Delhi Technological University

About: Delhi Technological University is a education organization based out in New Delhi, India. It is known for research contribution in the topics: Computer science & Control theory. The organization has 4427 authors who have published 6761 publications receiving 71035 citations. The organization is also known as: Delhi College of Engineering & DTU.

Protein Functionalized Carbon Nanotubes-based Smart Lab-on-a-Chip

Abstract: A label-free impedimetric lab on a chip (iLOC) is fabricated using protein (bovine serum albumin) and antiapolipoprotein B functionalized carbon nanotubes–nickel oxide (CNT–NiO) nanocomposite for low-density lipoprotein (LDL) detection. The antiapolipoprotein B (AAB) functionalized CNT–NiO microfluidic electrode is assembled with polydimethylsiloxane rectangular microchannels (cross section: 100 × 100 μm). Cytotoxicity of the synthesized CNTs, NiO nanoparticles, and CNT–NiO nanocomposite has been investigated in the presence of lung epithelial cancer A549 cell line using MTT assay. The CNT–NiO nanocomposite shows higher cell viability at a concentration of 6.5 μg/mL compared to those using individual CNTs. The cell viability and proliferation studies reveal that the toxicity increases with increasing CNTs concentration. The X-ray photoelectron spectroscopy studies have been used to quantify the functional groups present on the CNT–NiO electrode surface before and after proteins functionalization. The bind...

New current-conveyor-based single-resistance-controlled/voltage-controlled oscillator employing grounded capacitors

Abstract: A new current conveyor (CC) based minimum-component oscillator structure has been proposed which provides the following advantageous features over the previously known minimum-component designs: (i) noninteracting control of frequency of oscillation through a single grounded resistor, (ii) easy convertibility into a voltage-controlled oscillator (iii) use of two grounded capacitors as preferred for IC implementation, (iv) availability of a buffered output, and (v) very good frequency stability.

In situ grafted nanostructured ZnO/carboxymethyl cellulose nanocomposites for efficient delivery of curcumin to cancer

Abstract: In this present manuscript, zinc oxide (ZnO) nanoparticles embedded carboxymethyl cellulose (CMC) bionanocomposite were prepared by in situ grafting and the hydrophobic anticancer drug curcumin (Cur) was loaded into it. Structural, morphological, and physiochemical behavior of prepared curcumin-loaded CMC/ZnO nanocomposites (NCs) were characterized by FTIR, XRD, SEM, TEM, TGA, and DTA. The drug entrapment efficiency was evaluated and the in vitro efficacy as anticancer drug delivery vehicle was analyzed. The potential toxicity of curcumin-loaded ZnO/CMC NCs (Cur/ZnO/CMC NCs) was studied by using L929 and MA104 cell lines via MTT assay. The cellular uptake study of Cur/ZnO/CMC NCs by normal (L929) and cancer (MA104) cells carried out by using ethanol extraction and by FACS analysis has been reported. The results of this investigation demonstrate that the nanomatrix synthesized can effectively deliver the anticancer drug curcumin, and hence appears to be a promising nanoformulation for anticancer therapy and other biomedical applications.

Highly sensitive porous carbon and metal/carbon conducting nanofiber based enzymatic biosensors for triglyceride detection

Abstract: Electrospinning was employed to synthesize a Ag nanoparticle (NP)-impregnated partially aligned and free-standing carbon nanofibers (CNFs) mat using a polyacrylonitrile (PAN) and silver nitrate blend followed by carbonization. Pyrolyzation of the PAN/AgNO 3 blend produced the nanoporous CNFs, and the Ag NPs were grown within the CNFs via thermal decomposition of AgNO 3 . The fiber diameters of the synthesized CNFs ranged from 130 to 190 nm, and the size of the impregnated Ag NPs was ∼30 nm. The presence of the Ag NPs enhanced the electrical conductivity and promoted graphitization of the CNFs via the templating effect of the Ag NPs. These synthesized CNFs and AgCNFs nanocomposite were electrophoretically deposited onto indium tin oxide electrodes for detection of triglyceride molecules. Oxygen plasma treatment of the CNFs and AgCNFs surfaces resulted in enhanced loading of lipase and glycerol dehydrogenase bienzymes. The AgCNFs nanocomposite exhibited faster electron transfer than the CNFs, as corroborated by electrochemical impedance spectroscopy and cyclic voltammetry studies. Covalent functionalization via 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide/ N -hydroxysuccinimide coupling chemistry on a nanoporous CNFs surface led to higher stability of the fabricated biosensor toward triglyceride detection. The sensitivity was four-fold higher for the AgCNFs (1.232 μA mg/dL −1 cm −2 ) bioelectrode compared with the CNFs (0.33 μA mg/dL −1 cm −2 ) over a wide detection range (25–500 mg/dL). These biosensors exhibited excellent selectivity, good reproducibility, and faster response (10 s). Thus, enhanced graphitization and electrical conductivity of nanoporous CNFs via incorporation of Ag NPs yields a promising platform for the detection of triglyceride (TG) biomolecules.