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Sameer Agnihotri
Researcher at University of Pittsburgh
Publications - 28
Citations - 1560
Sameer Agnihotri is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Glioma & Epigenomics. The author has an hindex of 11, co-authored 28 publications receiving 909 citations. Previous affiliations of Sameer Agnihotri include Boston Children's Hospital & Princess Margaret Cancer Centre.
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Journal ArticleDOI
Intertumoral Heterogeneity within Medulloblastoma Subgroups
Florence M.G. Cavalli,Marc Remke,Marc Remke,Marc Remke,Ladislav Rampášek,John Peacock,David Shih,Betty Luu,Livia Garzia,Jonathon Torchia,Carolina Nor,A. Sorana Morrissy,Sameer Agnihotri,Yuan Yao Thompson,Claudia M. Kuzan-Fischer,Hamza Farooq,Keren Isaev,Keren Isaev,Craig Daniels,Byung Kyu Cho,Seung-Ki Kim,Kyu-Chang Wang,Ji Yeoun Lee,Wiesława Grajkowska,Marta Perek-Polnik,Alexandre Vasiljevic,Cécile Faure-Conter,Anne Jouvet,Caterina Giannini,Amulya A. Nageswara Rao,Kay Ka Wai Li,Ho Keung Ng,Charles G. Eberhart,Ian F. Pollack,Ronald L. Hamilton,G. Yancey Gillespie,James M. Olson,James M. Olson,Sarah Leary,William A. Weiss,Boleslaw Lach,Boleslaw Lach,Lola B. Chambless,Reid C. Thompson,Michael K. Cooper,Rajeev Vibhakar,Peter Hauser,Marie Lise C. van Veelen,Johan M. Kros,Pim J. French,Young Shin Ra,Toshihiro Kumabe,Enrique López-Aguilar,Karel Zitterbart,Jaroslav Sterba,Gaetano Finocchiaro,Maura Massimino,Erwin G. Van Meir,Satoru Osuka,Tomoko Shofuda,Almos Klekner,Massimo Zollo,Jeffrey R. Leonard,Joshua B. Rubin,Nada Jabado,Steffen Albrecht,Steffen Albrecht,Jaume Mora,Timothy E. Van Meter,Shin Jung,Andrew S. Moore,Andrew R. Hallahan,Jennifer A. Chan,Daniela Pretti da Cunha Tirapelli,Carlos Gilberto Carlotti,Maryam Fouladi,José Pimentel,Claudia C. Faria,Ali G. Saad,Luca Massimi,Linda M. Liau,Helen Wheeler,Hideo Nakamura,Samer K. Elbabaa,Mario Perezpeña-Diazconti,Fernando Chico Ponce de León,Shenandoah Robinson,Michal Zapotocky,Alvaro Lassaletta,Annie Huang,Cynthia Hawkins,Uri Tabori,Eric Bouffet,Ute Bartels,Peter B. Dirks,James T. Rutka,Gary D. Bader,Jüri Reimand,Jüri Reimand,Anna Goldenberg,Vijay Ramaswamy,Michael D. Taylor +101 more
TL;DR: Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes.
Journal ArticleDOI
Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas.
Brian Krug,Nicolas De Jay,Nicolas De Jay,Ashot S. Harutyunyan,Shriya Deshmukh,Dylan M. Marchione,Paul Guilhamon,Paul Guilhamon,Paul Guilhamon,Kelsey C. Bertrand,Leonie G. Mikael,Melissa K. McConechy,Carol C.L. Chen,Sima Khazaei,Robert F. Koncar,Sameer Agnihotri,Damien Faury,Benjamin Ellezam,Alexander G. Weil,Josie Ursini-Siegel,Daniel D. De Carvalho,Peter B. Dirks,Peter W. Lewis,Paolo Salomoni,Mathieu Lupien,Mathieu Lupien,Mathieu Lupien,Cheryl H. Arrowsmith,Paul Lasko,Benjamin A. Garcia,Claudia L. Kleinman,Claudia L. Kleinman,Nada Jabado,Stephen C. Mack +33 more
TL;DR: Tumor-derived isogenic models bearing this mutation are generated and it is shown that it leads to pervasive H3K27ac deposition across the genome, which may modulate anti-tumor immune responses as a therapeutic modality for this untreatable disease.
