T
T Lockett
Researcher at University of Oxford
Publications - 7
Citations - 1637
T Lockett is an academic researcher from University of Oxford. The author has contributed to research in topics: Cytotoxic T cell & CD8. The author has an hindex of 5, co-authored 7 publications receiving 899 citations.
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Journal ArticleDOI
Broad and strong memory CD4 + and CD8 + T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19.
Yanchun Peng,Alexander J. Mentzer,G Liu,G Liu,X Yao,Z Yin,D Dong,D Dong,Wanwisa Dejnirattisai,T Rostron,P Supasa,C Liu,Cesar Lopez-Camacho,J Slon-Campos,Yuguang Zhao,David I. Stuart,Guido C. Paesen,Jonathan M. Grimes,Alfred A. Antson,Oliver W. Bayfield,Hawkins Dedp.,Ker D-S.,B Wang,Lance Turtle,Krishanthi Subramaniam,Paul Thomson,P Zhang,Christina Dold,Jeremy Ratcliff,Peter Simmonds,T I de Silva,Paul Sopp,Dannielle Wellington,U S Rajapaksa,Chen Y-L.,Mariolina Salio,Giorgio Napolitani,Wayne Paes,Persephone Borrow,Benedikt M. Kessler,J W Fry,N F Schwabe,Malcolm G Semple,Malcolm G Semple,J K Baillie,Shona C Moore,Openshaw Pjm.,M A Ansari,Susanna Dunachie,Eleanor Barnes,John Frater,G Kerr,Philip J. R. Goulder,T Lockett,R Levin,Y Zhang,Y Zhang,R Jing,Ho L-P.,Richard J. Cornall,Christopher P. Conlon,Paul Klenerman,Gavin R. Screaton,Juthathip Mongkolsapaya,Andrew J. McMichael,Julian C. Knight,Graham S. Ogg,Tao Dong +67 more
TL;DR: The identification of T cell responses associated with milder disease will support an understanding of protective immunity and highlights the potential of including non-spike proteins within future COVID-19 vaccine design.
Journal ArticleDOI
Performance characteristics of five immunoassays for SARS-CoV-2: a head-to-head benchmark comparison
Mark A. Ainsworth,Monique Andersson,Monique Andersson,Kathryn Auckland,J K Baillie,Eleanor Barnes,Sally Beer,A Beveridge,Sadia Bibi,L Blackwell,M Borak,Abbie Bown,Tim Brooks,Nicola A. Burgess-Brown,S Camara,Matthew Catton,K K Chau,Thomas Christott,Elizabeth A. Clutterbuck,Jesse Coker,Richard J. Cornall,Stuart Cox,D Crawford-Jones,Derrick W. Crook,Silvia D'Arcangelo,W Dejnirattsai,Dequaire Jmm.,S Dimitriadis,Kate E. Dingle,George Doherty,Christina Dold,Tao Dong,Susanna Dunachie,Daniel Ebner,M Emmenegger,A Espinosa,David W Eyre,Rory Fairhead,S Fassih,Conor Feehily,S Felle,Alejandra Fernández-Cid,M Fernandez Mendoza,T H Foord,T Fordwoh,D Fox McKee,John Frater,V Gallardo Sanchez,N Gent,D Georgiou,Christopher J. Groves,Bassam Hallis,P M Hammond,Stephanie B Hatch,Heli Harvala,Jennifer Hill,Sarah Hoosdally,B Horsington,Alison Howarth,Tim James,Katie Jeffery,E Y Jones,Anita Justice,F Karpe,James Kavanagh,D S Kim,R Kirton,Paul Klenerman,Julian C. Knight,L Koukouflis,Andrew J Kwok,U Leuschner,R Levin,A Linder,T Lockett,Sheila F Lumley,S Marinou,Brian D. Marsden,José William Martínez,L Martins Ferreira,L Mason,Philippa C Matthews,Alexander J. Mentzer,A Mobbs,Juthathip Mongkolsapaya,J Morrow,Mukhopadhyay Smm.,Matt J. Neville,Sarah Oakley,Marta Oliveira,Ashley Otter,K Paddon,J Pascoe,Y Peng,E Perez,Prem Perumal,Peto Tea.,H Pickford,Rutger J. Ploeg,Andrew J. Pollard,Alex J. Richardson,Thomas G Ritter,Devender Roberts,Gillian Rodger,Christine S. Rollier,Cathy Rowe,Justine K. Rudkin,Gavin R. Screaton,Malcolm G Semple,Alex Sienkiewicz,L Silva-Reyes,Donal T. Skelly,A Sobrino Diaz,L Stafford,Lisa Stockdale,Nicole Stoesser,Teresa L Street,David I. Stuart,Angela Sweed,Aimee R. Taylor,H Thraves,H P Tsang,M K Verheul,Richard Vipond,Timothy M Walker,Susan Wareing,Y Warren,Carrow I. Wells,C Wilson,K Withycombe,R K Young +130 more
TL;DR: Four commercial, widely available assays and a scalable 384-well ELISA can be used for SARS-CoV-2 serological testing to achieve sensitivity and specificity of at least 98%.
