Belarusian State Medical University

About: Belarusian State Medical University is a education organization based out in Minsk, Belarus. It is known for research contribution in the topics: Population & Medicine. The organization has 536 authors who have published 513 publications receiving 4635 citations.

Pro-oxidant effects of Mebendazole in albino rats experimentally infected with Trichinella spiralis

Abstract: Trichinellosis treated with Mebendazole often leads to complications in the course of the disease in humans and animals as a result of intoxication and hyper-sensitization of an organism due to the massive destruction of parasites. This study was conducted to research Mebendazole incidence on lipid peroxidation processes (LPP) in rats’ blood in Trichinella spiralis-infected and parasite-free albino rats. The research was conducted to evaluate erythrocyte superoxide dismutase (SOD) activity and malonic dialdehyde (MDA) concentration in blood serum. The parameters of the SOD–MDA system in infected albino rats, which were treated or untreated with Mebendazole were analyzed. It was concluded that Mebendazole amplifies the LPP in the blood of both infected and parasite-free animals: in a dose of 150 mg/kg anthelmintic causes disturbances of biochemical homeostasis in the SOD–MDA system, thus working as a pro-oxidant.

The significance of the expression of matrix metalloproteinases in the differential diagnosis of periodontal diseases

Abstract: Investigation of features of expression of matrix metalloproteinases (MMPs) is important for both understanding the mechanisms of the pathogenesis of periodontal diseases, and determining the nature of their course in order to choose a correct and timely treatment strategy. OBJECTIVE To establish the value of MMPs for the diagnosis and determination of the nature of the course of periodontitis at the stage of disease manifestation, by morphometrically assessing the expression of MMPs in the gingival biopsy material. MATERIAL AND METHODS Gingival biopsy specimens from 82 patients with rapidly progressing (n=26), chronic simple (n=18), and chronic complex (n=38) periodontitis were analyzed. Morphometric and statistical analysis of the expression of MMPs was carried out using Aperio ImageScope v. 12.4.0.5043, Statistica 10.0, and MedCalc (p<0.05). RESULTS Analysis of the nature of MMP expression in the gingival biopsy material of patients with periodontal diseases showed that MMP2 and MMP13 were approximately equally involved in the development and course of all the studied forms of periodontitis. An increase in the expression of MMP1, MMP8, and MMP14 and a decrease in that of MMP9 are of the greatest importance in the pathogenesis of a rapidly progressing process. The performed ROC analysis confirmed the significance of the parameters of general and stromal expression of MMP1, MMP9, and MMP14, and mainly stromal expression of MMP8 for the differential diagnosis of rapidly progressing periodontitis with chronic forms, including chronic complex periodontitis. CONCLUSION The expression indicators of MMR1, MMR8, MMR9, and MMR14 are most informative in determining the course of periodontitis at the stage of disease manifestation and differential diagnosis of rapidly progressing periodontitis with chronic simplex and complex periodontitis.

[The agreed experts' position of the Eurasian Association of Therapists on tactics of management of patients with comorbid pathology infected with SARS-Cov-2].

Abstract: The agreement of experts of the Eurasian Association of Therapists (EAT) discusses pathogenesis and treatment of COVID-19. Modern data on the characteristics of cardiovascular, kidney, respiratory damage in SARS-infected CoV-2 are presented. The tactics of managing patients initially having cardiovascular diseases, diabetes mellitus, chronic obstructive pulmonary disease, bronchial asthma, chronic kidney disease are discussed in detail. The article presents data on drug interaction of drugs.

Multi-level System Coupling of Error Commission, Detection and Correction in the Error Monitoring and Processing System are Required for High Precision Task Performance, and Modulates Neural Plasticity through Changes in Glucoallostasis

Abstract: High precision of task performance is required in almost all activities of humans and non-human subjects – the hallmark of the functioning of the error monitoring and processing system (EMPS). In many cases, however, task precision is affected by the level of error commission, which decreases the quality of work or task performance. But error commission is an integral component of the EMPS. Previously we have estimated the physiological range of error commission to be around 5%. This suggests that above the physiological range, error commission is a negative coupling factor in the EMPS. However, even at the physiological range of error commission, the rate of error detection and concomitant correction, which are required to improve task precision, differs in many subjects. In conditions of correct performance of task, precision is promoted, and thus, represents a positive coupling factor in the EMPS. Therefore, error commission, detection and correction represent integral components required for high precision task performance. Been the main energy substrate for neural activity, glucose modulates several domains of EMPS. Interestingly, the main components of EMPS functioning – error commission, correction and detection are associated with changes in glucoallostasis. Here we propose the high precision functioning of EMPS involves coupling at different levels of error commission, correction and detection. Further we suggest that this multilevel coupling modulates neural plasticity through changes in glucoallostasis. This work provides a conceptual background to the modeling of high precision task performance in human and non-human subjects.