British Hospital

About: British Hospital is a healthcare organization based out in Montevideo, Uruguay. It is known for research contribution in the topics: Population & Hazard ratio. The organization has 445 authors who have published 358 publications receiving 7878 citations. The organization is also known as: British Hospital.

Long-Term Response and Possible Cure of Patients With B-Cell Malignancies With Dose-Escalated Rituximab.

Abstract: Rituximab (R), a chimeric monoclonal antibody targeting CD20 antigen on B-cells, has become a standard of care in the treatment of B-cell malignancies, most often in conjunction with cytotoxic chemotherapy. Activity has been demonstrated in many subtypes of B-cell lymphoma, including diffuse large cell lymphoma, follicular lymphoma (FL), mantle cell lymphoma (MCL), chronic lymphocytic leukemia (CLL), lymphocyte-predominant Hodgkin lymphoma, and Waldenstrom macroglobulinemia (WM). Additionally, dose escalation of R as a single agent has demonstrated improved activity in previously treated/poor prognosis CLL. We present 4 cases of B-cell malignancy (2 CLL variants/MCL, 1 FL, 1 WM) who received dose-escalated R as a single agent and achieved complete response (3 patients) and stable disease/partial response (1 patient) of 6.5+ to 15+ years duration. They have been off treatment for 6.5+ to 15+ years. Toxicity was minimal, with initial infusion reactions similar to those observed with standard dose infusions. There were no serious treatment-related adverse events or infections. Dose escalated R as a single agent may possibly be curative for some patients with B-cell malignancies, unlike the standard empiric dose of 375 mg/m2, and deserves further study.

Reflectance confocal microscopy as a noninvasive complementary tool in the diagnosis of psoriatic balanitis

Abstract: Genital lesions are estimated to occur in 30-40% of patients with psoriasis with a slight predominance in men. Less frequently they are the first, and rarely the sole presentation of this common inflammatory disease in only 2-5% of affected patients.1 Therefore, its differential diagnosis can be wide, including mainly inflammatory diseases. This article is protected by copyright. All rights reserved.

What the radiologist needs to know about restaging of rectal carcinoma after chemoradiation therapy

Abstract: Aim The purpose of this exhibit is to describe and compare the high-resolution MRI features of rectal carcinoma after chemoradiation treatment (CRT) and to correlate with the histologic findings after total mesorectal excision (TME). Method High resolution T2-W MR imaging (HRMRI) was performed in a 1.5 T unit between January 2013 and February 2014 before and immediately after CRT in the care of 25 patients with locally advanced adenocarcinoma of the rectum. After total mesorectal excision (TME) the piece was cut by the pathologist under the supervision of the radiologist, who indicated areas of residual tumour after neoadjuvant therapy or changes such as fibrosis, oedema, cellular and acellular mucin, desmoplastic reaction and pseudotumour appearance. Thus, initially we did a correlation between the macroscopic and MR imaging. Subsequently, we performed the same correlation but in this case between microscopy and MR imaging. Changes in morphologic and signal intensity features were evaluated with respect to primary tumour and nodal downstaging. Summary Emerging evidence has shown the prognostic importance of reassessing rectal cancer using HRMRI after completion of CRT. A systematic cooperation between radiologist and pathologist is essential for optimal treatment planning and patient care.

Entirely thoracoscopic resection of a giant emphysematous bulla.

Abstract: A 38-year-old man with longilinear shape, smoker (38 packs/year) and no other relevant medical history was referred to our department due to the finding of left pulmonary hyperlucency on a chest x-ray. A computed tomography (CT) was performed and a giant emphysematous bulla with thin-walled partitions inside was shown that replaced almost the entire left upper lobe, The patient underwent an exploratory thoracoscopy. Intraoperatively a giant bulla was seen that initially impressed to replace the entire upper lobe. Despite the large size we decided to attempt thoracoscopic resection preserving the remaining healthy parenchyma. Bullectomy was done using linear endoscopic stapling devices. To our knowledge this is the only case with such a large bulla resected entirely by VATS. Keywords: giant bulla, bullectomy, VATS