Academy of Sciences of the Czech Republic

About: Academy of Sciences of the Czech Republic is a government organization based out in Prague, Czechia. It is known for research contribution in the topics: Population & Catalysis. The organization has 27866 authors who have published 71021 publications receiving 1821686 citations.

High and rising economic costs of biological invasions worldwide

Abstract: Biological invasions are responsible for substantial biodiversity declines as well as high economic losses to society and monetary expenditures associated with the management of these invasions1,2 The InvaCost database has enabled the generation of a reliable, comprehensive, standardized and easily updatable synthesis of the monetary costs of biological invasions worldwide3 Here we found that the total reported costs of invasions reached a minimum of US$1288 trillion (2017 US dollars) over the past few decades (1970-2017), with an annual mean cost of US$268 billion Moreover, we estimate that the annual mean cost could reach US$1627 billion in 2017 These costs remain strongly underestimated and do not show any sign of slowing down, exhibiting a consistent threefold increase per decade We show that the documented costs are widely distributed and have strong gaps at regional and taxonomic scales, with damage costs being an order of magnitude higher than management expenditures Research approaches that document the costs of biological invasions need to be further improved Nonetheless, our findings call for the implementation of consistent management actions and international policy agreements that aim to reduce the burden of invasive alien species

Ultralow Fouling and Functionalizable Surface Chemistry Based on a Zwitterionic Polymer Enabling Sensitive and Specific Protein Detection in Undiluted Blood Plasma

Abstract: A crucial step in the development of implanted medical devices, in vivo diagnostics, and microarrays is the effective prevention of nonspecific protein adsorption from real-world complex media such as blood plasma or serum. In this work, a zwitterionic poly(carboxybetaine acrylamide) (polyCBAA) biomimetic material was employed to create a unique biorecognition coating with an ultralow fouling background, enabling the sensitive and specific detection of proteins in blood plasma. Conditions for surface activation, protein immobilization, and surface deactivation of the carboxylate groups in the polyCBAA coating were determined. An antibody-functionalized polyCBAA surface platform was used to detect a target protein in blood plasma using a sensitive surface plasmon resonance (SPR) sensor. A selective protein was directly detected from 100% human blood plasma with extraordinary specificity and sensitivity. The total nonspecific protein adsorption on the functionalized polyCBAA surface was very low (<3 ng/cm2 ...

Behavior protocols for software components

Abstract: In this paper, we propose a means to enhance an architecture description language with a description of component behavior. A notation used for this purpose should be able to express the "interplay" on the component's interfaces and reflect step-by-step refinement of the component's specification during its design. In addition, the notation should be easy to comprehend and allow for formal reasoning about the correctness of the specification refinement and also about the correctness of an implementation in terms of whether it adheres to the specification. Targeting all these requirements together, the paper proposes employing behavior protocols which are based on a notation similar to regular expressions. As proof of the concept, the behavior protocols are used in the SOFA architecture description language at three levels: interface, frame, and architecture. Key achievements of this paper include the definitions of bounded component behavior and protocol conformance relation. Using these concepts, the designer can verify the adherence of a component's implementation to its specification at runtime, while the correctness of refining the specification can be verified at design time.

Silybin and silymarin - new effects and applications

Abstract: This article aims to review critically literature published mainly within this millennium on the new and emerging applications of silymarin, the polyphenolic fraction from the seeds of Silybum marianum and its main component silybin. Silymarin and silybin used so far mostly as hepatoprotectants were shown to have other interesting activities as e.g., anticancer and canceroprotective. These activities were demonstrated in a large variety of illnesses of different organs as e.g., prostate, lungs, CNS, kidneys, pancreas and others. Besides the cytoprotective activity of silybin mediated by its antioxidative and radical-scavenging properties also new activities based on the specific receptor interaction were discovered--e.g., inhibition and modulation of drug transporters, P-glycoproteins, estrogenic receptors, nuclear receptors and some others. New derivatives of silybin open new ways to its therapeutic applications. Pharmacology dealing with optically pure silybin diastereomers may suggest new mechanisms of its action.

Structure-Function of CD36 and Importance of Fatty Acid Signal Transduction in Fat Metabolism

Abstract: CD36 (cluster of differentiation 36) is a scavenger receptor that functions in high-affinity tissue uptake of long-chain fatty acids (FAs) and contributes under excessive fat supply to lipid accumulation and metabolic dysfunction. This review describes recent evidence regarding the CD36 FA binding site and a potential mechanism for FA transfer. It also presents the view that CD36 and FA signaling coordinate fat utilization, a view that is based on newly identified CD36 actions that involve oral fat perception, intestinal fat absorption, secretion of the peptides cholecystokinin and secretin, regulation of hepatic lipoprotein output, activation of beta oxidation by muscle, and regulation of the production of the FA-derived bioactive eicosanoids. Thus abnormalities of fat metabolism and the associated pathology might involve dysfunction of CD36-mediated signal transduction in addition to the changes in FA uptake.