T
Tjoung Won Park-Simon
Researcher at Hannover Medical School
Publications - 13
Citations - 1997
Tjoung Won Park-Simon is an academic researcher from Hannover Medical School. The author has contributed to research in topics: Breast cancer & Genome-wide association study. The author has an hindex of 10, co-authored 13 publications receiving 1661 citations. Previous affiliations of Tjoung Won Park-Simon include Pomeranian Medical University.
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Journal ArticleDOI
Associations of Breast Cancer Risk Factors With Tumor Subtypes: A Pooled Analysis From the Breast Cancer Association Consortium Studies
Xiaohong R. Yang,Jenny Chang-Claude,Ellen L. Goode,Fergus J. Couch,Heli Nevanlinna,Roger L. Milne,Mia M. Gaudet,Marjanka K. Schmidt,Annegien Broeks,Angela Cox,Peter A. Fasching,Rebecca Hein,Amanda B. Spurdle,Fiona M. Blows,Kristy Driver,Dieter Flesch-Janys,J Heinz,Peter Sinn,Alina Vrieling,Tuomas Heikkinen,Kristiina Aittomäki,Päivi Heikkilä,Carl Blomqvist,Jolanta Lissowska,Beata Peplonska,S. Chanock,Jonine D. Figueroa,Louise A. Brinton,Per Hall,Kamila Czene,Keith Humphreys,Hatef Darabi,Jianjun Liu,Laura J. Van 'T Veer,Flora E. van Leeuwen,Irene L. Andrulis,Gord Glendon,Julia A. Knight,Anna Marie Mulligan,Frances P O'Malley,Nayana Weerasooriya,Esther M. John,Matthias W. Beckmann,Arndt Hartmann,Sebastian B. Weihbrecht,David L. Wachter,Sebastian M. Jud,Christian R. Loehberg,Laura Baglietto,Dallas R. English,Graham G. Giles,Catriona McLean,Gianluca Severi,Diether Lambrechts,T. Vandorpe,Caroline Weltens,Robert Paridaens,Ann Smeets,Patrick Neven,Hans Wildiers,Xianshu Wang,Janet E. Olson,Victoria Cafourek,Zachary S. Fredericksen,Matthew L. Kosel,Celine M. Vachon,Helen Cramp,Daniel Connley,Simon S. Cross,Sabapathy P. Balasubramanian,Malcolm W.R. Reed,Thilo Dörk,Michael Bremer,Andreas Meyer,Johann H. Karstens,Aysun Ay,Tjoung Won Park-Simon,Peter Hillemanns,Jose Ignacio Arias Perez,Primitiva Menéndez Rodríguez,P. Zamora,Javier Benítez,Yon Ko,Hans Fischer,U Hamann,Beate Pesch,Thomas Brüning,Christina Justenhoven,Hiltrud Brauch,Diana Eccles,William J. Tapper,Sue Gerty,Elinor J. Sawyer,Ian Tomlinson,Angela M. Jones,Michael J. Kerin,Nicola Miller,Niall M. McInerney,Hoda Anton-Culver,Argyrios Ziogas,Chen-Yang Shen,Chia-Ni Hsiung,Pei Ei Wu,Show Lin Yang,Jyh Cherng Yu,Shou Tung Chen,Giu Cheng Hsu,Christopher A. Haiman,Brian E. Henderson,Loic Le Marchand,Laurence N. Kolonel,Annika Lindblom,Sara Margolin,Anna Jakubowska,Jan Lubinski,Tomasz Huzarski,Tomasz Byrski,Bohdan Górski,Jacek Gronwald,Maartje J. Hooning,Antoinette Hollestelle,Ans M.W. van den Ouweland,Agnes Jager,Mieke Kriege,Madeleine M.A. Tilanus-Linthorst,Margriet Collée,Shan Wang-Gohrke,Katri Pylkäs,Arja Jukkola-Vuorinen,Kari Mononen,Mervi Grip,Pasi Hirvikoski,Robert Winqvist,Arto Mannermaa,Veli-Matti Kosma,Jaana M. Kauppinen,Vesa Kataja,Päivi Auvinen,Ylermi Soini,Reijo Sironen,Stig E. Bojesen,David Dynnes Ørsted,Diljit Kaur-Knudsen,Henrik Flyger,Børge G. Nordestgaard,Helene Holland,Georgia Chenevix-Trench,Siranoush Manoukian,M. Barile,Paolo Radice,Susan E. Hankinson,David J. Hunter,Rulla M. Tamimi,Suleeporn Sangrajrang,Paul Brennan,James McKay,Fabrice Odefrey,Valerie Gaborieau,Peter Devilee,P. E.A. Huijts,Raem Tollenaar,Caroline Seynaeve,Gillian S. Dite,Carmel Apicella,John L. Hopper,Fleur Hammet,Helen Tsimiklis,Letitia D. Smith,Melissa C. Southey,Manjeet K. Humphreys,Douglas F. Easton,Paul D.P. Pharoah,Mark E. Sherman,Montserrat Garcia-Closas +173 more
TL;DR: It is shown that reproductive factors and BMI are most clearly associated with hormone receptor-positive tumors and suggest that triple-negative or CBP tumors may have distinct etiology.
