Institution
British Hospital
Healthcare•Montevideo, Uruguay•
About: British Hospital is a healthcare organization based out in Montevideo, Uruguay. It is known for research contribution in the topics: Population & Hazard ratio. The organization has 445 authors who have published 358 publications receiving 7878 citations. The organization is also known as: British Hospital.
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University of Otago1, University of Regensburg2, Trinity College, Dublin3, University of Salzburg4, University of Zurich5, University College London6, Seoul National University Bundang Hospital7, Linköping University8, Nottingham University Hospitals NHS Trust9, British Hospital10, Katholieke Universiteit Leuven11, University of Calgary12, Maastricht University13, Mario Negri Institute for Pharmacological Research14, University of Antwerp15, University of Nottingham16, Assiut University17, National and Kapodistrian University of Athens18, University of Valencia19, University of Minnesota20, National Taiwan University21, University of Granada22, Charité23, University of Texas at Dallas24, University of Münster25, Catholic University of Korea26, Washington University in St. Louis27, RWTH Aachen University28, Georgetown University29, University at Buffalo30, University of São Paulo31, University of Auckland32, Wayne State University33
TL;DR: In this article, the authors proposed that the tinnitus without and with associated suffering should be differentiated by distinct terms: "Tinnitus" for the former and Tinnitus Disorder for the latter, which is the conscious awareness of a tonal or composite noise for which there is no identifiable corresponding external acoustic source.
Abstract: As for hypertension, chronic pain, epilepsy and other disorders with particular symptoms, a commonly accepted and unambiguous definition provides a common ground for researchers and clinicians to study and treat the problem. The WHO's ICD11 definition only mentions tinnitus as a nonspecific symptom of a hearing disorder, but not as a clinical entity in its own right, and the American Psychiatric Association's DSM-V doesn't mention tinnitus at all. Here we propose that the tinnitus without and with associated suffering should be differentiated by distinct terms: "Tinnitus" for the former and "Tinnitus Disorder" for the latter. The proposed definition then becomes "Tinnitus is the conscious awareness of a tonal or composite noise for which there is no identifiable corresponding external acoustic source, which becomes Tinnitus Disorder "when associated with emotional distress, cognitive dysfunction, and/or autonomic arousal, leading to behavioural changes and functional disability.". In other words "Tinnitus" describes the auditory or sensory component, whereas "Tinnitus Disorder" reflects the auditory component and the associated suffering. Whereas acute tinnitus may be a symptom secondary to a trauma or disease, chronic tinnitus may be considered a primary disorder in its own right. If adopted, this will advance the recognition of tinnitus disorder as a primary health condition in its own right. The capacity to measure the incidence, prevalence, and impact will help in identification of human, financial, and educational needs required to address acute tinnitus as a symptom but chronic tinnitus as a disorder.
97 citations
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TL;DR: Extramedullary acute promyelocytic leukemia (APL) is rare, and said to be more common after treatment with all‐trans retinoic acid (ATRA) than after any other treatment.
Abstract: BACKGROUND
Extramedullary acute promyelocytic leukemia (APL) is rare, and said to be more common after treatment with all-trans retinoic acid (ATRA) than after any other treatment.
METHODS
The case of a child with extramedullary relapse of APL after initial treatment with ATRA and that of an adult whose initial treatment was chemotherapy are presented, and the literature on extramedullary relapse of APL is reviewed.
RESULTS
Twenty-six patients were identified, including the 2 current patients. Ethnicity could be determined in 23 patients, 17 of whom were of other than Northern European extraction. The most common sites of extramedullary disease were the skin (15 patients), central nervous system (5 patients), mediastinum (3 patients), and, curiously, gingiva (3 patients). Extramedullary leukemia developed in 19 patients: after treatment with ATRA (6 patients), cytotoxic chemotherapy (12 patients), or both (1 patient), and developed in 7 others before any treatment for leukemia was given.
CONCLUSIONS
These data suggest but do not prove that extramedullary APL may occur more frequently after ATRA than other therapy, since ATRA has been available for a relatively short period of time. However, it is clear from the literature that extramedullary APL may occur after chemotherapy or before any treatment. Cancer 1996; 78:2510-4.
95 citations
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Versailles Saint-Quentin-en-Yvelines University1, Paris Descartes University2, La Roche College3, University of Paris4, Aix-Marseille University5, Paris-Sorbonne University6, University of Toulouse7, Beaujon Hospital8, Université Paris-Saclay9, French Institute of Health and Medical Research10, European University11, British Hospital12
TL;DR: These guidelines for management of PA are continuously evolving and need to be regularly updated, as each individual case is particular, they cannot substitute to multidisciplinary tumor board discussion.
95 citations
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Paris Diderot University1, British Hospital2, Paris Descartes University3, La Roche College4, François Rabelais University5, University of Rouen6, University of Nantes7, University of Clermont-Ferrand8, St. Joseph Hospital9, Saint Louis University Hospital10, Institut Gustave Roussy11, Cochin University of Science and Technology12, French Institute of Health and Medical Research13, University of Grenoble14
TL;DR: Among patients who received mechanical ventilation in the ICU, the use of an ICU diary filled in by clinicians and family members did not significantly reduce the number of patients who reported significant PTSD symptoms at 3 months, and these findings do not support theUse of ICU diaries for preventing PTSD symptoms.