Journal ArticleDOI
COVID-19: Rapid antigen detection for SARS-CoV-2 by lateral flow assay: A national systematic evaluation of sensitivity and specificity for mass-testing.
T Peto,Dominic Affron,Babak Afrough,Anita Agasu,Mark A. Ainsworth,Alison Allanson,Kate Allen,Collette Allen,Lorraine Archer,Natasha Ashbridge,Iman Aurfan,Miriam Avery,Ellena Badenoch,Priya Bagga,Rishab Balaji,Ella Baldwin,Sophie Barraclough,Carol Beane,John I. Bell,Tracy Benford,Susan Bird,Marina Bishop,Angela Bloss,Richard Body,Rosie Boulton,Abbie Bown,Carla Bratten,Chris Bridgeman,Dominic Britton,Tim Brooks,Margaret Broughton-Smith,Pauline Brown,Beverley Buck,Elaine Butcher,Wendy Byrne,Gloria Calderon,Siobhan Campbell,Olivia Carr,Penny Carter,Daniel P. Carter,Megan Cathrall,Matthew Catton,Jim Chadwick,David Chapman,Kevin K Chau,Tanzina Chaudary,Shaolin Chidavaenzi,Samatha Chilcott,Bea Choi,Hannah Claasen,Simon Clark,Richard Clarke,Dawn Clarke,Richard Clayton,Kayleigh Collins,Rima Colston,James Connolly,Eloïse Cook,Marie Corcoran,Ben Corley,Laura Costello,Caroline Coulson,Ant Crook,Derrick W. Crook,Silvia D'Arcangelo,Mary-Anne Darby,John Davis,Rosaline de Koning,Pauline Derbyshire,Pam Devall,Mark Dolman,Natalie Draper,Mark Driver,Sarah Dyas,Emily Eaton,Joy Edwards,Ruth Elderfield,Kate Ellis,Graham Ellis,Sue Elwell,Rachel Evans,Becky Evans,Marion Evans,Ranoromanana Evans,David W Eyre,Codie Fahey,Vanessa Fenech,Janet Field,Alice Field,Tom Foord,Tom Fowler,Mollie French,Hannah Fuchs,Jasmine Gan,Joseph Gernon,Geeta Ghadiali,Narindar Ghuman,Kerry Gibbons,Gurvinder Gill,Kate Gilmour,Anika Goel,Sally Gordon,Tillie Graham,Alexander Grassam-Rowe,David Green,Anna Gronert,Tegan Gumsley-Read,Claire Hall,Bassam Hallis,Sally Hammond,Peter Hammond,Beth Hanney,Victoria Hardy,Gabriella Harker,Andrew Harris,May Havinden-Williams,Elena Hazell,Joanne Henry,Kim Hicklin,Kelly Hollier,Ben Holloway,Sarah Hoosdally,Susan Hopkins,Lucy Hughes,Steve Hurdowar,Sally-Anne Hurford,Joanne Jackman,Harriet Jackson,Ruth Johns,Susan Johnston,Juliet Jones,Tinashe Kanyowa,Katie Keating-Fedders,Sharon Kempson,Iftikhar Khan,Beinn Khulusi,Thomas Knight,Anuradha Krishna,Patrick Lahert,Zoe Lampshire,Daniel Lasserson,Kirsten Lee,Lennard Y. W. Lee,Arabella Legard,Cristina Leggio,Justin Liu,T Lockett,Christopher H. Logue,Vanessa Lucas,Sheila F Lumley,Vindhya Maripuri,Des Markham,Emma Marshall,Philippa C Matthews,Sarah Mckee,Deborah F. McKee,Neil McLeod,Antoinette McNulty,Freddie Mellor,Rachel Michel,Alex Mighiu,Julie Miller,Zarina Mirza,Heena Mistry,Jane Mitchell,Mika Erik Moeser,Sophie Moore,Akhila Muthuswamy,Daniel Myers,Gemma Nanson,Mike Newbury,Scott Nicol,Harry Nuttall,Jewel Jones Nwanaforo,Louise Oliver,Wendy Osbourne,Jake Osbourne,Ashley Otter,Jodie Owen,Sulaksan Panchalingam,Dimitris Papoulidis,Juan Dobaldo Pavon,Arro Peace,Karen Pearson,Liam J Peck,Ashley Pegg,Suzannah Pegler,Helen Permain,Prem Perumal,Leon Peto,Tim E. A. Peto,Thanh Pham,H Pickford,Mark Pinkerton,Michelle Platton,Ashley Price,Emily A. Protheroe,Hellen Purnell,Lottie Rawden,Sara Read,Charles Reynard,Susan Ridge,Tom G. Ritter,James O. Robinson,Patrick Robinson,Gillian Rodger,Cathy Rowe,Bertie Rowell,Alexandra Rowlands,Sarah Sampson,Kathryn J Saunders,Rachel Sayers,Jackie Sears,Richard Sedgewick,Laura Seeney,Amanda Selassie,Lloyd Shail,Jane Shallcross,Lucy Sheppard,Anna Sherkat,Shelha Siddiqui,Alex Sienkiewicz,Lavanya Sinha,Jennifer Smith,Ella Smith,Emma Stanton,Thomas Starkey,Aleksander Stawiarski,Amelia Sterry,Joe Stevens,Mark Stockbridge,Nicole Stoesser,Anila Sukumaran,Angela Sweed,Sami Tatar,Hema Thomas,Carly Tibbins,Sian Tiley,Julie Timmins,Cara Tomas-Smith,Oliver Topping,Elena Turek,Toi Neibler,Kate Trigg-Hogarth,Elizabeth Truelove,Chris D. Turnbull,David Tyrrell,Alison Vaughan,John Vertannes,Richard Vipond,Linda Wagstaff,Joanne Waldron,Philip Walker,Ann Sarah Walker,Mary Walters,Jenny Wang,Ellie Watson,Kate Webberley,Kimerbley Webster,Grace Westland,Ian Wickens,Jane Willcocks,Herika Willis,Stephen W. Wilson,Barbara Wilson,Louise Woodhead,Deborah Wright,Bindhu Xavier,Fiona Yelnoorkar,Lisa Zeidan,Rangeni Zinyama +270 more
TL;DR: In this article, the authors evaluated the performance of Lateral flow device (LFD) immunoassays for SARS-CoV-2 infection and found that they have promising performance characteristics for mass population testing and can be used to identify infectious positive individuals.