Journal ArticleDOI
Standard chemotherapy with or without bevacizumab for women with newly diagnosed ovarian cancer (ICON7): overall survival results of a phase 3 randomised trial.
Amit M. Oza,Adrian Cook,Jacobus Pfisterer,Andrew C. Embleton,Jonathan A. Ledermann,Eric Pujade-Lauraine,Gunnar B. Kristensen,Mark S. Carey,Philip Beale,Andrés Cervantes,Tjoung Won Park-Simon,Gordon J. S. Rustin,Florence Joly,Mansoor Raza Mirza,Marie Plante,Michael A. Quinn,Andres Poveda,Gordon C Jayson,Dan Stark,Ann Marie Swart,Laura Farrelly,Richard Kaplan,Mahesh K. B. Parmar,Timothy J. Perren +23 more
TL;DR: The ICON7 trial previously reported improved progression-free survival in women with ovarian cancer with the addition of bevacizumab to standard chemotherapy, with the greatest effect in patients at high risk of disease progression, so evidence of non-proportional hazards was shown.
Journal ArticleDOI
Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants
Nasim Mavaddat,Paul D.P. Pharoah,Kyriaki Michailidou,Jonathan Tyrer,Mark N. Brook,Mark N. Brook,Manjeet K. Bolla,Qin Wang,Joe Dennis,Alison M. Dunning,Mitul Shah,Robert Luben,Judith E. Brown,Stig E. Bojesen,Børge G. Nordestgaard,Sune F. Nielsen,Henrik Flyger,Kamila Czene,Hatef Darabi,Mikael Eriksson,Julian Peto,Isabel dos-Santos-Silva,Frank Dudbridge,Nichola Johnson,Marjanka K. Schmidt,Annegien Broeks,Senno Verhoef,Emiel J. Th. Rutgers,Anthony J. Swerdlow,Alan Ashworth,Nick Orr,Minouk J. Schoemaker,Jonine D. Figueroa,Stephen J. Chanock,Louise A. Brinton,Jolanta Lissowska,Fergus J. Couch,Janet E. Olson,Celine M. Vachon,Vernon S. Pankratz,Diether Lambrechts,Diether Lambrechts,Hans Wildiers,Chantal Van Ongeval,Erik Van Limbergen,Vessela N. Kristensen,Vessela N. Kristensen,Grethe I. Grenaker Alnæs,Silje Nord,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Heli Nevanlinna,Taru A. Muranen,Kristiina Aittomäki,Carl Blomqvist,Jenny Chang-Claude,Anja Rudolph,Petra Seibold,Dieter Flesch-Janys,Peter A. Fasching,Peter A. Fasching,Lothar Haeberle,Arif B. Ekici,Matthias W. Beckmann,Barbara Burwinkel,Barbara Burwinkel,Frederik Marme,Frederik Marme,Andreas Schneeweiss,Andreas Schneeweiss,Christof Sohn,Amy Trentham-Dietz,Polly A. Newcomb,Polly A. Newcomb,Linda Titus,Kathleen M. Egan,David J. Hunter,David J. Hunter,Sara Lindström,Sara Lindström,Rulla M. Tamimi,Peter Kraft,Peter Kraft,Nazneen Rahman,Clare Turnbull,Anthony Renwick,Sheila Seal,Sheila Seal,Jingmei Li,Jianjun Liu,Keith Humphreys,Javier Benitez,Javier Benitez,M. Pilar Zamora,Jose Ignacio Arias Perez,Primitiva Menéndez,Anna Jakubowska,Jan Lubinski,Katarzyna