Institution
Belarusian State Medical University
Education•Minsk, Belarus•
About: Belarusian State Medical University is a education organization based out in Minsk, Belarus. It is known for research contribution in the topics: Population & Medicine. The organization has 536 authors who have published 513 publications receiving 4635 citations.
Topics: Population, Medicine, Gene, Optical flow, Alpha helix
Papers published on a yearly basis
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28 Mar 2017••
01 Sep 2017••
08 Dec 2017TL;DR: Dyslipidemia is widespread in children on RRT and reduction of the glomerular filtration rate in children after kidney transplantation is accompanied by an increase in TG levels, which can prevent the development of severe lipid imbalance which persists of dialysis treatment.
Abstract: Cardiovascular complications are the main problems associated with end stage renal disease (ESRD) in adult, which began renal replacement therapy (RRT) in childhood. One of the factors contributing to this can be an imbalance of blood lipids.
Aim of the study was to evaluate changes in the lipid profile in children with ESRD, depending on the RRT method and age, and also after kidney transplantation depending on the glomerular filtration rate.
Materials and methods. In 91 children with ESRD at the age of 2–17 years who received peritoneal dialysis (PD) or hemodialysis (HD), or after kidney transplantation (Tx), total cholesterol (CH), triglycerides (TG), lipoproteins high density (HDL) ) were measured in 663 samples of blood and calculated fraction of non–HDL (CH – HDL). Dyslipidemia was defined as TG>1,13 mmol/1 (0–9years) and >1,47mmol/l (10–17years), CH> 5,18mmol/l, non–HDL >3,7mmol/l, HDL <1.0 mmol/l.
Results. The prevalence of dyslipidemia in children was 90,4% on PD, 65,2% on HD and 32,6% after Tx, mainly due to hypertriglyceridemia in 80,8% on PD, 65,2% on HD and 20,8% after Tx. The levels ofTG and non–HDL were also significantly higher in PD and HD patients than after Tx. Children of the younger age group (2–5 years) on PD had the worst lipid profile. After kidney transplantation a significant reduction of TG and cholesterol was detected in PD patients and only TG in HD patients. Reduction of the glomerular filtration rate in children after kidney transplantation is accompanied by an increase in TG levels.
Conclusion. Dyslipidemia is widespread in children on RRT. Preemptive kidney transplantation can prevent the development of severe lipid imbalance which persists of dialysis treatment.
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TL;DR: Evidence that even rare episodic alcohol consumption by young people is not harmless is presented, reflected in the reduced attention concentration and lower academic buoyancy compared to those who completely abstain from alcohol.
Abstract: This paper presents evidence that even rare episodic alcohol consumption by young people is not harmless. Unsafe rare episodic alcohol consumption by youths (students) was reflected in the reduced attention concentration and lower academic buoyancy, compared to those who completely abstain from alcohol. Key Words: Alcohol, youth, students, attention concentration, academic buoyancy
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TL;DR: Utility of newly developed modelling based on hemodynamic BP indexes in the prediction of BP alterations secondary to CPAP in OSA hypertensive patients is suggested.
Abstract: Background. The goal of our study was to define the hemodynamic phenotypes in hypertensive patients with newly diagnosed obstructive sleep apnoea (OSA) using the individual modelling of hemodynamics derived from ambulatory blood pressure monitoring (ABPM), a method proposed by our group previously, and to assess its validity in blood pressure alterations secondary to continuous positive airway pressure (CPAP). Material and methods. Thirty-three hypertensive patients with moderate-to-severe OSA were investigated. All patients underwent ABPM on two occasions: at baseline and after one week CPAP. The sets of BP indexes at first ABPM were used for individual modelling to define the hemodynamic phenotype (class) based on regression analyses; specifically, the phenotypes were defined for daytime, nighttime and for 24 hours. The CPAP therapy efficacy was predefined as improvement in BP nighttime decrease for additional 5% as compared to baseline ABPM. With reference to this criterion, patients were further classified as responders (who achieved this target), and non-responders. Results. Only 21.2% of hypertensive patients with OSA had optimal hemodynamic phenotype (class H2), despite comprehensive antihypertensive therapy; most of the other patients were classified either as harmonic type (class H3; 39.4%), or of diastolic dysfunctional type (class D3; 15.2%). In the daytime period 18.2% of patients with OSA were classified as D1-class, which is associated with high risk of acute hypotensive episodes. Responders were more frequently characterized by phenotype H3 (daytime) vs. nonresponders: 53.3% and 5.6% respectively; P < 0.05. At nighttime non-responders were more likely to transform the different baseline classes into H3 and D2; P < 0.05 vs. responders. Conclusion. Our study suggest utility of newly developed modelling based on hemodynamic BP indexes in the prediction of BP alterations secondary to CPAP in OSA hypertensive patients.
Authors
Showing all 543 results
Name | H-index | Papers | Citations |
---|---|---|---|
Hassib Narchi | 21 | 148 | 2027 |
Yuri E. Demidchik | 18 | 37 | 1117 |
Artur Mezheyeuski | 14 | 53 | 834 |
Igor Karpov | 13 | 40 | 539 |
Vladislav Victorovich Khrustalev | 11 | 51 | 349 |
Ilona Nekhayeva | 10 | 10 | 545 |
Eugene Victorovich Barkovsky | 10 | 24 | 207 |
Menizibeya O. Welcome | 9 | 46 | 394 |
Anna Vassilenko | 9 | 21 | 374 |
Aliaksandr Skrahin | 9 | 17 | 300 |
Ilya V. Pyko | 8 | 9 | 545 |
Oleg Skugarevsky | 6 | 12 | 1004 |
Anna Portyanko | 6 | 12 | 163 |
Vladimir A. Pereverzev | 5 | 16 | 75 |
Vladimir Kirillov | 5 | 9 | 60 |