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Werner Hacke
Researcher at Heidelberg University
Publications - 688
Citations - 93115
Werner Hacke is an academic researcher from Heidelberg University. The author has contributed to research in topics: Stroke & Thrombolysis. The author has an hindex of 123, co-authored 656 publications receiving 84593 citations. Previous affiliations of Werner Hacke include University Hospital Heidelberg & Steklov Mathematical Institute.
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Factors associated with major bleeding events: insights from the ROCKET AF trial (rivaroxaban once-daily oral direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation).
Shaun G. Goodman,Daniel Wojdyla,Jonathan P. Piccini,Harvey D. White,John F. Paolini,Christopher C. Nessel,Scott D. Berkowitz,Kenneth W. Mahaffey,Manesh R. Patel,Matthew W. Sherwood,Richard C. Becker,Jonathan L. Halperin,Werner Hacke,Daniel E. Singer,Graeme J. Hankey,Günter Breithardt,Keith A.A. Fox,Robert M. Califf,Rocket Af Investigators +18 more
TL;DR: Rivaroxaban and warfarin had similar risk for major/nonmajor clinically relevant bleeding and age, sex, DBP, prior GI bleeding, prior acetylsalicylic acid use, and anemia were associated with the risk of major bleeding.
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Bleeding Complications With Dual Antiplatelet Therapy Among Patients With Stable Vascular Disease or Risk Factors for Vascular Disease Results From the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance (CHARISMA) Trial
Peter B. Berger,Deepak L. Bhatt,Valentin Fuster,P. Gabriel Steg,Keith A.A. Fox,Mingyuan Shao,Danielle M. Brennan,Werner Hacke,Gilles Montalescot,Steven R. Steinhubl,Eric J. Topol +10 more
TL;DR: In the CHARISMA trial, there was an increased risk of bleeding with long-term clopidogrel and moderate bleeding was strongly associated with mortality.
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Contemporary Outcome Measures in Acute Stroke Research: Choice of Primary Outcome Measure
Kennedy R. Lees,Philip M.W. Bath,Peter D. Schellinger,Daniel M. Kerr,Rachael L. Fulton,Werner Hacke,David B. Matchar,Ruchir Sehra,Danilo Toni +8 more
TL;DR: The modified Rankin Scale is imperfect but should be retained in its present form for comparability with existing treatment comparisons, and should be included in most acute trials, without seeking to restrict options for special circumstances.
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Correlation of imaging and histopathology of thrombi in acute ischemic stroke with etiology and outcome: a systematic review
Waleed Brinjikji,Sharon Duffy,Anthony M. Burrows,Werner Hacke,David S Liebeskind,Charles B. L. M. Majoie,Diederik W.J. Dippel,Adnan H. Siddiqui,Pooja Khatri,Blaise Baxter,Raul Nogeuira,Matthew J. Gounis,Tudor G Jovin,David F. Kallmes +13 more
TL;DR: The hyperdense artery sign is associated with RBC-rich thrombi and improved recanalization rates, however, there was no association between the histopathological characteristics of thROMbi and stroke etiology and angiographic outcomes.
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Brain temperature monitoring and modulation in patients with severe MCA infarction
TL;DR: After MCA stroke, human intracerebral temperature is higher than central body-core temperature, and there is also a temperature gradient within the brain, with the ventricles warmer than the surface.