Abstract: Importance Keeping a diary for patients while they are in the intensive care unit (ICU) might reduce their posttraumatic stress disorder (PTSD) symptoms. Objectives To assess the effect of an ICU diary on the psychological consequences of an ICU hospitalization. Design, Setting, and Participants Assessor-blinded, multicenter, randomized clinical trial in 35 French ICUs from October 2015 to January 2017, with follow-up until July 2017. Among 2631 approached patients, 709 adult patients (with 1 family member each) who received mechanical ventilation within 48 hours after ICU admission for at least 2 days were eligible, 657 were randomized, and 339 were assessed 3 months after ICU discharge. Interventions Patients in the intervention group (n = 355) had an ICU diary filled in by clinicians and family members. Patients in the control group (n = 354) had usual ICU care without an ICU diary. Main Outcomes and Measures The primary outcome was significant PTSD symptoms, defined as an Impact Event Scale-Revised (IES-R) score greater than 22 (range, 0-88; a higher score indicates more severe symptoms), measured in patients 3 months after ICU discharge. Secondary outcomes, also measured at 3 months and compared between groups, included significant PTSD symptoms in family members; significant anxiety and depression symptoms in patients and family members, based on a Hospital Anxiety and Depression Scale score greater than 8 for each subscale (range, 0-42; higher scores indicate more severe symptoms; minimal clinically important difference, 2.5); and patient memories of the ICU stay, reported with the ICU memory tool. Results Among 657 patients who were randomized (median [interquartile range] age, 62 [51-70] years; 126 women [37.2%]), 339 (51.6%) completed the trial. At 3 months, significant PTSD symptoms were reported by 49 of 164 patients (29.9%) in the intervention group vs 60 of 175 (34.3%) in the control group (risk difference, −4% [95% CI, −15% to 6%];P = .39). The median (interquartile range) IES-R score was 12 (5-25) in the intervention group vs 13 (6-27) in the control group (difference, −1.47 [95% CI, −1.93 to 4.87];P = .38). There were no significant differences in any of the 6 prespecified comparative secondary outcomes. Conclusions and Relevance Among patients who received mechanical ventilation in the ICU, the use of an ICU diary filled in by clinicians and family members did not significantly reduce the number of patients who reported significant PTSD symptoms at 3 months. These findings do not support the use of ICU diaries for preventing PTSD symptoms. Trial Registration ClinicalTrials.gov Identifier:NCT02519725
93 citations
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TL;DR: These evidence-based clinical guidelines on hypothyroidism will provide unified criteria for management of hyp Timothyroidism throughout Latin America.
Abstract: INTRODUCTION: Hypothyroidism has long been known for its effects on different organ systems, leading to hypometabolism. However, subclinical hypothyroidism, its most prevalent form, has been recently related to cardiovascular risk and also to maternal-fetal complications in pregnant women. OBJECTIVES: In these clinical practice guidelines, several aspects of this field have been discussed with the clear objectives of helping physicians treat patients with hypothyroidism, and of sharing some of our Latin American-based clinical experience. MATERIALS AND METHODS: The Latin American Thyroid Society commissioned a Task Force on Hypothyroidism to develop evidence-based clinical guidelines on hypothyroidism. A systematic review of the available literature, focused on the primary databases of MedLine/PubMed and Lilacs/SciELO was performed. Filters to assess methodological quality were applied to select the best quality studies. The strength of recommendation on a scale from A-D was based on the Oxford Centre for Evidence--based Medicine, Levels of Evidence 2009, allowing an unbiased opinion devoid of subjective viewpoints. The areas of interest for the studies comprised diagnosis, screening, treatment and a special section for hypothyroidism in pregnancy. RESULTS: Several questions based on diagnosis, screening, treatment of hypothyroidism in adult population and specifically in pregnant women were posed. Twenty six recommendations were created based on the answers to these questions. Despite the fact that evidence in some areas of hypothyroidism, such as therapy, is lacking, out of 279 references, 73% were Grade A and B, 8% Grade C and 19% Grade D. CONCLUSIONS: These evidence-based clinical guidelines on hypothyroidism will provide unified criteria for management of hypothyroidism throughout Latin America. Although most of the studies referred to are from all over the world, the point of view of thyroidologists from Latin America is also given.
92 citations
Authors
Showing all 445 results
Name | H-index | Papers | Citations |
---|---|---|---|
Maité Garrouste-Orgeas | 62 | 157 | 13270 |
A. de Gramont | 41 | 178 | 11918 |
Ricardo F. Allegri | 33 | 220 | 3577 |
Benoist Chibaudel | 32 | 141 | 4272 |
Emmanuel Marret | 29 | 98 | 4779 |
Federico G. Villamil | 26 | 82 | 3829 |
Oscar E. Martínez | 25 | 174 | 4785 |
Daniel Moya | 21 | 82 | 1236 |
João Guimarães | 19 | 30 | 2206 |
Silvia Quadrelli | 18 | 110 | 1095 |
Jose C. Russi | 17 | 25 | 761 |
Alvaro Campero | 17 | 94 | 1230 |
Hernán Trimarchi | 17 | 79 | 1207 |
Matias Bruzoni | 16 | 46 | 845 |
Hamlet Suarez | 16 | 41 | 914 |