Jaworska-Bieniek,Katarzyna Durda,Natalia Bogdanova,Natalia Bogdanova,Natalia Antonenkova,Thilo Dörk,Hoda Anton-Culver,Susan L. Neuhausen,Argyrios Ziogas,Leslie Bernstein,Peter Devilee,Robert A.E.M. Tollenaar,Caroline M. Seynaeve,Christi J. van Asperen,Angela Cox,Simon S. Cross,Malcolm W.R. Reed,Elza Khusnutdinova,Marina Bermisheva,Marina Bermisheva,Darya Prokofyeva,Zalina Takhirova,Alfons Meindl,Rita K. Schmutzler,Rita K. Schmutzler,Christian Sutter,Rongxi Yang,Rongxi Yang,Peter Schürmann,Michael Bremer,Hans Christiansen,Tjoung Won Park-Simon,Peter Hillemanns,Pascal Guénel,Pascal Guénel,Thérèse Truong,Thérèse Truong,Florence Menegaux,Florence Menegaux,Marie Sanchez,Marie Sanchez,Paolo Radice,Paolo Peterlongo,Siranoush Manoukian,Valeria Pensotti,John L. Hopper,Helen Tsimiklis,Carmel Apicella,Melissa C. Southey,Hiltrud Brauch,Hiltrud Brauch,Hiltrud Brauch,Thomas Brüning,Yon Ko,Yon Ko,Alice J. Sigurdson,Michele M. Doody,Ute Hamann,Diana Torres,Hans Ulrich Ulmer,Asta Försti,Elinor J. Sawyer,Ian Tomlinson,Michael J. Kerin,Nicola Miller,Irene L. Andrulis,Irene L. Andrulis,Julia A. Knight,Gord Glendon,Anna Marie Mulligan,Anna Marie Mulligan,Georgia Chenevix-Trench,Rosemary L. Balleine,Graham G. Giles,Roger L. Milne,Catriona McLean,Annika Lindblom,Sara Margolin,Christopher A. Haiman,Brian E. Henderson,Fredrick R. Schumacher,Loic Le Marchand,Ursula Eilber,Shan Wang-Gohrke,Maartje J. Hooning,Antoinette Hollestelle,Ans M.W. van den Ouweland,Linetta B. Koppert,Jane Carpenter,Christine L. Clarke,Rodney J. Scott,Arto Mannermaa,Vesa Kataja,Veli-Matti Kosma,Jaana M. Hartikainen,Hermann Brenner,Volker Arndt,Christa Stegmaier,Aida Karina Dieffenbach,Robert Winqvist,Katri Pylkäs,Arja Jukkola-Vuorinen,Mervi Grip,Kenneth Offit,Kenneth Offit,Joseph Vijai,Joseph Vijai,Mark E. Robson,Rohini Rau-Murthy,Miriam Dwek,Miriam Dwek,Ruth Swann,Katherine Annie Perkins,Mark S. Goldberg,Mark S. Goldberg,Martine Dumont,Diana Eccles,William J. Tapper,Sajjad Rafiq,Esther M. John,Esther M. John,Alice S. Whittemore,Susan L. Slager,Drakoulis Yannoukakos,Amanda E. Toland,Song Yao,Wei Zheng,Sandra L. Halverson,Anna González-Neira,G Pita,M. Rosario Alonso,Nuria Álvarez,Daniel Herrero,Daniel C. Tessier,Daniel Vincent,Francois Bacot,Craig Luccarini,Caroline Baynes,Shahana Ahmed,Mel Maranian,Catherine S. Healey,Jacques Simard,Per Hall,Douglas F. Easton,Montserrat Garcia-Closas +242 more
TL;DR: The PRS stratifies breast cancer risk in women both with and without a family history of breast cancer, and the observed level of risk discrimination could inform targeted screening and prevention strategies.
