X
X Yao
Researcher at University of Oxford
Publications - 24
Citations - 1113
X Yao is an academic researcher from University of Oxford. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 2, co-authored 3 publications receiving 624 citations.
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Journal ArticleDOI
Broad and strong memory CD4 + and CD8 + T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19.
Yanchun Peng,Alexander J. Mentzer,G Liu,G Liu,X Yao,Z Yin,D Dong,D Dong,Wanwisa Dejnirattisai,T Rostron,P Supasa,C Liu,Cesar Lopez-Camacho,J Slon-Campos,Yuguang Zhao,David I. Stuart,Guido C. Paesen,Jonathan M. Grimes,Alfred A. Antson,Oliver W. Bayfield,Hawkins Dedp.,Ker D-S.,B Wang,Lance Turtle,Krishanthi Subramaniam,Paul Thomson,P Zhang,Christina Dold,Jeremy Ratcliff,Peter Simmonds,T I de Silva,Paul Sopp,Dannielle Wellington,U S Rajapaksa,Chen Y-L.,Mariolina Salio,Giorgio Napolitani,Wayne Paes,Persephone Borrow,Benedikt M. Kessler,J W Fry,N F Schwabe,Malcolm G Semple,Malcolm G Semple,J K Baillie,Shona C Moore,Openshaw Pjm.,M A Ansari,Susanna Dunachie,Eleanor Barnes,John Frater,G Kerr,Philip J. R. Goulder,T Lockett,R Levin,Y Zhang,Y Zhang,R Jing,Ho L-P.,Richard J. Cornall,Christopher P. Conlon,Paul Klenerman,Gavin R. Screaton,Juthathip Mongkolsapaya,Andrew J. McMichael,Julian C. Knight,Graham S. Ogg,Tao Dong +67 more
TL;DR: The identification of T cell responses associated with milder disease will support an understanding of protective immunity and highlights the potential of including non-spike proteins within future COVID-19 vaccine design.
Posted ContentDOI
Broad and strong memory CD4+and CD8+T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients
Yanchun Peng,Alexander J. Mentzer,Gu Liu,Gu Liu,X Yao,Zixi Yin,D Dong,D Dong,Wanwisa Dejnirattisai,T Rostron,P Supasa,Chang Liu,Cesar Lopez-Camacho,J Slon-Campos,Yuguang Zhao,David I. Stuart,G Paeson,Jonathan M. Grimes,F Antson,Oliver W. Bayfield,Hawkins Dedp.,Ker D-S.,Lance Turtle,Krishanthi Subramaniam,Paul Thomson,Peijun Zhang,Christina Dold,Jeremy Ratcliff,Peter Simmonds,T I de Silva,Paul Sopp,Dannielle Wellington,U S Rajapaksa,Chen Y-L.,Mariolina Salio,Giorgio Napolitani,Wayne Paes,Persephone Borrow,Benedikt M. Kessler,J W Fry,N F Schwabe,Malcolm G Semple,Malcolm G Semple,Kenneth Baillie,Shona C Moore,Openshaw Pjm.,A Ansari,Susanna Dunachie,Eleanor Barnes,John Frater,Georgina Kerr,P Goulder,T Lockett,R Levin,Richard J. Cornall,Christopher P. Conlon,Paul Klenerman,Andrew J. McMichael,Gavin R. Screaton,Juthathip Mongkolsapaya,Julian C. Knight,Graham S. Ogg,Tao Dong +62 more
TL;DR: The identification of T cell specificity and functionality associated with milder disease, highlights the potential importance of including non-spike proteins within future COVID-19 vaccine design.
Journal ArticleDOI
The bacteriology of pleural infection (TORPIDS): an exploratory metagenomics analysis through next generation sequencing
Nikolaos I. Kanellakis,John M. Wrightson,Stephen Gerry,Nicholas E. Ilott,John P. Corcoran,Eihab O Bedawi,Rachelle Asciak,Andrey Nezhentsev,Anand Sundaralingam,Robert J. Hallifax,Greta Economides,Lucy R Bland,Elizabeth Daly,X Yao,Nick A Maskell,Robert F. Miller,Derrick W. Crook,Timothy S. C. Hinks,Tao Dong,Ioannis Psallidas,Najib M. Rahman +20 more
TL;DR: Pleural infection is a predominantly polymicrobial infection, explaining the requirement for broad spectrum antibiotic cover in most individuals, and dominance of Enterobacteriaceae was associated with higher risk of death and lower survival.
Journal ArticleDOI
966: efficacy and safety of extended induction treatment with upadacitinib 45 mg once daily followed by maintenance upadacitinib 15 or 30 mg once daily in patients with moderately to severely active ulcerative colitis
Severine Vermeire,Silvio Danese,Wen Zhou,Justin Klaff,Dapo Ilo,X Yao,Gweneth F. Levy,Peter D.R. Higgins,Edward V. Loftus,Remo Panaccione +9 more
Posted ContentDOI
Memory cytotoxic SARS-CoV-2 spike protein-specific CD4+ T cells associate with viral control
Tao Dong,Guihai Liu,Suet Ling Felce,X Yao,Zixi Yin,Anastasia Fries,Alexander J. Mentzer,D Dong,Wenbo Wang,Wanwisa Dejnirattisai,P Supasa,Changxiao Liu,Peter A.C. Wing,Tim Rostron,C Waugh,Sally Ann Clark,Kevin Clark,Paul Sopp,Philip Hublitz,Ryan D. Beveridge,Jeremy Fry,Jane A. McKeating,Juthathip Mongkolsapaya,Gavin R. Screaton,Graham S. Ogg,Julian C. Knight,Yanchun Peng +26 more
TL;DR: This study investigates CD4+ T-cell responses to three dominant SARS-CoV-2 epitopes and evaluates antiviral activity, including cytotoxicity and antiviral cytokine production, and highlights the unique features of cytotoxic CD4-cells that use distinct functional pathways, providing preventative and therapeutic opportunities.