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Yan Zhu
Researcher at Chinese Academy of Sciences
Publications - 30
Citations - 20744
Yan Zhu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Coronavirus & Medicine. The author has an hindex of 14, co-authored 20 publications receiving 14978 citations.
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Journal ArticleDOI
A pneumonia outbreak associated with a new coronavirus of probable bat origin
Peng Zhou,Xing-Lou Yang,Xian Guang Wang,Ben Hu,Lei Zhang,Wei Zhang,Hao Rui Si,Yan Zhu,Bei Li,Chao Lin Huang,Hui-Dong Chen,Jing Chen,Yun Luo,Hua Guo,Ren Di Jiang,Meiqin Liu,Ying Chen,Xu Rui Shen,Xi Wang,Xiao Shuang Zheng,Kai Zhao,Quanjiao Chen,Fei Deng,Lin Lin Liu,Bing Yan,Fa Xian Zhan,Yan-Yi Wang,Gengfu Xiao,Zhengli Shi +28 more
TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
Journal ArticleDOI
Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor
Xing-Yi Ge,Jia Lu Li,Xing-Lou Yang,Aleksei A. Chmura,Guangjian Zhu,Jonathan H. Epstein,Jonna A. K. Mazet,Ben Hu,Wei Zhang,Cheng Peng,Yu Ji Zhang,Chu Ming Luo,Bing Tan,Ning Wang,Yan Zhu,Gary Crameri,Shuyi Zhang,Lin-Fa Wang,Lin-Fa Wang,Peter Daszak,Zhengli Shi +20 more
TL;DR: These results provide the strongest evidence to date that Chinese horseshoe bats are natural reservoirs of SARS-CoV, and that intermediate hosts may not be necessary for direct human infection by some bat SL-CoVs, and highlight the importance of pathogen-discovery programs targeting high-risk wildlife groups in emerging disease hotspots.
Posted ContentDOI
Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin
Peng Zhou,Xing-Lou Yang,Xian Guang Wang,Ben Hu,Lei Zhang,Wei Zhang,Hao Rui Si,Yan Zhu,Bei Li,Chao Lin Huang,Hui-Dong Chen,Jing Chen,Yun Luo,Hua Guo,Ren Di Jiang,Meiqin Liu,Ying Chen,Xu Rui Shen,Xi Wang,Xiao Shuang Zheng,Kai Zhao,Quanjiao Chen,Fei Deng,Lin Lin Liu,Bing Yan,Fa Xian Zhan,Yan-Yi Wang,Gengfu Xiao,Zhengli Shi +28 more
TL;DR: The identification and characterization of a novel coronavirus (nCoV-2019) which caused an epidemic of acute respiratory syndrome in humans, in Wuhan, China, and it is confirmed that this novel CoV uses the same cell entry receptor, ACE2, as SARS-CoV.
Journal ArticleDOI
Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin.
Peng Zhou,Hang Fan,Tian Lan,Xing-Lou Yang,Weifeng Shi,Wei Zhang,Yan Zhu,Ya-Wei Zhang,Qingmei Xie,Shailendra Mani,Xiao-Shuang Zheng,Bei Li,Jinman Li,Hua Guo,Guangqian Pei,Xiaoping An,Jun-Wei Chen,Ling Zhou,Kai-jie Mai,Zixian Wu,Di Li,Danielle E. Anderson,Libiao Zhang,Shi-Yue Li,Zhiqiang Mi,Tongtong He,Feng Cong,Pengju Guo,Ren Huang,Yun Luo,Xiang-Ling Liu,Jing Chen,Yong Huang,Qiang Sun,Xianglilan Zhang,Yuan-Yuan Wang,Shaozhen Xing,Yan-Shan Chen,Yuan Sun,Juan Li,Peter Daszak,Lin-Fa Wang,Zhengli Shi,Yigang Tong,Jingyun Ma +44 more
TL;DR: Analysis of viral samples from deceased piglets shows that a bat coronav virus was responsible for an outbreak of fatal disease in China and highlights the importance of the identification of coronavirus diversity and distribution in bats in order to mitigate future outbreaks of disease.
Journal ArticleDOI
Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2.
Ren Di Jiang,Mei Qin Liu,Ying Chen,Chao Shan,Yi Wu Zhou,Xu Rui Shen,Li Qian,Lei Zhang,Yan Zhu,Hao Rui Si,Qi Wang,Juan Min,Xi Wang,Wei Zhang,Bei Li,Hua Jun Zhang,Ralph S. Baric,Peng Zhou,Xing-Lou Yang,Zhengli Shi +19 more
TL;DR: It is shown that pre-exposure to SARS-CoV-2 could protect mice from severe pneumonia and the hACE2 mouse would be a valuable tool for testing potential vaccines and therapeutics.