Journal ArticleDOI
The genomic landscape of schwannoma
Sameer Agnihotri,Shahrzad Jalali,Mark R. Wilson,Arnavaz Danesh,Mira Li,George Klironomos,Jonathan R. Krieger,Alireza Mansouri,Osaama H. Khan,Yasin Mamatjan,Natalie Landon-Brace,Takyee Tung,Mark Dowar,Tiantian Li,Jeff Bruce,Kelly Burrell,Peter D. Tonge,Amir Alamsahebpour,Boris Krischek,Pankaj K. Agarwalla,Pankaj K. Agarwalla,Wenya Linda Bi,Wenya Linda Bi,Ian F. Dunn,Rameen Beroukhim,Rameen Beroukhim,Michael G. Fehlings,Vera Bril,Stefano Maria Pagnotta,Stefano Maria Pagnotta,Antonio Iavarone,Trevor J. Pugh,Trevor J. Pugh,Kenneth Aldape,Gelareh Zadeh,Gelareh Zadeh +35 more
TL;DR: Targeting of the MEK-ERK pathway was effective in fusion-positive Schwann cells, suggesting a possible therapeutic approach for this subset of tumors.
Journal ArticleDOI
Targeting pyrimidine synthesis accentuates molecular therapy response in glioblastoma stem cells.
Xiuxing Wang,Kailin Yang,Kailin Yang,Qiulian Wu,Leo J.Y. Kim,Leo J.Y. Kim,Andrew R. Morton,Ryan C. Gimple,Ryan C. Gimple,Briana C. Prager,Briana C. Prager,Briana C. Prager,Yu Shi,Wenchao Zhou,Shruti Bhargava,Zhe Zhu,Li Jiang,Weiwei Tao,Zhixin Qiu,Linjie Zhao,Guoxing Zhang,Xiqing Li,Sameer Agnihotri,Paul S. Mischel,Stephen C. Mack,Shideng Bao,Jeremy N. Rich +26 more
TL;DR: The results demonstrate a therapeutic approach of precision medicine through targeting the nexus between driver mutations and metabolic reprogramming in cancer stem cells and demonstrate sustained inhibition of metabolic activity of pyrimidine synthesis and GSC tumorigenic capacity in vitro.
Journal ArticleDOI
Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma.
Kulandaimanuvel Antony Michealraj,Sachin Kumar,Leo J.Y. Kim,Florence M.G. Cavalli,David Przelicki,John Wojcik,Alberto Delaidelli,Alberto Delaidelli,Andrea Bajic,Olivier Saulnier,Graham MacLeod,Ravi N. Vellanki,Maria C. Vladoiu,Paul Guilhamon,Winnie Ong,John J.Y. Lee,Yanqing Jiang,Borja L. Holgado,Alex Rasnitsyn,Ahmad Malik,Ahmad Malik,Ricky Tsai,Cory Richman,Kyle Juraschka,Joonas Haapasalo,Evan Y. Wang,Pasqualino De Antonellis,Hiromichi Suzuki,Hamza Farooq,Polina Balin,Kaitlin Kharas,Randy Van Ommeren,Olga Sirbu,Avesta Rastan,Stacey L. Krumholtz,Michelle Ly,Moloud Ahmadi,Geneviève Deblois,Dilakshan Srikanthan,Betty Luu,James Loukides,Xiaochong Wu,Livia Garzia,Vijay Ramaswamy,Evgeny Kanshin,María Sánchez-Osuna,Ibrahim El-Hamamy,Ibrahim El-Hamamy,Fiona J. Coutinho,Panagiotis Prinos,Sheila K. Singh,Laura K. Donovan,Craig Daniels,Daniel Schramek,Daniel Schramek,Mike Tyers,Samuel Weiss,Lincoln Stein,Lincoln Stein,Mathieu Lupien,Bradly G. Wouters,Benjamin A. Garcia,Cheryl H. Arrowsmith,Cheryl H. Arrowsmith,Cheryl H. Arrowsmith,Poul H. Sorensen,Poul H. Sorensen,Stephane Angers,Nada Jabado,Peter B. Dirks,Stephen C. Mack,Sameer Agnihotri,Jeremy N. Rich,Michael D. Taylor +73 more
TL;DR: It is demonstrated that PFA ependymomas are maintained under hypoxia, associated with restricted availability of specific metabolites to diminish histone methylation, and increase histone demethylation and acetylation at histone 3 lysine 27 (H3K27).