Capital Normal University

About: Capital Normal University is a education organization based out in Beijing, China. It is known for research contribution in the topics: Terahertz radiation & Quantum entanglement. The organization has 11441 authors who have published 11988 publications receiving 159071 citations. The organization is also known as: Shǒudū Shīfàn Dàxué.

Modulation of LSD1 phosphorylation by CK2/WIP1 regulates RNF168-dependent 53BP1 recruitment in response to DNA damage

Abstract: Proper DNA damage response is essential for the maintenance of genome integrity The E3 ligase RNF168 deficiency fully prevents both the initial recruitment and retention of 53BP1 at sites of DNA damage In response to DNA damage, RNF168-dependent recruitment of the lysine-specific demethylase LSD1 to the site of DNA damage promotes local H3K4me2 demethylation and ubiquitination of H2A/H2AX, facilitating 53BP1 recruitment to sites of DNA damage Alternatively, RNF168-mediated K63-linked ubiquitylation of 53BP1 is required for the initial recruitment of 53BP1 to sites of DNA damage and for its function in repair We demonstrated here that phosphorylation and dephosphorylation of LSD1 at S131 and S137 was mediated by casein kinase 2 (CK2) and wild-type p53-induced phosphatase 1 (WIP1), respectively LSD1, RNF168 and 53BP1 interacted with each other directly CK2-mediated phosphorylation of LSD1 exhibited no impact on its interaction with 53BP1, but promoted its interaction with RNF168 and RNF168-dependent 53BP1 ubiquitination and subsequent recruitment to the DNA damage sites Furthermore, overexpression of phosphorylation-defective mutants failed to restore LSD1 depletion-induced cellular sensitivity to DNA damage Taken together, our results suggest that LSD1 phosphorylation modulated by CK2/WIP1 regulates RNF168-dependent 53BP1 recruitment directly in response to DNA damage and cellular sensitivity to DNA damaging agents

Two-dimensional Poisson Trees converge to the Brownian web

Abstract: The Brownian web can be roughly described as a family of coalescing one-dimensional Brownian motions starting at all times in R and at all points of R . The two-dimensional Poisson tree is a family of continuous time one-dimensional random walks with uniform jumps in a bounded interval. The walks start at the space–time points of a homogeneous Poisson process in R 2 and are in fact constructed as a function of the point process. This tree was introduced by Ferrari, Landim and Thorisson. By verifying criteria derived by Fontes, Isopi, Newman and Ravishankar, we show that, when properly rescaled, and under the topology introduced by those authors, Poisson trees converge weakly to the Brownian web.

Two-dimensional ferromagnetic-ferroelectric multiferroics in violation of the d 0 rule

Abstract: Contribution of a $d$ electron to ferroelectricity of type-II multiferroics causes strong magnetoelectric coupling and distinguishes them from the conventional type-I multiferroics. However, their therein polarization is too small because the ferroelectricity is merely a derivative from the magnetic order. Here we report a class of multiferroic materials, monolayer $\mathrm{VO}{X}_{2}$ ($X=\mathrm{Cl}$, Br, and I), which combine the advantages of type-I and type-II multiferroics. Both ferroelectricity and magnetism arise from the same V cation, where the filled $d$ orbital is perpendicular to an a priori ferroelectric polarization and thus poses no hindrance to ferroelectricity, indicating a violation of the usual ${d}^{0}$ rule. This makes the combination of large polarizations and strong magnetoelectric coupling possible. Our findings not only add new ferromagnetic-ferroelectric multiferroics, but also point to a unique mechanism to engineer multiferroics.