffness; and those without constitutive expresses IL- 1β, who lack these characteristics.