Birla Institute of Technology, Mesra

About: Birla Institute of Technology, Mesra is a education organization based out in Ranchi, India. It is known for research contribution in the topics: Computer science & Dielectric. The organization has 2801 authors who have published 4789 publications receiving 52426 citations. The organization is also known as: BIT.

Optimization of physical and morphological regime for improved cellulase free xylanase production by fed batch fermentation using Aspergillus niger (KP874102.1) and its application in bio-bleaching.

Abstract: The physiological and morphological changes were extensively studied during fed batch fermentation using newly isolated Aspergillus niger (KP8741021) Significantly higher xylanase production was possible through optimization of environmental stresses by fed batch process The fed batch fermentation was carried out for improved xylanase production (2524 U) where initial xylan was kept 15 g/L in the production medium However, 3 g/L of xylan with 50 mM K2HPO4 having pH-7 was consecutively fed at 72 and 120 h of fermentation K2HPO4 showed significant role both the morphology of the microorganism and produces enzymes in fed batch fermentation During feeding phase, the pH was found in the range of 65 to 7 which was used as marker for the fed batch process The crude enzyme was used for the bio-bleaching of banana pulp

Fabrication of lipidic nanocarriers of loratadine for facilitated intestinal permeation using multivariate design approach.

Abstract: In this investigation, multivariate design approach was employed to develop self-nanoemulsifying drug delivery system (SNEDDS) of loratadine and to exploit its potential for intestinal permeability. Drug solubility was determined in various vehicles and existence of self-nanoemulsifying region was evaluated by phase diagram studies. The influence of formulation variables X1 (Capmul MCM C8) and X2 (Solutol HS15) on SNEDDS was assessed for mean globule sizes in different media (Y1–Y3), emulsification time (Y4) and drug-release parameters (Y5–Y6), to improve quality attributes of SNEDDS. Significant models were generated, statistically analyzed by analysis of variance and validated using the residual and leverage plots. The interaction, contour and response plots explicitly demonstrated the influence of one factor on the other and displayed trend of factor-effect on responses. The pH-independent optimized formulation was obtained with appreciable global desirability (0.9266). The strenuous act of det...