Capital Normal University

About: Capital Normal University is a education organization based out in Beijing, China. It is known for research contribution in the topics: Terahertz radiation & Quantum entanglement. The organization has 11441 authors who have published 11988 publications receiving 159071 citations. The organization is also known as: Shǒudū Shīfàn Dàxué.

Functions and mechanisms of the CBL–CIPK signaling system in plant response to abiotic stress

Abstract: To cope with environmental stimuli, plants have evolved precise regulatory mechanisms to perceive, transduce and respond to abiotic stresses that can negatively affect growth and development. The CBL–CIPK signaling system is a newly emerging plant-specific and Ca2+-dependent network mediating abiotic stress tolerance. CBLs may sense a Ca2+ signature triggered by abiotic stresses, and have specific interactions with novel CIPK-type kinases after binding Ca2+. The CBL/CIPK complexes may post-translationally phosphorylate downstream target proteins to regulate abiotic stress tolerance in a cell or tissue-specific manner. In some cases transcription factors are induced to activate stress-responsive genes that control adaptation reactions. The CBL–CIPK signaling system exhibits specificity, diversity and complexity. Meanwhile, cross talk also exists in the CBL–CIPK signaling. To date, significant progress has been made in the role of the CBL–CIPK signaling system in responding to salt, low K+ and to high pH, which will provide a fast and efficient method of molecular design breeding combined with the CBL/CIPK engineering of crop plants, for enhanced tolerance to abiotic stresses. However, more CBL/CIPK components remain to be identified, particularly from specific plants that grow in conditions with abiotic stress, and the specificity of their abiotic stress signaling will need to be dissected.

Biocompatible Heat-Shock Protein Inhibitor-Delivered Flowerlike Short-Wave Infrared Nanoprobe for Mild Temperature-Driven Highly Efficient Tumor Ablation.

Abstract: Multifunctional nanomaterials for dual-mode imaging guided cancer therapy are highly desirable in clinical applications. Herein, a flowerlike NiS2-coated NaLuF4:Nd (Lu:Nd@NiS2) nanoparticle was synthesized as a novel therapeutic agent for short-wave infrared light imaging and magnetic resonance imaging to guide photothermal therapy (PTT). The material was then loaded with phenolic epigallocatechin 3-gallate (EGCG), which is a natural heat-shock protein 90 (HSP90) inhibitor. Upon near infrared irradiation, EGCG was released from the Lu:Nd@NiS2-EGCG, which bound HSP90 and reduced cell tolerance to heat, resulting in a better therapeutic effect at the same elevated temperature. Therefore, with minimal side effects and remarkable antitumor efficacy in vivo, Lu:Nd@NiS2-EGCG appeared to be a promising photothermal agent for enhanced PTT.

Applications of Graphene-Based Materials in Solid-Phase Extraction and Solid-Phase Microextraction

Abstract: Graphene, a carbon nanomaterial made of a two-dimensional layer of a single atome thick with 100% sp2 hybridization C, has exhibited excellent adsorption capacity for sample preparation in analytical science. This review will provide an overview of the applications of graphene-based materials in sample preparation based on π-π interaction between the graphene layers and aromatic containing analytes. In the field of sample preparation, solid-phase extraction (SPE) is performed passing the sample solution onto a graphene containing cartridge for selective retention of analytes. Solid-phase microextraction (SPME) is performed using small graphene-coated fibers plunged into the liquid sample to extract analytes later desorbed by heat in a gas chromatography injector. In this review, recent applications of graphene and its composites for SPE and SPME are summarized, and future applications of graphene and graphene-based materials are discussed.