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Ying-Wooi Wan
Researcher at Boston Children's Hospital
Publications - 40
Citations - 2005
Ying-Wooi Wan is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Rett syndrome & MECP2. The author has an hindex of 20, co-authored 40 publications receiving 1255 citations. Previous affiliations of Ying-Wooi Wan include Baylor College of Medicine.
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Journal ArticleDOI
Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease
Ethan R. Roy,Baiping Wang,Ying-Wooi Wan,Gabriel Chiu,Allysa L. Cole,Zhuoran Yin,Nicholas E. Propson,Yin Xu,Joanna L. Jankowsky,Zhandong Liu,Virginia M.-Y. Lee,John Q. Trojanowski,Stephen D. Ginsberg,Oleg Butovsky,Hui Zheng,Wei Cao +15 more
TL;DR: Gene expression interrogation revealed that IFN pathway was grossly upregulated in clinical AD and significantly correlated with disease severity and complement activation, therefore, IFN constitutes a pivotal element within the neuroinflammatory network of AD and critically contributes to neuropathogenic processes.
Journal ArticleDOI
Digital sorting of complex tissues for cell type-specific gene expression profiles
TL;DR: A Digital Sorting Algorithm for extracting cell-type specific gene expression profiles from mixed tissue samples that is unbiased and does not require prior knowledge of cell type frequencies is described.
Journal ArticleDOI
Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models.
Ying-Wooi Wan,Ying-Wooi Wan,Rami Al-Ouran,Rami Al-Ouran,Carl Grant Mangleburg,Carl Grant Mangleburg,Thanneer M. Perumal,Tom V. Lee,Tom V. Lee,Katherine Allison,Katherine Allison,Vivek Swarup,Cory C. Funk,Chris Gaiteri,Mariet Allen,Minghui Wang,Sarah M. Neuner,Catherine C. Kaczorowski,Vivek M. Philip,Gareth R. Howell,Heidi Martini-Stoica,Hui Zheng,Hongkang Mei,Xiaoyan Zhong,Jungwoo Wren Kim,Valina L. Dawson,Ted M. Dawson,Ping-Chieh Pao,Ping-Chieh Pao,Li-Huei Tsai,Li-Huei Tsai,Jean-Vianney Haure-Mirande,Michelle E. Ehrlich,Paramita Chakrabarty,Yona Levites,Xue Wang,Eric B. Dammer,Gyan Srivastava,Sumit Mukherjee,Solveig K. Sieberts,Larsson Omberg,Kristen D. Dang,James A. Eddy,Phil Snyder,Yooree Chae,Sandeep Amberkar,Sandeep Amberkar,Wenbin Wei,Wenbin Wei,Winston Hide,Winston Hide,Christoph Preuss,Ayla Ergun,Phillip J. Ebert,David C. Airey,Sara Mostafavi,Lei Yu,Hans-Ulrich Klein,Hans-Ulrich Klein,Gregory W. Carter,David A. Collier,Todd E. Golde,Allan I. Levey,David A. Bennett,Karol Estrada,T. Matthew Townsend,Bin Zhang,Eric E. Schadt,Philip L. De Jager,Philip L. De Jager,Nathan D. Price,Nilufer Ertekin-Taner,Zhandong Liu,Zhandong Liu,Joshua M. Shulman,Lara M. Mangravite,Benjamin A. Logsdon +76 more
TL;DR: A consensus atlas of the human brain transcriptome in Alzheimer’s disease (AD), based on meta-analysis of differential gene expression in 2,114 postmortem samples, is presented, highlighting transcriptional networks altered by human brain pathophysiology and identifying correspondences with mouse models for AD preclinical studies.
Journal ArticleDOI
MARRVEL: Integration of Human and Model Organism Genetic Resources to Facilitate Functional Annotation of the Human Genome.
