E
Els Van Valckenborgh
Researcher at Vrije Universiteit Brussel
Publications - 65
Citations - 3264
Els Van Valckenborgh is an academic researcher from Vrije Universiteit Brussel. The author has contributed to research in topics: Bone marrow & Multiple myeloma. The author has an hindex of 30, co-authored 65 publications receiving 2813 citations. Previous affiliations of Els Van Valckenborgh include Université libre de Bruxelles.
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Journal ArticleDOI
Report of the European Myeloma Network on multiparametric flow cytometry in multiple myeloma and related disorders
Andy C. Rawstron,Alberto Orfao,Meral Beksac,Ludmila Bezdickova,Rik A. Brooimans,Horia Bumbea,Klara Dalva,Gwenny M. Fuhler,Jan W. Gratama,Dirk Hose,Lucie Kovarova,Michael Lioznov,Gema Mateo,Ricardo Morilla,Anne K. Mylin,Paola Omedè,Catherine Pellat-Deceunynck,Martin Perez Andres,Maria Teresa Petrucci,Marina Ruggeri,Grzegorz Rymkiewicz,Alexander Schmitz,Martin Schreder,Carine Seynaeve,Martin Spacek,Ruth M. de Tute,Els Van Valckenborgh,Nicola J. Weston-Bell,Roger G. Owen,Jesús F. San Miguel,Pieter Sonneveld,Hans Erik Johnsen +31 more
TL;DR: The primary clinical applications identified were: differential diagnosis of neoplastic plasma cell disorders from reactive plasmacytosis; identifying risk of progression in patients with MGUS and detecting minimal residual disease.
Journal ArticleDOI
Bone marrow stromal cell-derived exosomes as communicators in drug resistance in multiple myeloma cells.
Jinheng Wang,Jinheng Wang,An Hendrix,Sophie Hernot,Miguel Lemaire,Elke De Bruyne,Els Van Valckenborgh,Tony Lahoutte,Olivier De Wever,Karin Vanderkerken,Eline Menu +10 more
TL;DR: The results demonstrate the involvement of exosome-mediated communication in BMSC-induced proliferation, migration, survival, and drug resistance of MM cells.
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Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche.
Michelle A. Lawson,Michelle M. McDonald,Michelle M. McDonald,Nataša Kovačić,Weng Hua Khoo,Weng Hua Khoo,Rachael L. Terry,Rachael L. Terry,Jenny Down,Warren Kaplan,Warren Kaplan,Julia Paton-Hough,Clair Fellows,Jessica A. Pettitt,T. Neil Dear,Els Van Valckenborgh,Paul A. Baldock,Paul A. Baldock,Michael J. Rogers,Michael J. Rogers,Colby L. Eaton,Karin Vanderkerken,Allison R. Pettit,Julian M.W. Quinn,Andrew C.W. Zannettino,Tri Giang Phan,Tri Giang Phan,Peter I. Croucher,Peter I. Croucher +28 more
TL;DR: It is demonstrated that dormancy is a reversible state that is switched 'on' by engagement with bone-lining cells or osteoblasts, and switched ‘off' by osteoclasts remodelling the endosteal niche.
Journal ArticleDOI
Targeting the multiple myeloma hypoxic niche with TH-302, a hypoxia-activated prodrug.
Jinsong Hu,Jinsong Hu,Damian Handisides,Els Van Valckenborgh,Hendrik De Raeve,Eline Menu,Isabelle Vande Broek,Qian Liu,Jessica D Sun,Benjamin Van Camp,Charles P. Hart,Karin Vanderkerken +11 more
TL;DR: The data support that hypoxia-activated treatment with TH-302 provides a potential new treatment option for MM and triggers apoptosis of the MM cells within the bone marrow microenvironment and decreases paraprotein secretion.
Journal ArticleDOI
The involvement of stromal derived factor 1alpha in homing and progression of multiple myeloma in the 5TMM model
Eline Menu,Kewal Asosingh,Stefano Indraccolo,Hendrik De Raeve,Ivan Van Riet,Els Van Valckenborgh,Isabelle Vande Broek,Nobutaka Fujii,Hirokazu Tamamura,Benjamin Van Camp,Karin Vanderkerken +10 more
TL;DR: These data demonstrate that SDF1alpha/CXCR4 is involved in the homing and the expansion of MM cells and could be useful in synergy with other anti-neoplastic treatments targeting the bone marrow microenvironment.