F
Fabian Hia
Researcher at Kyoto University
Publications - 8
Citations - 184
Fabian Hia is an academic researcher from Kyoto University. The author has contributed to research in topics: Messenger RNA & Codon usage bias. The author has an hindex of 4, co-authored 8 publications receiving 107 citations.
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Journal ArticleDOI
Codon bias confers stability to human mRNAs
Fabian Hia,Sheng Fan Yang,Yuichi Shichino,Masanori Yoshinaga,Yasuhiro Murakawa,Alexis Vandenbon,Akira Fukao,Toshinobu Fujiwara,Markus Landthaler,Markus Landthaler,Tohru Natsume,Shungo Adachi,Shintaro Iwasaki,Osamu Takeuchi +13 more
TL;DR: ILF2 and ILF3 are identified as RNA‐binding proteins that differentially regulate global mRNA abundances based on codon bias and it is demonstrated thatCodon bias is a two‐pronged system that governs mRNA abundance.
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Regnase-1 and Roquin Nonredundantly Regulate Th1 Differentiation Causing Cardiac Inflammation and Fibrosis.
Xiaotong Cui,Takashi Mino,Masanori Yoshinaga,Yoshinari Nakatsuka,Fabian Hia,Daichi Yamasoba,Tohru Tsujimura,Keizo Tomonaga,Yutaka Suzuki,Takuya Uehata,Osamu Takeuchi +10 more
TL;DR: Results demonstrate that Regnase-1 and Roquin maintain T cell immune homeostasis and regulate Th1 polarization synergistically and contribute to the synergistic control of T cell activation/polarization.
Journal ArticleDOI
Translation-dependent unwinding of stem–loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs
Takashi Mino,Noriki Iwai,Masayuki Endo,Kentaro Inoue,Kotaro Akaki,Fabian Hia,Takuya Uehata,Tomoko Emura,Kumi Hidaka,Yutaka Suzuki,Daron M. Standley,Mariko Okada-Hatakeyama,Shigeo Ohno,Hiroshi Sugiyama,Akio Yamashita,Osamu Takeuchi +15 more
TL;DR: Small-molecule inhibition of SMG1 prevents RNA unwinding in dendritic cells, allowing post-transcriptional control of innate immune responses, and is critical for rapid resolution of inflammation through restriction of the number of proteins translated by a given mRNA.
Journal ArticleDOI
The effects of codon bias and optimality on mRNA and protein regulation
Fabian Hia,Osamu Takeuchi +1 more
TL;DR: The effects of codon bias with regard to codon optimality in several biological processes centred on translation, such as mRNA stability and protein folding among others are addressed.
Journal ArticleDOI
IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay.
Kotaro Akaki,Kosuke Ogata,Yuhei Yamauchi,Noriki Iwai,Ka Man Tse,Fabian Hia,Atsushi Mochizuki,Yasushi Ishihama,Takashi Mino,Osamu Takeuchi +9 more
TL;DR: In this article, the Regnase-1-14-3-3 interaction was found to be mediated by IRAK1 through a previously uncharacterized C-terminal structural domain.