Institution
Hiroshima University
Education•Hiroshima, Japan•
About: Hiroshima University is a education organization based out in Hiroshima, Japan. It is known for research contribution in the topics: Population & Cancer. The organization has 33602 authors who have published 69290 publications receiving 1495648 citations. The organization is also known as: Hiroshima Daigaku.
Topics: Population, Cancer, Gene, Catalysis, Transplantation
Papers published on a yearly basis
Papers
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TL;DR: These results indicate that beta-defensins and LL37 have versatile antibacterial activity against oral bacteria.
Abstract: The oral cavity is a unique environment in which antimicrobial peptides play a key role in maintaining health and may have future therapeutic applications. Present evidence suggests that α-defensins, β-defensins, LL-37, histatin, and other antimicrobial peptides and proteins have distinct but overlapping roles in maintaining oral health and preventing bacterial, fungal, and viral adherence and infection. The expression of the inducible hBD-2 in normal oral epithelium, in contrast to other epithelia, and the apparent differential signaling in response to commensal and pathogenic organisms, provides new insights into innate immunity in this body site. Commensal bacteria are excellent inducers of hBD-2 in oral epithelial cells, suggesting that the commensal bacterial community acts in a manner to benefit the overall innate immune readiness of oral epithelia. This may have major significance for understanding host defense in the complex oral environment.
406 citations
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TL;DR: Radon concentration in ground water increased for several months before the 1995 southern Hyogo Prefecture (Kobe) earthquake on 17 January 1995, and reached a peak of more than 10 times that at the beginning of the observation, before starting to decrease.
Abstract: Radon concentration in ground water increased for several months before the 1995 southern Hyogo Prefecture (Kobe) earthquake on 17 January 1995. From late October 1994, the beginning of the observation, to the end of December 1994, radon concentration increased about fourfold. On 8 January, 9 days before the earthquake, the radon concentration reached a peak of more than 10 times that at the beginning of the observation, before starting to decrease. These radon changes are likely to be precursory phenomena of the disastrous earthquake.
404 citations
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TL;DR: Evidence is presented that IL-6 increases TJ permeability by stimulating the expression of channel-forming claudin-2, which is required for increased caudal-related homeobox (Cdx) 2 through the MEK/ERK and PI3K pathways in intestinal epithelial cells.
402 citations
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Nagoya University1, Japan Aerospace Exploration Agency2, Auburn University3, University of Aizu4, Kobe University5, University of Tokyo6, Graduate University for Advanced Studies7, Hiroshima University8, Tohoku University9, Chiba Institute of Technology10, Kindai University11, National Institute of Advanced Industrial Science and Technology12, Kōchi University13, Rikkyo University14, National Institute of Information and Communications Technology15, Seoul National University16, Planetary Science Institute17, Johns Hopkins University Applied Physics Laboratory18, Centre national de la recherche scientifique19, University of Colorado Boulder20, Meiji University21, German Aerospace Center22, Centre National D'Etudes Spatiales23
TL;DR: The Hayabusa2 spacecraft measured the mass, size, shape, density, and spin rate of asteroid Ryugu, showing that it is a porous rubble pile, and observations of Ryugu's shape, mass, and geomorphology suggest that Ryugu was reshaped by centrifugally induced deformation during a period of rapid rotation.
Abstract: The Hayabusa2 spacecraft arrived at the near-Earth carbonaceous asteroid 162173 Ryugu in 2018. We present Hayabusa2 observations of Ryugu’s shape, mass, and geomorphology. Ryugu has an oblate “spinning top” shape, with a prominent circular equatorial ridge. Its bulk density, 1.19 ± 0.02 grams per cubic centimeter, indicates a high-porosity (>50%) interior. Large surface boulders suggest a rubble-pile structure. Surface slope analysis shows Ryugu’s shape may have been produced from having once spun at twice the current rate. Coupled with the observed global material homogeneity, this suggests that Ryugu was reshaped by centrifugally induced deformation during a period of rapid rotation. From these remote-sensing investigations, we identified a suitable sample collection site on the equatorial ridge.
402 citations
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TL;DR: It is demonstrated that the DIX domain of DVL2 mediates dynamic polymerization, which is essential for the signaling activity of Dvl2, the purified domain of which polymerizes gradually, reversibly and in a concentration dependent manner, ultimately forming fibrils.
Abstract: The Wnt signaling pathway controls numerous cell fates in animal development and is also a major cancer pathway. Dishevelled (Dvl) transduces the Wnt signal by interacting with the cytoplasmic Axin complex. Dvl and Axin each contain a DIX domain whose molecular properties and structure are unknown. Here, we demonstrate that the DIX domain of Dvl2 mediates dynamic polymerization, which is essential for the signaling activity of Dvl2. The purified domain polymerizes gradually, reversibly and in a concentration dependent manner, ultimately forming fibrils. The Axin DIX domain has a novel structural fold largely composed of β-strands that engage in head-to-tail self-interaction to form filaments in the crystal. The DIX domain thus seems to mediate the formation of a dynamic interaction platform with a high local concentration of binding sites for transient Wnt signaling partners; this represents a previously uncharacterized mechanistic principle, signaling by reversible polymerization.
402 citations
Authors
Showing all 33744 results
Name | H-index | Papers | Citations |
---|---|---|---|
Tadamitsu Kishimoto | 181 | 1067 | 130860 |
Takashi Taniguchi | 152 | 2141 | 110658 |
Yasushi Fukazawa | 135 | 882 | 64424 |
Itsuo Nakano | 135 | 1539 | 97905 |
T. Ohsugi | 133 | 664 | 66010 |
Jerry W. Shay | 133 | 639 | 74774 |
Tsunefumi Mizuno | 130 | 478 | 60014 |
Tohru Takeshita | 128 | 1036 | 78625 |
Alex K.-Y. Jen | 128 | 921 | 61811 |
Andreas Kugel | 128 | 910 | 75529 |
Alain Benoit | 124 | 465 | 86284 |
Hiromitsu Takahashi | 124 | 499 | 55976 |
Yoshimi Takai | 122 | 680 | 61478 |
Toshio Hirano | 120 | 401 | 55721 |
Joakim Nystrand | 117 | 658 | 50146 |