Xiaoli Yi

TL;DR: A 3p21.31 gene cluster is identified as a genetic susceptibility locus in patients with Covid-19 with respiratory failure and a potential involvement of the ABO blood-group system is confirmed.

TL;DR: The first robust genetic susceptibility loci for the development of respiratory failure in Covid-19 are reported, and Identified variants may help guide targeted exploration of severe Covd-19 pathophysiology.

TL;DR: An extended GWAS meta-analysis of a well-characterized cohort of COVID-19 patients with respiratory failure and population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen (HLA) region and the SARS-CoV-2 peptidome is described.

TL;DR: In this article , a detailed protocol of pressure cycling technology (PCT)-assisted sample preparation for proteomic analysis of biopsy tissues is described, where a piece of fresh frozen or formalin-fixed paraffin-embedded tissue weighing ~0.1-2 mg is placed in a 150 μL pressure-resistant tube called a PCT-MicroTube with proper lysis buffer.

TL;DR: In this article , the authors employ genome-wide profiling after acute depletion of Pol I, Pol II, or Pol III to assess cross-regulatory effects between these polymerases, and they find that these enzymes mainly affect the transcription of their own target genes, while certain genes are transcribed by the other polymerases.