Aurora Solier

TL;DR: A 3p21.31 gene cluster is identified as a genetic susceptibility locus in patients with Covid-19 with respiratory failure and a potential involvement of the ABO blood-group system is confirmed.

TL;DR: The first robust genetic susceptibility loci for the development of respiratory failure in Covid-19 are reported, and Identified variants may help guide targeted exploration of severe Covd-19 pathophysiology.

TL;DR: An extended GWAS meta-analysis of a well-characterized cohort of COVID-19 patients with respiratory failure and population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen (HLA) region and the SARS-CoV-2 peptidome is described.

TL;DR: In this paper, an extended GWAS meta-analysis of 3,260 COVID-19 patients with respiratory failure and 12,483 population controls from Italy, Spain, Norway and Germany/Austria, as well as hypothesis-driven targeted analysis of the human leukocyte antigen (HLA) region and chromosome Y haplotypes.

TL;DR: In this paper , the authors used multivariable logistic regression to assess the independent association between findings supporting an alternative diagnosis to PE and a composite of readmission for COPD or death within 90 days after randomization.