Posted ContentDOI
Broad and strong memory CD4+and CD8+T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients
Yanchun Peng,Alexander J. Mentzer,Gu Liu,Gu Liu,X Yao,Zixi Yin,D Dong,D Dong,Wanwisa Dejnirattisai,T Rostron,P Supasa,Chang Liu,Cesar Lopez-Camacho,J Slon-Campos,Yuguang Zhao,David I. Stuart,G Paeson,Jonathan M. Grimes,F Antson,Oliver W. Bayfield,Hawkins Dedp.,Ker D-S.,Lance Turtle,Krishanthi Subramaniam,Paul Thomson,Peijun Zhang,Christina Dold,Jeremy Ratcliff,Peter Simmonds,T I de Silva,Paul Sopp,Dannielle Wellington,U S Rajapaksa,Chen Y-L.,Mariolina Salio,Giorgio Napolitani,Wayne Paes,Persephone Borrow,Benedikt M. Kessler,J W Fry,N F Schwabe,Malcolm G Semple,Malcolm G Semple,Kenneth Baillie,Shona C Moore,Openshaw Pjm.,A Ansari,Susanna Dunachie,Eleanor Barnes,John Frater,Georgina Kerr,P Goulder,T Lockett,R Levin,Richard J. Cornall,Christopher P. Conlon,Paul Klenerman,Andrew J. McMichael,Gavin R. Screaton,Juthathip Mongkolsapaya,Julian C. Knight,Graham S. Ogg,Tao Dong +62 more
TL;DR: The identification of T cell specificity and functionality associated with milder disease, highlights the potential importance of including non-spike proteins within future COVID-19 vaccine design.
Journal ArticleDOI
A haemagglutination test for rapid detection of antibodies to SARS-CoV-2.
Alain Townsend,Alain Townsend,Pramila Rijal,Pramila Rijal,Julie Xiao,Tiong Kit Tan,Huang K-Ya.,Huang K-Ya.,Lisa Schimanski,Lisa Schimanski,Jiangdong Huo,Nimesh Gupta,Rolle Rahikainen,Philippa C Matthews,Philippa C Matthews,Derrick W. Crook,Sarah Hoosdally,Sarah Hoosdally,Susanna Dunachie,Eleanor Barnes,Teresa L Street,Christopher P. Conlon,John Frater,Carolina V. Arancibia-Cárcamo,Justine K. Rudkin,Nicole Stoesser,F Karpe,F Karpe,Matt J. Neville,Rutger J. Ploeg,Marta S Oliveira,David J. Roberts,David J. Roberts,Abigail Lamikanra,H P Tsang,Abbie Bown,Richard Vipond,Alexander J. Mentzer,Julian C. Knight,Julian C. Knight,Andrew J Kwok,Gavin R. Screaton,Gavin R. Screaton,Juthathip Mongkolsapaya,Juthathip Mongkolsapaya,Wanwisa Dejnirattisai,P Supasa,Paul Klenerman,Christina Dold,J K Baillie,Shona C Moore,Openshaw Pjm.,Malcolm G Semple,Turtle Lcw.,Mark A. Ainsworth,A Allcock,Sally Beer,S Bibi,Donal T. Skelly,L Stafford,Katie Jeffrey,Denise O'Donnell,Elizabeth A. Clutterbuck,A Espinosa,Maria Fernandez Mendoza,D Georgiou,T Lockett,Jose Vicente Martinez,E Perez,V Gallardo Sanchez,G Scozzafava,A Sobrinodiaz,H Thraves,Etienne Joly +73 more
TL;DR: A quantitative Haemagglutination test (HAT) was proposed in this article for the detection of antibodies to the receptor binding domain of the SARS-CoV-2 spike protein.