Institution
Dartmouth College
Education•Hanover, New Hampshire, United States•
About: Dartmouth College is a education organization based out in Hanover, New Hampshire, United States. It is known for research contribution in the topics: Population & Health care. The organization has 20740 authors who have published 51426 publications receiving 2796969 citations. The organization is also known as: Dartmouth.
Topics: Population, Health care, Cancer, Mental health, Poison control
Papers published on a yearly basis
Papers
More filters
••
TL;DR: In this paper, three-dimensional, ideal MHD simulations of Earth's bow shock are reported for low Alfven Mach numbers M(sub A) and quasi-perpendicular magnetic field orientations.
Abstract: Global, three-dimensional, ideal MHD simulations of Earth's bow shock are reported for low Alfven Mach numbers M(sub A) and quasi-perpendicular magnetic field orientations. The simulations use a hard, infinitely conducting magnetopauause obstacle, with axisymmetric three-dimensional location given by scaled standard model, to directly address previous gasdynamic (GD) and field-aligned MHD (FA-MHD) work. Tests of the simulated shocks' density jumps X for 1.4 approx. less than MA approx. less than 10 and the high M(sub A) shock location, and reproduction of the GD relation between magnetosheath thickness and X for quasi-gasdynamic MHD runs with M(sub A) much greater than M(sub s), confirm that the MHD code is working correctly. The MHD simulations show the standoff distance a(sub s), increasing monotonically with decreasing M(sub A). Significantly larger a(sub s), are found at low M(sub A) than predicted by GD and phenomenological MHD models and FA-MHD simulations, as required qualitatively by observations. The GD and FA-MHD predictions err qualitatively, predicting either constant or decreasing a(sub s), with decreasing M(sub A). This qualitative difference between quasi- perpendicular MHD and FA-MHD simulations is direct evidence for a(sub s), depending on the magnetic field orientation Theta. The enhancement factor over the phenomenological MHD predictions at MA approx. 2.4 agrees quantitatively with one observatiorial estimate. A linear relationship is found between the magnetosheath thickness and X, modified both quantitatively and intrinsically by MHD effects from the GD result. The MHD and GD results agree in the high M(sub A) limit. An MHD theory is developed for a(sub s), restricted to sufficiently perpendicular Theta and high sonic Mach numbers M(sub s). It explains the simulation results with excellent accuracy. Observational and further simulation testing of this MHD theory, and of its predicted M(sub A), Theta, and M(sub s) effects, is desirable.
70 citations
••
TL;DR: Comparisons demonstrate the superior heating properties of the Dartmouth MNPs at low field strengths (<250 Oe), potentially enabling the treatment of some of the most difficult cancers, such as pancreatic and rectal cancers, without damaging normal tissue.
Abstract: Magnetic nanoparticles (MNPs), referred to as the Dartmouth MNPs, which exhibit high specific absorption rate at low applied field strength have been developed for hyperthermia therapy applications. The MNPs consist of small (2–5 nm) single crystals of gamma-Fe2O3 with saccharide chains implanted in their crystalline structure, forming 20–40 nm flower-like aggregates with a hydrodynamic diameter of 110–120 nm. The MNPs form stable (>12 months) colloidal solutions in water and exhibit no hysteresis under an applied quasistatic magnetic field, and produce a significant amount of heat at field strengths as low as 100 Oe at 99–164 kHz. The MNP heating mechanisms under an alternating magnetic field (AMF) are discussed and analyzed quantitatively based on (a) the calculated multi-scale MNP interactions obtained using a three dimensional numerical model called the method of auxiliary sources, (b) measured MNP frequency spectra, and (c) quantified MNP friction losses based on magneto-viscous theory. The frequency responses and hysteresis curves of the Dartmouth MNPs are measured and compared to the modeled data. The specific absorption rate of the particles is measured at various AMF strengths and frequencies, and compared to commercially available MNPs. The comparisons demonstrate the superior heating properties of the Dartmouth MNPs at low field strengths (<250 Oe). This may extend MNP hyperthermia therapy to deeper tumors that were previously non-viable targets, potentially enabling the treatment of some of the most difficult cancers, such as pancreatic and rectal cancers, without damaging normal tissue.
70 citations
••
TL;DR: 3 broad categories emerged surrounding reasons that patients were perceived to be less suitable candidates for the treatments: the presence of psychiatric comorbidities, cognitive limitations, and low levels of patient motivation.
Abstract: Providers (N = 198) from 38 Department of Veterans Affairs residential posttraumatic stress disorder treatment programs across the United States completed qualitative interviews regarding implementation of 2 evidence-based treatments: prolonged exposure and cognitive processing therapy. As part of this investigation, providers were asked how they decide which patients are appropriate for these treatments. Many indicated that they did not perceive any patient factors that dissuade their use of either evidence-based treatment. However, 3 broad categories emerged surrounding reasons that patients were perceived to be less suitable candidates for the treatments: the presence of psychiatric comorbidities, cognitive limitations, and low levels of patient motivation. Interestingly, providers' perceived reasons for limited or nonuse of a treatment did not correspond entirely to those espoused by treatment developers. Possible solutions to address provider concerns, including educational and motivational interventions, are noted.
70 citations
••
27 Oct 2003TL;DR: This paper proposes the development of an algorithmic basis for heterogeneous self-reconfiguring systems and demonstrates algorithmic feasibility by presenting O(n/sup 2/) time centralized and O( n/sup 3/) time decentralized solutions to the reconfiguration problem for n non-identical modules.
Abstract: Current research in self-reconfiguring robots focuses predominantly on systems of identical modules. However, allowing modules of varying types, with different sensors, for example, is of practical interest. In this paper, we propose the development of an algorithmic basis for heterogeneous self-reconfiguring systems. We demonstrate algorithmic feasibility by presenting O(n/sup 2/) time centralized and O(n/sup 3/) time decentralized solutions to the reconfiguration problem for n non-identical modules. As our centralized time bound is equal to the best published homogeneous solution, we argue that space, as opposed to time, is the critical resource in the reconfiguration problem. Our results encourage the development both of applications that use heterogeneous self-reconfiguration, and also heterogeneous hardware systems.
70 citations
••
TL;DR: In this article, a three-step sequence was developed for converting o -nitrobenzaldehydes into 2-nitroindoles, which achieved a 54% yield.
70 citations
Authors
Showing all 20952 results
Name | H-index | Papers | Citations |
---|---|---|---|
Richard A. Flavell | 231 | 1328 | 205119 |
Stuart H. Orkin | 186 | 715 | 112182 |
Paul G. Richardson | 183 | 1533 | 155912 |
Kenneth C. Anderson | 178 | 1138 | 126072 |
Yang Yang | 164 | 2704 | 144071 |
Michael B. Sporn | 157 | 559 | 94605 |
Kun-Liang Guan | 143 | 427 | 94520 |
Joseph E. LeDoux | 139 | 478 | 91500 |
Edward L. Glaeser | 137 | 550 | 83601 |
Carl Nathan | 135 | 430 | 91535 |
Nikhil C. Munshi | 134 | 906 | 67349 |
George A. Bray | 131 | 896 | 100975 |
Valerie W. Rusch | 131 | 581 | 73809 |
Kim A. Eagle | 129 | 823 | 75160 |
Gerald R. Crabtree | 128 | 371 | 60973 |