Hyun Soo Kim

TL;DR: The interim integrative analysis of DNA copy number, gene expression and DNA methylation aberrations in 206 glioblastomas reveals a link between MGMT promoter methylation and a hypermutator phenotype consequent to mismatch repair deficiency in treated gliobeasts, demonstrating that it can rapidly expand knowledge of the molecular basis of cancer.

TL;DR: The findings demonstrate a surprisingly high rate of hyper- and hypomethylation as a function of age in normal mouse small intestine tissues and a strong tissue-specificity to the process, which concludes that epigenetic deregulation is a common feature of aging in mammals.

TL;DR: In colorectal cancer (CRC), DNA methylation anomalies define distinct subgroups termed CpG island methylator phenotype 1 (CIMP1), CIMp2, and CIMP‐negative, and the role of this classification in predicting recurrence and disease‐free survival (DFS) in resected stage III CRC was evaluated.

TL;DR: Findings suggest MINT25 is a sensitive and specific marker for screening in gastric cancer, and a new method for Gastric cancer detection by DNA methylation in Gastric washes is developed.

TL;DR: In this paper, the authors exhaustively analyzed copy number alterations in 1,451 PDX and matched patient tumor (PT) samples from 509 PDX models, and they showed strong CNA conservation from PTs through late-passage PDXs.