Xiaotian Yao

TL;DR: A method for analyzing the cancer genome at a single-cell nucleotide level is described and essential thrombocythemia-related candidate mutations such as SESN2 and NTRK1 are identified, which may be involved in neoplasm progression.

TL;DR: With careful monitoring via whole-genome sequencing it is possible to apply genome editing to human pluripotent cells with minimal impact on genomic mutational load, and a TALEN-HDAdV hybrid vector is developed, which significantly increased gene-correction efficiency in hiPSCs.

TL;DR: This study provides the first exome-wide evidence at single-cell level supporting that colon cancer could be of a biclonal origin, and suggests that low-prevalence mutations in a cohort may also play important protumorigenic roles at the individual level.

TL;DR: Using genomic, transcriptome, and epigenomic comparisons of EBV infected vs noninfected gastric cancer cells and tumor samples, alterations in genes, gene expression, and methylation that affect different signaling networks are identified.

TL;DR: A simple and effective non-invasively inferred fetal genotype and haplotype under different situations of parental heterozygosity is presented and provides a useful strategy forNon-invasive whole fetal genome recovery.