Journal ArticleDOI
Refined histopathological predictors of BRCA1 and BRCA2 mutation status: a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia
Amanda B. Spurdle,Fergus J. Couch,Michael T. Parsons,Lesley McGuffog,Daniel Barrowdale,Manjeet K. Bolla,Qin Wang,Sue Healey,Rita K. Schmutzler,Barbara Wappenschmidt,Kerstin Rhiem,Eric Hahnen,Christoph Engel,Alfons Meindl,Nina Ditsch,Norbert Arnold,Hansjoerg Plendl,Dieter Niederacher,Christian Sutter,Shan Wang-Gohrke,Doris Steinemann,Sabine Preisler-Adams,Karin Kast,Raymonda Varon-Mateeva,Steve Ellis,Debra Frost,Radka Platte,Jo Perkins,D. Gareth Evans,Louise Izatt,Ros Eeles,Julian Adlard,Rosemarie Davidson,Trevor Cole,Giulietta Scuvera,Siranoush Manoukian,Bernardo Bonanni,Frederique Mariette,Stefano Fortuzzi,Alessandra Viel,Barbara Pasini,Laura Papi,Liliana Varesco,Rosemary L. Balleine,Katherine L. Nathanson,Susan M. Domchek,Kenneth Offitt,Anna Jakubowska,Noralane M. Lindor,Mads Thomassen,Uffe Birk Jensen,Johanna Rantala,Åke Borg,Irene L. Andrulis,Irene L. Andrulis,Alexander Miron,Thomas Hansen,Trinidad Caldés,Susan L. Neuhausen,Amanda E. Toland,Heli Nevanlinna,Marco Montagna,Judy Garber,Andrew K. Godwin,Ana Osorio,Rachel E. Factor,Mary Beth Terry,Timothy R. Rebbeck,Beth Y. Karlan,Melissa C. Southey,Muhammad Usman Rashid,Nadine Tung,Paul D.P. Pharoah,Fiona M. Blows,Alison M. Dunning,Elena Provenzano,Per Hall,Kamila Czene,Marjanka K. Schmidt,Annegien Broeks,Sten Cornelissen,Senno Verhoef,Peter A. Fasching,Peter A. Fasching,Matthias W. Beckmann,Arif B. Ekici,Dennis J. Slamon,Stig E. Bojesen,Stig E. Bojesen,Børge G. Nordestgaard,Børge G. Nordestgaard,Sune F. Nielsen,Henrik Flyger,Jenny Chang-Claude,Dieter Flesch-Janys,Anja Rudolph,Petra Seibold,Kristiina Aittomäki,Taru A. Muranen,Päivi Heikkilä,Carl Blomqvist,Jonine Figueroa,Stephen J. Chanock,Louise A. Brinton,Jolanta Lissowska,Janet E. Olson,Vernon S. Pankratz,Esther M. John,Esther M. John,Alice S. Whittemore,Dee W. West,Dee W. West,Ute Hamann,Diana Torres,Hans Ulrich Ulmer,Thomas Rüdiger,Peter Devilee,Robert A.E.M. Tollenaar,Caroline Seynaeve,Christi J. van Asperen,Diana Eccles,William J. Tapper,Lorraine Durcan,Louise Jones,Julian Peto,Isabel dos-Santos-Silva,Olivia Fletcher,Nichola Johnson,Miriam Dwek,Ruth Swann,Anita Bane,Anita Bane,Gord Glendon,Anna Marie Mulligan,Anna Marie Mulligan,Graham G. Giles,Graham G. Giles,Roger L. Milne,Roger L. Milne,Laura Baglietto,Laura Baglietto,Catriona McLean,Jane Carpenter,Christine L. Clarke,Rodney J. Scott,Rodney J. Scott,Hiltrud Brauch,Hiltrud Brauch,Thomas Brüning,Yon Ko,Angela Cox,Simon S. Cross,Malcolm W.R. Reed,Jan Lubinski,Katarzyna Jaworska-Bieniek,Katarzyna Durda,Jacek Gronwald,Thilo Dörk,Natalia Bogdanova,Tjoung Won Park-Simon,Peter Hillemanns,Christopher A. Haiman,Brian E. Henderson,Fredrick R. Schumacher,Loic Le Marchand,Barbara Burwinkel,Barbara Burwinkel,Frederik Marmé,Harald Surovy,Harald Surovy,Rongxi Yang,Rongxi Yang,Hoda Anton-Culver,Argyrios Ziogas,Maartje J. Hooning,J. Margriet Collée,John W.M. Martens,Madeleine M. A. Tilanus-Linthorst,Hermann Brenner,Aida Karina Dieffenbach,V. Arndt,Christa Stegmaier,Robert Winqvist,Katri Pylkäs,Arja Jukkola-Vuorinen,Mervi Grip,Annika Lindblom,Sara Margolin,Vijai Joseph,Mark E. Robson,Rohini Rau-Murthy,Anna González-Neira,José Ignacio Arias,Pilar Zamora,Javier Benitez,Arto Mannermaa,Vesa Kataja,Veli-Matti Kosma,Jaana M. Hartikainen,Paolo Peterlongo,Daniela Zaffaroni,Monica Barile,Fabio Capra,Paolo Radice,Soo Hwang Teo,Douglas F. Easton,Antonis C. Antoniou,Georgia Chenevix-Trench,David E. Goldgar +208 more
TL;DR: Large pathology datasets accrued by the Consortium of Investigators of Modifiers of BRCA1/2 and the Breast Cancer Association Consortium are analyzed to reassess histopathological predictors of B RCA1 and BRCa2 mutation status, and robust likelihood ratio estimates for statistical modeling are refined.
