Institution
Australian Catholic University
Education•Brisbane, Queensland, Australia•
About: Australian Catholic University is a education organization based out in Brisbane, Queensland, Australia. It is known for research contribution in the topics: Population & Poison control. The organization has 2721 authors who have published 10013 publications receiving 215248 citations. The organization is also known as: ACU & ACU National.
Papers published on a yearly basis
Papers
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TL;DR: This work proposes a novel approach to the classification and analysis of sedentary behaviors, which differentiates between those that are passive and mentally active, and research questions relating to measurement, causal relationships and mechanisms are considered.
Abstract: Detrimental associations of sedentary behaviors with depression have been identified, but findings are inconsistent. We propose a novel approach to the classification and analysis of sedentary behaviors, which differentiates between those that are passive (e.g., television viewing) and mentally active (e.g., reading). Available evidence is summarized, and research questions relating to measurement, causal relationships, and mechanisms are considered.
80 citations
03 Jan 2013
TL;DR: In this article, the authors assess knowledge about dementia across a range of health care staff in a regional health service district in Queensland, Australia, using the validated 30-item Alzheimer's Disease Knowledge Scale (ADKS).
Abstract: Background
Continued aging of the population is expected to be accompanied by substantial increases in the number of people with dementia and in the number of health care staff required to care for them. Adequate knowledge about dementia among health care staff is important to the quality of care delivered to this vulnerable population. The purpose of this study was to assess knowledge about dementia across a range of health care staff in a regional health service district.
Methods
Knowledge levels were investigated via the validated 30-item Alzheimer's Disease Knowledge Scale (ADKS). All health service district staff with e-mail access were invited to participate in an online survey. Knowledge levels were compared across demographic categories, professional groups, and by whether the respondent had any professional or personal experience caring for someone with dementia. The effect of dementia-specific training or education on knowledge level was also evaluated.
Results
A diverse staff group (N = 360), in terms of age, professional group (nursing, medicine, allied health, support staff) and work setting from a regional health service in Queensland, Australia responded. Overall knowledge about Alzheimer's disease was of a generally moderate level with significant differences being observed by professional group and whether the respondent had any professional or personal experience caring for someone with dementia. Knowledge was lower for some of the specific content domains of the ADKS, especially those that were more medically-oriented, such as 'risk factors' and 'course of the disease.' Knowledge was higher for those who had experienced dementia-specific training, such as attendance at a series of relevant workshops.
Conclusions
Specific deficits in dementia knowledge were identified among Australian health care staff, and the results suggest dementia-specific training might improve knowledge. As one piece of an overall plan to improve health care delivery to people with dementia, this research supports the role of introducing systematic dementia-specific education or training.
80 citations
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TL;DR: Acceptance- and mindfulness-based approaches appear to be effective and safe interventions for individuals with schizophrenia spectrum disorders and could be a useful extension of standard casemanagement and psychofarmacology.
80 citations
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TL;DR: It is demonstrated that dMRI analyses can benefit from dimensionality reduction techniques, to help disentangling the neurobiological underpinnings of white matter organisation.
80 citations
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20 Jan 2020
TL;DR: Rec reciprocal regulation is established between the two key nutrient sensors in cells, m TORC1 and AMPK, showing that mTORC1 directly inhibits AMPK by phosphorylation at S345 in the AMPK catalytic subunit α2.
Abstract: Central to cellular metabolism and cell proliferation are highly conserved signalling pathways controlled by mammalian target of rapamycin (mTOR) and AMP-activated protein kinase (AMPK)1,2, dysregulation of which are implicated in pathogenesis of major human diseases such as cancer and type 2 diabetes. AMPK pathways leading to reduced cell proliferation are well established and, in part, act through inhibition of TOR complex-1 (TORC1) activity. Here we demonstrate reciprocal regulation, specifically that TORC1 directly down-regulates AMPK signalling by phosphorylating the evolutionarily conserved residue Ser367 in the fission yeast AMPK catalytic subunit Ssp2, and AMPK α1Ser347/α2Ser345 in the mammalian homologs, which is associated with reduced phosphorylation of activation loop Thr172. Genetic or pharmacological inhibition of TORC1 signalling led to AMPK activation in the absence of increased AMP:ATP ratios; under nutrient stress conditions this was associated with growth limitation in both yeast and human cell cultures. Our findings reveal fundamental, bi-directional regulation between two major metabolic signalling networks and uncover new opportunity for cancer treatment strategies aimed at suppressing cell proliferation in the nutrient-poor tumor microenvironment.
80 citations
Authors
Showing all 2824 results
Name | H-index | Papers | Citations |
---|---|---|---|
John J.V. McMurray | 178 | 1389 | 184502 |
James F. Sallis | 169 | 825 | 144836 |
Richard M. Ryan | 164 | 405 | 244550 |
Herbert W. Marsh | 152 | 646 | 89512 |
Jacquelynne S. Eccles | 136 | 378 | 84036 |
John A. Kanis | 133 | 625 | 96992 |
Edward L. Deci | 130 | 284 | 206930 |
Thomas J. Ryan | 116 | 675 | 67462 |
Bruce E. Kemp | 110 | 423 | 45441 |
Mark J. Nieuwenhuijsen | 107 | 647 | 49080 |
Peter Rosenbaum | 103 | 446 | 45732 |
Barbara Riegel | 101 | 507 | 77674 |
Ego Seeman | 101 | 529 | 46392 |
Paul J. Frick | 100 | 306 | 33579 |
Robert J. Vallerand | 98 | 301 | 41840 |