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Ya-Juan Hao
Researcher at Chinese Academy of Sciences
Publications - 7
Citations - 4782
Ya-Juan Hao is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: N6-Methyladenosine & MRNA methylation. The author has an hindex of 5, co-authored 6 publications receiving 3177 citations. Previous affiliations of Ya-Juan Hao include Beijing Institute of Genomics.
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Journal ArticleDOI
ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
Guanqun Zheng,John Arne Dahl,Yamei Niu,Peter Fedorcsak,Chun-Min Huang,Charles J. Li,Cathrine Broberg Vågbø,Yue Shi,Yue Shi,Wen-Ling Wang,Wen-Ling Wang,Shuhui Song,Zhike Lu,Ralph P. G. Bosmans,Qing Dai,Ya-Juan Hao,Ya-Juan Hao,Xin Yang,Xin Yang,Wenming Zhao,Wei-Min Tong,Xiu-Jie Wang,Florian Bogdan,Kari Furu,Ye Fu,Guifang Jia,Xu Zhao,Xu Zhao,Jun Liu,Hans E. Krokan,Arne Klungland,Yun-Gui Yang,Yun-Gui Yang,Chuan He +33 more
TL;DR: The discovery of ALKBH5 as another mammalian demethylase that oxidatively reverses m(6)A in mRNA in vitro and in vivo strongly suggests that the reversible m( 6)A modification has fundamental and broad functions in mammalian cells.
Journal ArticleDOI
Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing.
Wen Xiao,Samir Adhikari,Samir Adhikari,Ujwal Dahal,Ujwal Dahal,Yu-Sheng Chen,Yu-Sheng Chen,Ya-Juan Hao,Ya-Juan Hao,Bao-Fa Sun,Hui-Ying Sun,Hui-Ying Sun,Ang Li,Ang Li,Xiao-Li Ping,Weiyi Lai,Xing Wang,Xing Wang,Hai-Li Ma,Hai-Li Ma,Chun-Min Huang,Ying Yang,Niu Huang,Guibin Jiang,Hailin Wang,Qi Zhou,Xiu-Jie Wang,Yong-Liang Zhao,Yun-Gui Yang,Yun-Gui Yang +29 more
TL;DR: The findings provide the direct evidence that m(6)A reader YTHDC1 regulates mRNA splicing through recruiting and modulating pre-mRNA splicing factors for their access to the binding regions of targeted mRNAs.
Journal ArticleDOI
FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis
Xu Zhao,Ying Yang,Bao-Fa Sun,Yue Shi,Xin Yang,Wen Xiao,Ya-Juan Hao,Xiao-Li Ping,Yu-Sheng Chen,Wenjia Wang,Kang-Xuan Jin,Xing Wang,Chun-Min Huang,Yu Fu,Xiaomeng Ge,Shuhui Song,Hyun Seok Jeong,Hiroyuki Yanagisawa,Yamei Niu,Guifang Jia,Wei Wu,Wei-Min Tong,Akimitsu Okamoto,Chuan He,Jannie M. Rendtlew Danielsen,Xiu-Jie Wang,Yun-Gui Yang +26 more
TL;DR: Findings provide compelling evidence that FTO-dependent m6A demethylation functions as a novel regulatory mechanism of RNA processing and plays a critical role in the regulation of adipogenesis.
Journal ArticleDOI
m6A RNA Methylation Is Regulated by MicroRNAs and Promotes Reprogramming to Pluripotency
Tong Chen,Ya-Juan Hao,Ya-Juan Hao,Ying Zhang,Miao-Miao Li,Miao-Miao Li,Meng Wang,Weifang Han,Yong-Sheng Wu,Ying Lv,Ying Lv,Jie Hao,Libin Wang,Ang Li,Ang Li,Ying Yang,Ying Yang,Kang-Xuan Jin,Kang-Xuan Jin,Xu Zhao,Xu Zhao,Yuhuan Li,Xiao-Li Ping,Xiao-Li Ping,Weiyi Lai,Li-Gang Wu,Guibin Jiang,Hailin Wang,Lisi Sang,Xiu-Jie Wang,Yun-Gui Yang,Qi Zhou +31 more
TL;DR: A role for miRNAs is uncovered in regulating m( 6)A formation of mRNAs and provide a foundation for future functional studies of m(6)A modification in cell reprogramming.
Journal ArticleDOI
Correctionm6A RNA Methylation Is Regulated by MicroRNAs and Promotes Reprogramming to Pluripotency
Tong Chen,Ya-Juan Hao,Ying Zhang,Miao-Miao Li,Meng Wang,Weifang Han,Yong-Sheng Wu,Ying Lv,Jie Hao,Libin Wang,Ang Li,Ying Yang,Kang-Xuan Jin,Xu Zhao,Yuhuan Li,Xiao-Li Ping,Weiyi Lai,Li-Gang Wu,Qi Zhou +18 more