Julia Wang,Rami Al-Ouran,Yanhui Hu,Seon Young Kim,Ying-Wooi Wan,Michael F. Wangler,Shinya Yamamoto,Shinya Yamamoto,Hsiao-Tuan Chao,Aram Comjean,Stephanie E. Mohr,Christopher J. Adams,David R. Adams,Mercedes E. Alejandro,Patrick Allard,Euan A. Ashley,Mashid S. Azamian,Carlos A. Bacino,Ashok Balasubramanyam,Hayk Barseghyan,Alan H. Beggs,Hugo J. Bellen,Jonathan A. Bernstein,Anna Bican,David P. Bick,Camille L. Birch,Braden E. Boone,Lauren C. Briere,Donna M. Brown,Matthew H. Brush,Elizabeth A. Burke,Lindsay C. Burrage,Katherine R. Chao,Gary D. Clark,Joy D. Cogan,Cynthia M. Cooper,William J. Craigen,Mariska Davids,Jyoti G. Dayal,Esteban C. Dell'Angelica,Shweta U. Dhar,Katrina M. Dipple,Laurel A. Donnell-Fink,Naghmeh Dorrani,Daniel C. Dorset,David D. Draper,Annika M. Dries,David J. Eckstein,Lisa Emrick,Christine M. Eng,Cecilia Esteves,Tyra Estwick,Paul G. Fisher,Trevor S. Frisby,Kate Frost,William A. Gahl,Valerie Gartner,Rena A. Godfrey,Mitchell Goheen,Gretchen Golas,David Goldstein,Mary “Gracie” G. Gordon,Sarah E. Gould,Jean-Philippe F. Gourdine,Brett H. Graham,Catherine Groden,Andrea L. Gropman,Mary E. Hackbarth,Melissa A. Haendel,Rizwan Hamid,Neil A. Hanchard,Lori H. Handley,Isabel Hardee,Matthew R. Herzog,Ingrid A. Holm,Ellen M. Howerton,Howard J. Jacob,Mahim Jain,Yong-hui Jiang,Jean M. Johnston,Angela Jones,Alanna E. Koehler,David M. Koeller,Isaac S. Kohane,Jennefer N. Kohler,Donna M. Krasnewich,Elizabeth L. Krieg,Joel B. Krier,Jennifer E. Kyle,Seema R. Lalani,Lea Latham,Yvonne L. Latour,C. Christopher Lau,Jozef Lazar,Brendan Lee,Hane Lee,Paul R. Lee,Shawn Levy,Denise J. Levy,Richard A. Lewis,Adam P. Liebendorfer,Sharyn A. Lincoln,Carson R. Loomis,Joseph Loscalzo,Richard L. Maas,Ellen Macnamara,Calum A. MacRae,Valerie Maduro,May Christine V. Malicdan,Laura A. Mamounas,Teri A. Manolio,Thomas C. Markello,Paul Mazur,Alexandra J. McCarty,Allyn McConkie-Rosell,Alexa T. McCray,Thomas O. Metz,Matthew Might,Paolo Moretti,John J.E. Mulvihill,Jennifer L. Murphy,Donna M. Muzny,Michele Nehrebecky,Stan F. Nelson,J. Scott Newberry,John H. Newman,Sarah K. Nicholas,Donna Novacic,Jordan S. Orange,J. Carl Pallais,Christina G.S. Palmer,Jeanette C. Papp,Loren D.M. Pena,John A. Phillips,Jennifer E. Posey,John H. Postlethwait,Lorraine Potocki,Barbara N. Pusey,Rachel B. Ramoni,Amy K. Robertson,Lance H. Rodan,Jill A. Rosenfeld,Sarah Sadozai,Katherine E. Schaffer,Kelly Schoch,Molly C. Schroeder,Daryl A. Scott,Prashant Sharma,Vandana Shashi,Edwin K. Silverman,Janet S. Sinsheimer,Ariane Soldatos,Rebecca C. Spillmann,Kimberly Splinter,Joan M. Stoler,Nicholas Stong,Kimberly A. Strong,Jennifer A. Sullivan,David A. Sweetser,Sara P. Thomas,Cynthia J. Tifft,Nathanial J. Tolman,Camilo Toro,Alyssa A. Tran,Zaheer M. Valivullah,Eric Vilain,Daryl Waggott,Colleen E. Wahl,Nicole M. Walley,Christopher A. Walsh,Mike Warburton,Patricia A. Ward,Katrina M. Waters,Bobbie-Jo M. Webb-Robertson,Alec A. Weech,Monte Westerfield,Matthew T. Wheeler,Anastasia L. Wise,Lynne A. Wolfe,Elizabeth A. Worthey,Yaping Yang,Guoyun Yu,Patricia A. Zornio,Norbert Perrimon,Norbert Perrimon,Zhandong Liu +185 more
TL;DR: MARRVEL dramatically improves efficiency and accessibility to data collection and facilitates analysis of human genes and variants by cross-disciplinary integration of 18 million records available in public databases to facilitate clinical diagnosis and basic research.
Journal ArticleDOI
Reversal of phenotypes in MECP2 duplication mice using genetic rescue or antisense oligonucleotides
Yehezkel Sztainberg,Hongmei Chen,John W. Swann,John W. Swann,Shuang Hao,Bin Tang,Bin Tang,Zhenyu Wu,Zhenyu Wu,Jianrong Tang,Jianrong Tang,Ying-Wooi Wan,Ying-Wooi Wan,Zhandong Liu,Zhandong Liu,Frank Rigo,Huda Y. Zoghbi +16 more
TL;DR: In this paper, a conditional MECP2-overexpressing mouse model was used to study the effect of methyl-CpG-binding protein 2 (MeCP2) overexpression.