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Yizhi Sun
Researcher at University of Montana
Publications - 12
Citations - 149
Yizhi Sun is an academic researcher from University of Montana. The author has contributed to research in topics: China & Politics. The author has an hindex of 4, co-authored 5 publications receiving 71 citations. Previous affiliations of Yizhi Sun include Howard Hughes Medical Institute & Harvard University.
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Journal ArticleDOI
Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2
Ricardo A.P. de Pádua,Yizhi Sun,Yizhi Sun,Ingrid Marko,Warintra Pitsawong,John B. Stiller,Renee Otten,Dorothee Kern +7 more
TL;DR: NMR measurements and X-ray crystallography show that wild-type SHP2 dynamically exchanges between a closed inactive conformation and an open activated form and that the oncogenic E76K mutation shifts the equilibrium to the open state, which is reversed by binding of the allosteric inhibitor SHP099.
Journal ArticleDOI
Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine.
Yizhi Sun,Janane F. Rahbani,Mark P. Jedrychowski,Christopher L. Riley,Sara Vidoni,Dina Bogoslavski,Bo Hu,Phillip A. Dumesic,Xing Zeng,Alex Wang,Nelson H. Knudsen,Caroline R. Kim,Anthony Marasciullo,José Luis Millán,Edward T. Chouchani,Lawrence Kazak,Bruce M. Spiegelman +16 more
TL;DR: In this paper, the authors provided direct evidence for the molecular basis of this futile creatine cycling activity in mice, which was based on the super-stoichiometric relationship between the amount of creatine added to mitochondria and the quantity of oxygen consumed.
Journal ArticleDOI
Structure and unfolding of the third type III domain from human fibronectin.
TL;DR: The structure of 3FN3 is determined using nuclear magnetic resonance spectroscopy, and its stability, folding, and unfolding are investigated, finding the folding rate constant in the absence of denaturant is in the same range as those of other, more stable FN3 domains.
Journal ArticleDOI
Structural and functional characterization of the acidic region from the RIZ tumor suppressor.
Yizhi Sun,Jessica M. Stine,Daniel Z. Atwater,Ayesha Sharmin,J.B. Alexander Ross,Klára Briknarová +5 more
TL;DR: It is shown that AR is intrinsically disordered and that it binds the pocket domain with submicromolar affinity, and overall, the data provide clear evidence that RIZ is one of the few cellular proteins that can interact directly with the LXCXE-binding cleft on Rb.
Journal ArticleDOI
Architecture of the outbred brown fat proteome defines regulators of metabolic physiology
Haopeng Xiao,Luiz H. M. Bozi,Yizhi Sun,Christopher L. Riley,Vivek M. Philip,Mandy Chen,Jiaming Li,Tian Zhang,Evanna L. Mills,Margo P. Emont,Wenfei Sun,Anita Reddy,Ryan Garrity,Jiani Long,Tobias Becher,Laura Potano Vitas,Dina Laznik-Bogoslavski,Martha Ordonez,Xinyue Liu,Xiongbin Chen,Yun-Ting Wang,Wei-Hai Liu,Nhien Tran,Yitong Liu,Yan Zhang,Aaron M. Cypess,Andrew White,Yuchen He,Rebecca Awuor Deng,H. Schröder,Joao A. Paulo,Mark P. Jedrychowski,Alexander S. Banks,Yu-Hua Tseng,Paul Cohen,Linus T.-Y. Tsai,Evan D. Rosen,Samuel Klein,Maria Chondronikola,Fiona E. McAllister,Nicholas van Bruggen,Edward L. Huttlin,Bruce M. Spiegelman,Gary A. Churchill,Steven P. Gygi,Edward T. Chouchani +45 more
TL;DR: In this article , the authors performed deep quantitative proteomics of BAT across a cohort of 163 genetically defined diversity outbred mice, a model that parallels the genetic and phenotypic variation found in humans.