Institution
Hiroshima University
Education•Hiroshima, Japan•
About: Hiroshima University is a education organization based out in Hiroshima, Japan. It is known for research contribution in the topics: Population & Cancer. The organization has 33602 authors who have published 69290 publications receiving 1495648 citations. The organization is also known as: Hiroshima Daigaku.
Topics: Population, Cancer, Gene, Catalysis, Transplantation
Papers published on a yearly basis
Papers
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TL;DR: The emergent roles of microRNAs in cartilage homeostasis and OA pathogenesis are summarized in this Review, alongside potential clinical applications.
Abstract: Osteoarthritis (OA), the most common musculoskeletal disorder, is complex, multifaceted, and characterized by degradation of articular cartilage and alterations in other joint tissues. Although some pathogenic pathways have been characterized, current knowledge is incomplete and effective approaches to the prevention or treatment of OA are lacking. Understanding novel molecular mechanisms that are involved in the maintenance and destruction of articular cartilage, including extracellular regulators and intracellular signalling mechanisms in joint cells that control cartilage homeostasis, has the potential to identify new therapeutic targets in OA. MicroRNAs control tissue development and homeostasis by fine-tuning gene expression, with expression patterns specific to tissues and developmental stages, and are increasingly implicated in the pathogenesis of complex diseases such as cancer and cardiovascular disorders. The emergent roles of microRNAs in cartilage homeostasis and OA pathogenesis are summarized in this Review, alongside potential clinical applications.
201 citations
TL;DR: In this article, a central extension of the q-deformed Virasoro algebra which coincides with the usual one in the limit of q → 1 was shown, and the qdeformed operator product expansion which gives the realization of the Q-deformable Virasoria algebra was also shown.
201 citations
TL;DR: In this paper, normal coordinate calculations were performed by the density functional method of B3LYP/6-311+G ∗∗ on 205 basic organic and inorganic compounds taken from the 'Tables of Molecular Vibrational Frequencies' (T. Shimanouchi, 1972).
201 citations
TL;DR: The variable nutrient dynamics that the authors observed among the three study lakes appears to be typical for shallow lake systems, which indicates that a greater reliance on lake-specific research may be required for effective management, and a lesser role of inter-lake generalization than is possible for deeper, dimictic lake systems.
201 citations
TL;DR: The aerobic bacterial flora in the intestine of farmed red and black seabream was investigated at their larval and juvenile stages in relation to the microflora of ambient water and diets.
201 citations
Authors
Showing all 33744 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Tadamitsu Kishimoto | 181 | 1067 | 130860 |
| Takashi Taniguchi | 152 | 2141 | 110658 |
| Yasushi Fukazawa | 135 | 882 | 64424 |
| Itsuo Nakano | 135 | 1539 | 97905 |
| T. Ohsugi | 133 | 664 | 66010 |
| Jerry W. Shay | 133 | 639 | 74774 |
| Tsunefumi Mizuno | 130 | 478 | 60014 |
| Tohru Takeshita | 128 | 1036 | 78625 |
| Alex K.-Y. Jen | 128 | 921 | 61811 |
| Andreas Kugel | 128 | 910 | 75529 |
| Alain Benoit | 124 | 465 | 86284 |
| Hiromitsu Takahashi | 124 | 499 | 55976 |
| Yoshimi Takai | 122 | 680 | 61478 |
| Toshio Hirano | 120 | 401 | 55721 |
| Joakim Nystrand | 117 | 658 | 50146 |