Belarusian State Medical University

About: Belarusian State Medical University is a education organization based out in Minsk, Belarus. It is known for research contribution in the topics: Population & Medicine. The organization has 536 authors who have published 513 publications receiving 4635 citations.

A new health care index predicts short term mortality for TB and HIV co-infected people.

Abstract: BACKGROUND: Using 2004-2007 TB:HIV Study data from Europe and Latin America, we previously generated a health care index (HCI) for TB and HIV co-infected people. With improvements in diagnostic and management practices, we have now updated the HCI with new data.METHODS: We evaluated nine aspects of health care in Cox proportional hazards models on time from TB diagnosis to death. Kaplan-Meier methods were used to estimate the probability of death by HCI quartile.RESULTS: Of 1396 eligible individuals (72% male, 59% from Eastern Europe), 269 died within 12 months. Use of rifamycin/isoniazid/pyrazinamide-based treatment (HR 0.67, 95% CI 0.50-0.89), TB drug susceptibility testing (DST) and number of active TB drugs (DST + . Lower HCI was associated with an increased probability of death; 30% (95% CI 26-35) vs. 9% (95% CI 6-13) in the lowest vs. the highest quartile. CONCLUSION: We found five potentially modifiable health care components that were associated with mortality among TB-HIV positive individuals. Validation of our HCI in other TB cohorts could enhance our findings.

Biomechanical Effects of Maxillary Expansion in Cross-Bite Patients During Orthodontic Treatment with Hyrax Screw

Abstract: The aim of this study was finite element analysis of stress-strain state of the human maxillary complex with and without cleft palate Loading the skull is carried out by activating orthodontic device HYRAX Model of the skull and supporting teeth of upper jaw obtained on the basis of tomographic data for dry intact skull of an adult Design of orthodontic device differ position of screws and rods relative to the palate Equivalent stresses in the bones of the craniofacial complex are assessed It is shown that large stresses occur in the maxillary complex, if the screw and rods of orthodontic devices are located in a horizontal plane for skull with and without cleft Also in the intact skull big stresses appear in the bone of the upper jaw with location of the screw and rods of orthodontic device in a horizontal plane In the rest of the skull bones stresses are insignificant By moving the device screw to the palate the values of maximum stresses are reduced, but the region of big stresses displaced to the pterygoid plate and pharyngeal tubercle In the skull with cleft for different positions of screws and rods orthodontic device the upper jaw is loaded fragmentary High stresses are observed in the region of the maxilla near the zygomatic arches and along the edges of eye-sockets When placing screw of orthodontic device close to palate the stresses decreases, but are observed in most part of the zygomatic arches

HERC2 and OCA2 genes polimorphisms in relation to the iris color variation of the Belarusian population

Abstract: The human genetic phenotyping is one of the most intensely developing area of forensic genetics. Externally visible traits, including eye color, can be predicted by analyzing single nucleotide polymorphisms with a high predictive rate. We studied the polymorphisms rs12913832 and rs1800407 in the HERC2 and OCA2 genes, respectively, to evaluate its prognostic availability in relation to the iris pigmentation of the Belarusian population. For this, both eye images and DNA samples were collected from 314 individuals to analyze the key polymorphisms by the TaqMan assay. Our data confirmed a relevance of rs12913832:A>G and rs1800407:G>A in the prediction context. The highest values of the sensitivity (SE = 0.94) and the specificity (SP = 0.90) were obtained for rs12913832, demonstrating the high efficiency of this marker as a classifier of phenotypic groups. The presence of the ancestral dominant allele rs12913832-A causes a dark (brown) iris pigmentation, how- ever, the heterozygous state rs12913832:GA includes a range of mixed variants. The predictive value of rs1800407 for the genetic phenotyping is highly significant (SE = 0.98), but has a low specificity (SP = 0.14), thus rs1800407, not being an effective classifier, can be used as an auxiliary in the eye color predictive model. The analysis of a cumulative impact of the both poly- morphisms on the iris color variation shows their high prospects for the genetic phenotyping of the Belarusian population.