Capital Normal University

About: Capital Normal University is a education organization based out in Beijing, China. It is known for research contribution in the topics: Terahertz radiation & Quantum entanglement. The organization has 11441 authors who have published 11988 publications receiving 159071 citations. The organization is also known as: Shǒudū Shīfàn Dàxué.

Biorecognition-Driven Self-Assembly of Gold Nanorods: A Rapid and Sensitive Approach toward Antibody Sensing

Abstract: The surface of gold nanorods (GNRs) with average aspect ratio 3.5 functionalized by poly(styrene sulfonate) for the attachment of goat anti-h-IgG yielded GNR molecular probes, which exhibited the rapid and sensitive detection of h-IgG by localized surface plasmon absorption (LSPR). The detection limit of the present method is 60 ng mL−1. This novel method using GNRs with different aspect ratios is simple and sensitive, may provide a novel optical multiplex biosensor platform, and has broad potential applications in immunoassay and disease diagnosis.

Arabidopsis CSN5B Interacts with VTC1 and Modulates Ascorbic Acid Synthesis

Abstract: Light regulates ascorbic acid (AsA) synthesis, which increases in the light, presumably reflecting a need for antioxidants to detoxify reactive molecules produced during photosynthesis. Here, we examine this regulation in Arabidopsis thaliana and find that alterations in the protein levels of the AsA biosynthetic enzyme GDP-Man pyrophosphorylase (VTC1) are associated with changes in AsA contents in light and darkness. To find regulatory factors involved in AsA synthesis, we identified VTC1-interacting proteins by yeast two-hybrid screening of a cDNA library from etiolated seedlings. This screen identified the photomorphogenic factor COP9 signalosome subunit 5B (CSN5B), which interacted with the N terminus of VTC1 in yeast and plants. Gel filtration profiling showed that VTC1-CSN5B also associated with the COP9 signalosome complex, and this interaction promotes ubiquitination-dependent VTC1 degradation through the 26S proteasome pathway. Consistent with this, csn5b mutants showed very high AsA levels in both light and darkness. Also, a double mutant of csn5b with the partial loss-of-function mutant vtc1-1 contained AsA levels between those of vtc1-1 and csn5b, showing that CSN5B modulates AsA synthesis by affecting VTC1. In addition, the csn5b mutant showed higher tolerance to salt, indicating that CSN5B regulation of AsA synthesis affects the response to salt stress. Together, our data reveal a regulatory role of CSN5B in light-dark regulation of AsA synthesis.

The Campaign on Atmospheric Aerosol Research Network of China: CARE-China

Abstract: Based on a network of field stations belonging to the Chinese Academy of Sciences (CAS), the Campaign on Atmospheric Aerosol Research network of China (CARE-China) was recently established as the country’s first monitoring network for the study of the spatiotemporal distribution of aerosol physical characteristics, chemical components, and optical properties, as well as aerosol gaseous precursors. The network comprises 36 stations in total and adopts a unified approach in terms of the instrumentation, experimental standards, and data specifications. This ongoing project is intended to provide an integrated research platform to monitor online PM2.5 concentrations, nine-size aerosol concentrations and chemical component distributions, nine-size secondary organic aerosol (SOA) component distributions, gaseous precursor concentrations (including SO2, NOx, CO, O3, and VOCs), and aerosol optical properties. The data will be used to identify the sources of regional aerosols, the relative contributions fr...