Birla Institute of Technology, Mesra

About: Birla Institute of Technology, Mesra is a education organization based out in Ranchi, India. It is known for research contribution in the topics: Computer science & Dielectric. The organization has 2801 authors who have published 4789 publications receiving 52426 citations. The organization is also known as: BIT.

Groundwater vulnerability and contamination risk assessment using GIS-based modified DRASTIC-LU model in hard rock aquifer system in India

Abstract: Groundwater vulnerability and risk assessment is an essential step for preventing and controlling contamination in any area. DRASTIC model with modification incorporating land use (LU) widely used ...

Evaluation of Gum of Moringa oleifera as a Binder and Release Retardant in Tablet Formulation

Abstract: The present study was undertaken to find out the potential of gum from Moringa oleifera to act as a binder and release retardant in tablet formulations. The effect of calcium sulphate dihydrate (water insoluble) and lactose (water soluble) diluent on the release of propranolol hydrochloride was studied. The DSC thermograms of drug, gum and mixture of gum/drug indicated no chemical interaction. Tablets (F1, F2, F3, and F4) were prepared containing calcium sulphate dihydrate as diluent, propranolol hydrochloride as model drug using 10%, 8%, 6% and 4% w/v of gum solution as binder. Magnesium stearate was used as lubricant. Physical and technological properties of granules and tablets like flow rate, Carr index, Hausner ratio, angle of repose, hardness, friability and disintegration time were determined and found to be satisfactory. Tablets were prepared by wet granulation method containing calcium sulphate dihydrate as excipient, propranolol hydrochloride as model drug using 10%, 20% and 30% of gum as release retardant, magnesium stearate was used as lubricant. Similarly tablets were prepared replacing lactose with calcium sulphate dihydrate. Despite of the widely varying physico-chemical characteristics of the excipients, the drug release profiles were found to be similar. The drug release increased with increasing proportions of the excipient and decreased proportion of the gum irrespective of the solubility characteristics of the excipient. The values of release exponent 'n' are between 0.37 and 0.54. This implies that the release mechanism is Fickian. There is no evidence that the dissolution or erosion of the excipient has got any effect on the release of the drug. The t(50%) values for tablets containing calcium sulphate dihydrate were on an average 10%-15% longer than the tablets containing lactose as excipient. These relatively small differences in t(50%) values suggest that the nature of excipient used appeared to play a minor role in regulating the release, while the gum content was a major factor.

Polyacrylamide Grafted Carboxymethyl Tamarind (CMT‐g‐PAM): Development and Application of a Novel Polymeric Flocculant

Abstract: Water is scarce commodity now. Recycling of municipal wastewater, industrial and mineral processing effluents require treatment with the inorganic or organic flocculants. Both synthetic and natural polymers are used as flocculants. Natural polymers are biodegradable and are effective at very large dosages but are very shear stable. The synthetic polymers are highly effective flocculants at very small dosages and have high tailorability, but have poor shear stability. In the authors' laboratory, a novel polymeric flocculant has been developed by grafting polyacrylamide onto the backbone of carboxymethyl tamarind (CMT-g-PAM). Various grades were developed to optimize the best flocculant. The grafted polymers were characterized by various characterization techniques such as intrinsic viscosity measurement, FTIR spectroscopy, 13 C-NMR spectroscopy, elemental analysis etc. The flocculation studies were carried out using turbidity test as well as settling test. The optimized CMT-g-PAM was then compared with some of the commercial flocculants available in national and international markets in colloidal suspensions and it has been found that our synthesized flocculant surpasses most of the commercial flocculants in performance.