W
Weng Hua Khoo
Researcher at Garvan Institute of Medical Research
Publications - 15
Citations - 716
Weng Hua Khoo is an academic researcher from Garvan Institute of Medical Research. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 6, co-authored 7 publications receiving 380 citations. Previous affiliations of Weng Hua Khoo include University of New South Wales.
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Journal ArticleDOI
Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche.
Michelle A. Lawson,Michelle M. McDonald,Michelle M. McDonald,Nataša Kovačić,Weng Hua Khoo,Weng Hua Khoo,Rachael L. Terry,Rachael L. Terry,Jenny Down,Warren Kaplan,Warren Kaplan,Julia Paton-Hough,Clair Fellows,Jessica A. Pettitt,T. Neil Dear,Els Van Valckenborgh,Paul A. Baldock,Paul A. Baldock,Michael J. Rogers,Michael J. Rogers,Colby L. Eaton,Karin Vanderkerken,Allison R. Pettit,Julian M.W. Quinn,Andrew C.W. Zannettino,Tri Giang Phan,Tri Giang Phan,Peter I. Croucher,Peter I. Croucher +28 more
TL;DR: It is demonstrated that dormancy is a reversible state that is switched 'on' by engagement with bone-lining cells or osteoblasts, and switched ‘off' by osteoclasts remodelling the endosteal niche.
Journal ArticleDOI
Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption
Michelle M. McDonald,Michelle M. McDonald,Weng Hua Khoo,Weng Hua Khoo,Pei Ying Ng,Ya Xiao,Jad Zamerli,Peter Thatcher,Wunna Kyaw,Karrnan Pathmanandavel,Abigail K. Grootveld,Imogen Moran,Danyal Butt,Akira Nguyen,Alexander P. Corr,Alexander P. Corr,Sean C. Warren,Maté Biro,Natalie C. Butterfield,Siobhan E. Guilfoyle,Davide Komla-Ebri,Michael R.G. Dack,Hannah F. Dewhurst,John G. Logan,Yongxiao Li,Sindhu T. Mohanty,Sindhu T. Mohanty,Niall M. Byrne,Niall M. Byrne,Rachael L. Terry,Rachael L. Terry,Marija K. Simic,Marija K. Simic,Ryan C. Chai,Julian M.W. Quinn,Julian M.W. Quinn,Scott E. Youlten,Jessica A. Pettitt,David Abi-Hanna,David Abi-Hanna,Rohit Jain,Rohit Jain,Wolfgang Weninger,Wolfgang Weninger,Wolfgang Weninger,Mischa Lundberg,Mischa Lundberg,Shuting Sun,F H Ebetino,Paul Timpson,Woei Ming Lee,Paul A. Baldock,Paul A. Baldock,Michael J. Rogers,Michael J. Rogers,Robert Brink,Robert Brink,Graham R. Williams,J. H. Duncan Bassett,John P. Kemp,John P. Kemp,Nathan J. Pavlos,Peter I. Croucher,Peter I. Croucher,Tri Giang Phan,Tri Giang Phan +65 more
TL;DR: This article showed that osteomorphs are transcriptionally distinct from osteoclasts and macrophages and express a number of non-canonical osteoclast genes that are associated with structural and functional bone phenotypes when deleted in mice.
Journal ArticleDOI
A niche-dependent myeloid transcriptome signature defines dormant myeloma cells
Weng Hua Khoo,Weng Hua Khoo,Guy Ledergor,Guy Ledergor,Assaf Weiner,Daniel L. Roden,Rachael L. Terry,Michelle M. McDonald,Michelle M. McDonald,Ryan C. Chai,Kim De Veirman,Katie L. Owen,Khatora S. Opperman,Kate Vandyke,Justine R. Clark,Anja Seckinger,Nataša Kovačić,Akira Nguyen,Akira Nguyen,Sindhu T. Mohanty,Jessica A. Pettitt,Ya Xiao,Alexander P. Corr,Alexander P. Corr,Christine Seeliger,Mark Novotny,Roger S. Lasken,Tuan V. Nguyen,Tuan V. Nguyen,Tuan V. Nguyen,Babatunde O. Oyajobi,Dana T. Aftab,Alexander Swarbrick,Alexander Swarbrick,Belinda S. Parker,Duncan R. Hewett,Dirk Hose,Karin Vanderkerken,Andrew C.W. Zannettino,Ido Amit,Tri Giang Phan,Tri Giang Phan,Peter I. Croucher,Peter I. Croucher +43 more
TL;DR: Engagement ofMyeloma cells with the osteoblastic niche induces expression of a suite of myeloid genes that predicts disease progression and that are potential drug targets to eradicate dormant myel cancer cells.
Journal ArticleDOI
Memory B cells are reactivated in subcapsular proliferative foci of lymph nodes.
Imogen Moran,Imogen Moran,Akira Nguyen,Akira Nguyen,Weng Hua Khoo,Weng Hua Khoo,Danyal Butt,Katherine Bourne,Clara Young,Jana R. Hermes,Maté Biro,Gary Gracie,Cindy S. Ma,Cindy S. Ma,C Mee Ling Munier,Fabio Luciani,Fabio Luciani,John Zaunders,John Zaunders,Andrew Parker,Anthony D. Kelleher,Anthony D. Kelleher,Stuart G. Tangye,Stuart G. Tangye,Peter I. Croucher,Peter I. Croucher,Robert Brink,Robert Brink,Mark Read,Tri Giang Phan,Tri Giang Phan +30 more
TL;DR: It is shown that memory B cells localise to lymph node subcapsular proliferative foci (SPF), which have distinct properties from the germinal centre, for rapid expansion and the induction of B memory responses.
Journal ArticleDOI
Prostate cancer cell-intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone
Katie L. Owen,Katie L. Owen,Linden J. Gearing,Linden J. Gearing,Damien Zanker,Damien Zanker,Natasha K Brockwell,Natasha K Brockwell,Weng Hua Khoo,Weng Hua Khoo,Daniel L. Roden,Daniel L. Roden,Marek Cmero,Stefano Mangiola,Matthew K.H. Hong,Alex Spurling,Michelle M. McDonald,Chia Ling Chan,Anupama Pasam,Ruth J. Lyons,Hendrika M. Duivenvoorden,Andrew Ryan,Lisa M. Butler,John M. Mariadason,Tri Giang Phan,Tri Giang Phan,Vanessa M. Hayes,Vanessa M. Hayes,Shahneen Sandhu,Alexander Swarbrick,Alexander Swarbrick,Niall M. Corcoran,Niall M. Corcoran,Niall M. Corcoran,Paul J. Hertzog,Paul J. Hertzog,Peter I. Croucher,Peter I. Croucher,Christopher M. Hovens,Belinda S. Parker,Belinda S. Parker,Belinda S. Parker +41 more
TL;DR: It is demonstrated that loss of tumor‐intrinsic type I IFN occurs in proliferating prostate cancer cells in bone, which suppresses tumor immunogenicity and therapeutic response and promotes bone cell activation to drive cancer progression.