Journal ArticleDOI
The role of genetic breast cancer susceptibility variants as prognostic factors
Peter A. Fasching,Paul D.P. Pharoah,Angela Cox,Heli Nevanlinna,Stig E. Bojesen,Thomas Karn,Annegien Broeks,Flora E. van Leeuwen,Laura J. van't Veer,Renate Udo,Alison M. Dunning,Dario Greco,Kristiina Aittomäki,Carl Blomqvist,Mitul Shah,Børge G. Nordestgaard,Henrik Flyger,John L. Hopper,Melissa C. Southey,Carmel Apicella,Montserrat Garcia-Closas,Mark E. Sherman,Jolanta Lissowska,Caroline Seynaeve,Petra E A Huijts,Rob A. E. M. Tollenaar,Argyrios Ziogas,Arif B. Ekici,Claudia Rauh,Arto Mannermaa,Vesa Kataja,Veli-Matti Kosma,Jaana M. Hartikainen,Irene L. Andrulis,Irene L. Andrulis,Hilmi Ozcelik,Anna Marie Mulligan,Gord Glendon,Per Hall,Kamila Czene,Jianjun Liu,Jenny Chang-Claude,Shan Wang-Gohrke,Ursula Eilber,Stefan Nickels,Thilo Dörk,Maria Schiekel,Michael Bremer,Tjoung Won Park-Simon,Graham G. Giles,Graham G. Giles,Gianluca Severi,Gianluca Severi,Laura Baglietto,Laura Baglietto,M.J. Hooning,John W.M. Martens,Agnes Jager,Mieke Kriege,Annika Lindblom,Sara Margolin,Fergus J. Couch,Kristen N. Stevens,Janet E. Olson,Matthew L. Kosel,Simon S. Cross,Sabapathy P. Balasubramanian,Malcolm W.R. Reed,Alexander Miron,Esther M. John,Esther M. John,Robert Winqvist,Katri Pylkäs,Arja Jukkola-Vuorinen,Saila Kauppila,Barbara Burwinkel,Frederik Marmé,Andreas Schneeweiss,Christof Sohn,Georgia Chenevix-Trench,Diether Lambrechts,Anne Sophie Dieudonne,Sigrid Hatse,Erik Van Limbergen,Javier Benitez,Roger L. Milne,M. Pilar Zamora,Jose Ignacio Arias Perez,Bernardo Bonanni,Bernard Peissel,Bernard Loris,Paolo Peterlongo,Preetha Rajaraman,Sara J. Schonfeld,Hoda Anton-Culver,Peter Devilee,Matthias W. Beckmann,Dennis J. Slamon,Kelly-Anne Phillips,Kelly-Anne Phillips,Jonine D. Figueroa,Manjeet K. Humphreys,Douglas F. Easton,Marjanka K. Schmidt +103 more
TL;DR: With the exception of rs3803662 (TOX3), there was no evidence that any of the SNPs associated with BC susceptibility were associated with the BC survival, and survival may be influenced by a distinct set of germline variants from those influencing susceptibility.