Y
Yogi Sundaravadanam
Researcher at Ontario Institute for Cancer Research
Publications - 13
Citations - 1048
Yogi Sundaravadanam is an academic researcher from Ontario Institute for Cancer Research. The author has contributed to research in topics: Genome & Transcriptome. The author has an hindex of 6, co-authored 11 publications receiving 655 citations.
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Journal ArticleDOI
Prediction of acute myeloid leukaemia risk in healthy individuals
Sagi Abelson,Grace Collord,Grace Collord,Stanley W.K. Ng,Omer Weissbrod,Netta Mendelson Cohen,Elisabeth Niemeyer,Noam Barda,Philip C. Zuzarte,Lawrence E. Heisler,Yogi Sundaravadanam,Robert Luben,Shabina Hayat,Ting Ting Wang,Ting Ting Wang,Zhen Zhao,Iulia Cirlan,Trevor J. Pugh,Trevor J. Pugh,Trevor J. Pugh,David Soave,Karen Ng,Calli Latimer,Claire Hardy,Keiran Raine,David T. Jones,Diana Hoult,Abigail Britten,John Douglas Mcpherson,Mattias Johansson,Faridah Mbabaali,Jenna Eagles,Jessica Miller,Danielle Pasternack,Lee Timms,Paul M. Krzyzanowski,Philip Awadalla,Rui Costa,Eran Segal,Scott V. Bratman,Scott V. Bratman,Scott V. Bratman,Philip A. Beer,Sam Behjati,Sam Behjati,Inigo Martincorena,Jean C.Y. Wang,Jean C.Y. Wang,Jean C.Y. Wang,Kristian M. Bowles,Kristian M. Bowles,J. Ramón Quirós,Anna Karakatsani,Carlo La Vecchia,Antonia Trichopoulou,Elena Salamanca-Fernández,José María Huerta,Aurelio Barricarte,Ruth C. Travis,Rosario Tumino,Giovanna Masala,Heiner Boeing,Salvatore Panico,Rudolf Kaaks,Alwin Krämer,Sabina Sieri,Elio Riboli,Paolo Vineis,Matthieu Foll,James McKay,Silvia Polidoro,Núria Sala,Kay-Tee Khaw,Roel Vermeulen,Peter J. Campbell,Peter J. Campbell,Elli Papaemmanuil,Elli Papaemmanuil,Mark D. Minden,Amos Tanay,Ran D. Balicer,Nicholas J. Wareham,Moritz Gerstung,Moritz Gerstung,John E. Dick,John E. Dick,Paul Brennan,George S. Vassiliou,George S. Vassiliou,Liran I. Shlush,Liran I. Shlush +90 more
TL;DR: Deep sequencing is used to analyse genes that are recurrently mutated in AML to distinguish between individuals who have a high risk of developing AML and those with benign ARCH, providing proof-of-concept that it is possible to discriminate ARCH from pre-AML many years before malignant transformation.
Journal ArticleDOI
Childhood cerebellar tumours mirror conserved fetal transcriptional programs
Maria C. Vladoiu,Ibrahim El-Hamamy,Ibrahim El-Hamamy,Laura K. Donovan,Hamza Farooq,Borja L. Holgado,Yogi Sundaravadanam,Vijay Ramaswamy,Liam D. Hendrikse,Sachin Kumar,Stephen C. Mack,John J.Y. Lee,Vernon Fong,Kyle Juraschka,David Przelicki,Antony Michealraj,Patryk Skowron,Betty Luu,Hiromichi Suzuki,A. Sorana Morrissy,Florence M.G. Cavalli,Livia Garzia,Craig Daniels,Xiaochong Wu,Maleeha Qazi,Sheila K. Singh,Jennifer A. Chan,Marco A. Marra,Marco A. Marra,David Malkin,Peter B. Dirks,Lawrence E. Heisler,Trevor J. Pugh,Trevor J. Pugh,Trevor J. Pugh,Karen Ng,Faiyaz Notta,Eric M. Thompson,Claudia L. Kleinman,Claudia L. Kleinman,Alexandra L. Joyner,Nada Jabado,Lincoln Stein,Michael D. Taylor +43 more
TL;DR: Sequencing data from the developing cerebellum are compared with bulk sequencing data from paediatric tumours, providing insights into their potential origins and suggesting that many cerebellar tumours have their origins early in utero.
Journal ArticleDOI
Complex rearrangements and oncogene amplifications revealed by long-read DNA and RNA sequencing of a breast cancer cell line
Maria Nattestad,Sara Goodwin,Karen Ng,Timour Baslan,Fritz J. Sedlazeck,Fritz J. Sedlazeck,Philipp Rescheneder,Tyler Garvin,Han Fang,James Gurtowski,Elizabeth Hutton,Elizabeth Tseng,Chen-Shan Chin,Timothy Beck,Yogi Sundaravadanam,Melissa Kramer,Eric Antoniou,John Douglas Mcpherson,James W. Hicks,W. Richard McCombie,Michael C. Schatz,Michael C. Schatz +21 more
TL;DR: One of the most detailed maps of structural variations in a cancer genome available is developed and a complex sequence of nested duplications and translocations is discovered around the important ERBB2 oncogene, suggesting a punctuated progression.
Journal ArticleDOI
Impact of chemical-induced mutational load increase on immune checkpoint therapy in poorly responsive murine tumors
Elizabeth A. Kuczynski,Janna Krueger,Annabelle Chow,Ping Xu,Shan Man,Yogi Sundaravadanam,Jessica Miller,Paul M. Krzyzanowski,Robert S. Kerbel +8 more
TL;DR: Mutagenized and more immunogenic mouse tumors were not universally sensitized to PD-L1 blockade, and chemically mutagenized variants may be useful to evaluate the impact of immunologically “hot” or “cold” tumors with a high mutational load, to which certain chemotherapy agents may contribute, on immunotherapy outcomes.
Journal ArticleDOI
Epigenomic, genomic, and transcriptomic landscape of schwannomatosis.
Sheila Mansouri,Suganth Suppiah,Yasin Mamatjan,Irene Paganini,Jeff C. Liu,Shirin Karimi,Vikas Patil,Farshad Nassiri,Olivia Singh,Yogi Sundaravadanam,Prisni Rath,Roberta Sestini,Francesca Gensini,Sameer Agnihotri,Jaishri O. Blakeley,Kimberly Laskie Ostrow,David A. Largaespada,Scott R. Plotkin,Anat Stemmer-Rachamimov,Marcela Maria Ferrer,Trevor J. Pugh,Kenneth Aldape,Laura Papi,Gelareh Zadeh,Gelareh Zadeh,Gelareh Zadeh +25 more
TL;DR: Specific genetic, epigenetic, and actionable transcriptional programs associated with painful SWNTS-SWNs including PIGF, VEGF, MEK, and MTOR pathways are identified, which may be harnessed for management of this syndrome.