Institution
Hiroshima University
Education•Hiroshima, Japan•
About: Hiroshima University is a education organization based out in Hiroshima, Japan. It is known for research contribution in the topics: Population & Cancer. The organization has 33602 authors who have published 69290 publications receiving 1495648 citations. The organization is also known as: Hiroshima Daigaku.
Topics: Population, Cancer, Gene, Catalysis, Transplantation
Papers published on a yearly basis
Papers
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TL;DR: This review summarizes the major achievements of the project in newly found superconducting materials, and the fabrication wires and tapes of iron-based superconductors; it incorporates a list of ∼700 unsuccessful materials examined for superconductivity in the project.
311 citations
TL;DR: Overexpression of bovine GAP suppressed the phenotypes of ira mutants by reducing the level of RAS-GTP, suggesting that IRA proteins may be functionally analogous to mammalian GAP.
311 citations
TL;DR: In this paper, spc-Ni/MgAl catalysts were used for the partial oxidation of CH 4 into synthesis gas, and the surface area of spcNi 0.5 /Mg 2.5 Al catalysts was around 150m 2 ǫg cat −1.
310 citations
Journal Article•
TL;DR: It is reported that forced exogenous overexpression of AIM-1 in Chinese hamster embryo cells causes increased mitotic Ser-10 phosphorylation with concomitant induction of lagging chromosomes during mitosis, which suggests that increased H3 histone phosphorylated as a result of A IM-1 overeexpression is a major precipitating factor of chromosome instability and, thus, may play a role in carcinogenesis.
Abstract: Phosphorylation of histone H3 at Ser-10 is required for maintenance of properchromosome dynamics during mitosis. AIM-1, a mammalian Ipl1/aurora kinase involved in H3 phosphorylation, is transcriptionally overexpressed in many tumor cell lines. Increased expression of the AIM-1 gene has been observed in human colorectal tumors of advanced grade and stage. Here we report that forced exogenous overexpression of AIM-1 in Chinese hamster embryo cells causes increased mitotic Ser-10 phosphorylation with concomitant induction of lagging chromosomes during mitosis. Lagging chromosomes could also be induced by transfection with mutated histone H3 (S10E), which is thought to maintain Ser-10 in the phosphorylated state. In the present study, chromosome number instability and increased tumor invasiveness were noted in constitutively AIM-1-overexpressing cells in vivo. Increased mitotic Ser-10 phosphorylation was also observed in various colorectal tumor cells with high AIM-1 expression levels. These data suggest that increased H3 histone phosphorylation as a result of AIM-1 overexpression is a major precipitating factor of chromosome instability and, thus, may play a role in carcinogenesis.
309 citations
TL;DR: There was no difference in almost any postoperative measure of intraoperative and postoperative complication in segmentectomy and lobectomy patients, except more air leakage was observed in the segmentectomy arm.
309 citations
Authors
Showing all 33744 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Tadamitsu Kishimoto | 181 | 1067 | 130860 |
| Takashi Taniguchi | 152 | 2141 | 110658 |
| Yasushi Fukazawa | 135 | 882 | 64424 |
| Itsuo Nakano | 135 | 1539 | 97905 |
| T. Ohsugi | 133 | 664 | 66010 |
| Jerry W. Shay | 133 | 639 | 74774 |
| Tsunefumi Mizuno | 130 | 478 | 60014 |
| Tohru Takeshita | 128 | 1036 | 78625 |
| Alex K.-Y. Jen | 128 | 921 | 61811 |
| Andreas Kugel | 128 | 910 | 75529 |
| Alain Benoit | 124 | 465 | 86284 |
| Hiromitsu Takahashi | 124 | 499 | 55976 |
| Yoshimi Takai | 122 | 680 | 61478 |
| Toshio Hirano | 120 | 401 | 55721 |
| Joakim Nystrand | 117 | 658 | 50146 |