Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing.
Wen Xiao,Samir Adhikari,Samir Adhikari,Ujwal Dahal,Ujwal Dahal,Yu-Sheng Chen,Yu-Sheng Chen,Ya-Juan Hao,Ya-Juan Hao,Bao-Fa Sun,Hui-Ying Sun,Hui-Ying Sun,Ang Li,Ang Li,Xiao-Li Ping,Weiyi Lai,Xing Wang,Xing Wang,Hai-Li Ma,Hai-Li Ma,Chun-Min Huang,Ying Yang,Niu Huang,Guibin Jiang,Hailin Wang,Qi Zhou,Xiu-Jie Wang,Yong-Liang Zhao,Yun-Gui Yang,Yun-Gui Yang +29 more
TLDR
The findings provide the direct evidence that m(6)A reader YTHDC1 regulates mRNA splicing through recruiting and modulating pre-mRNA splicing factors for their access to the binding regions of targeted mRNAs.About:
This article is published in Molecular Cell.The article was published on 2016-02-18 and is currently open access. It has received 1244 citations till now. The article focuses on the topics: RNA Splicing Factors & Exonic splicing enhancer.read more
Citations
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Journal ArticleDOI
Dynamic RNA Modifications in Gene Expression Regulation
TL;DR: Roles for mRNA modification in nearly every aspect of the mRNA life cycle, as well as in various cellular, developmental, and disease processes are revealed.
Journal ArticleDOI
Recognition of RNA N 6 -methyladenosine by IGF2BP proteins enhances mRNA stability and translation
Huilin Huang,Huilin Huang,Hengyou Weng,Hengyou Weng,Wen-Ju Sun,Xi Qin,Xi Qin,Hailing Shi,Hailing Shi,Huizhe Wu,Huizhe Wu,Huizhe Wu,Boxuan Simen Zhao,Boxuan Simen Zhao,Ana Mesquita,Chang Liu,Chang Liu,Celvie L. Yuan,Yueh-Chiang Hu,Stefan Hüttelmaier,Jennifer R. Skibbe,Rui Su,Rui Su,Xiaolan Deng,Xiaolan Deng,Xiaolan Deng,Lei Dong,Lei Dong,Miao Sun,Chenying Li,Chenying Li,Chenying Li,Sigrid Nachtergaele,Sigrid Nachtergaele,Yungui Wang,Yungui Wang,Chao Hu,Chao Hu,Kyle Ferchen,Kenneth D. Greis,Xi Jiang,Xi Jiang,Minjie Wei,Liang-Hu Qu,Jun-Lin Guan,Chuan He,Chuan He,Jian-Hua Yang,Jianjun Chen,Jianjun Chen +49 more
TL;DR: This work reports the insulin-like growth factor 2 mRNA-binding proteins as a distinct family of m6A readers that target thousands of mRNA transcripts through recognizing the consensus GG(m6A)C sequence, and identifies IGF2BPs as an additional class of N6-methyladenosine (m 6A) reader proteins.
Journal ArticleDOI
Post-transcriptional gene regulation by mRNA modifications
TL;DR: N6-adenosine methylation directs mRNAs to distinct fates by grouping them for differential processing, translation and decay in processes such as cell differentiation, embryonic development and stress responses.
Journal ArticleDOI
Reading, writing and erasing mRNA methylation.
TL;DR: New and emerging methods to characterize and quantify the epitranscriptome are reviewed, and new concepts — in some cases, controversies — are discussed regarding the authors' understanding of the mechanisms and functions of m6A readers, writers and erasers are discussed.
Journal ArticleDOI
m 6 A RNA methylation promotes XIST -mediated transcriptional repression
Deepak P. Patil,Chun-Kan Chen,Brian F. Pickering,Amy Y. M. Chow,Constanza Jackson,Mitchell Guttman,Samie R. Jaffrey +6 more
TL;DR: The long non-coding RNA X-inactive specific transcript (XIST) mediates the transcriptional silencing of genes on the X chromosome and is highly methylated with at least 78 N6-methyladenosine (m6A) residues, revealing a pathway of m6A formation and recognition required for XIST-mediated transcriptional repression.
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