Institution
Hungarian Academy of Sciences
Government•Budapest, Hungary•
About: Hungarian Academy of Sciences is a government organization based out in Budapest, Hungary. It is known for research contribution in the topics: Catalysis & Population. The organization has 21510 authors who have published 56712 publications receiving 1612286 citations. The organization is also known as: Magyar Tudományos Akadémia & MTA.
Topics: Catalysis, Population, Adsorption, Ion, Gene
Papers published on a yearly basis
Papers
More filters
••
TL;DR: In this article, the authors measured charged-particle pseudo-rapidity density at the LHC with the ALICE detector at centre-of-mass energies 0.9 TeV and 2.36 TeV in the pseudorapidity range.
Abstract: Charged-particle production was studied in proton-proton collisions collected at the LHC with the ALICE detector at centre-of-mass energies 0.9 TeV and 2.36 TeV in the pseudorapidity range vertical bar eta vertical bar < 1.4. In the central region (vertical bar eta vertical bar < 0.5), at 0.9 TeV, we measure charged-particle pseudo-rapidity density dN(ch)/d eta = 3.02 +/- 0.01(stat.)(-0.05)(+0.08)(syst.) for inelastic interactions, and dN(ch)/d eta = 3.58 +/- 0.01 (stat.)(-0.12)(+0.12)(syst.) for non-single-diffractive interactions. At 2.36 TeV, we find dN(ch)/d eta = 3.77 +/- 0.01(stat.)(-0.12)(+0.25)(syst.) for inelastic, and dN(ch)/d eta = 4.43 +/- 0.01(stat.)(-0.12)(+0.17)(syst.) for non-single-diffractive collisions. The relative increase in charged-particle multiplicity from the lower to higher energy is 24.7% +/- 0.5%(stat.)(-2.8)(+5.7)%(syst.) for inelastic and 23.7% +/- 0.5%(stat.)(-1.1)(+4.6)%(syst.) for non-single-diffractive interactions. This increase is consistent with that reported by the CMS collaboration for non-single-diffractive events and larger than that found by a number of commonly used models. The multiplicity distribution was measured in different pseudorapidity intervals and studied in terms of KNO variables at both energies. The results are compared to proton-antiproton data and to model predictions.
284 citations
••
TL;DR: In this paper, the authors propose to calculate interatomic overlap populations, bond order indices and actual atomic valences from the results of ab initio quantum chemical calculations, in terms of "fuzzy" atoms, i.e., such divisions of the three-dimensional physical space into atomic regions in which the regions assigned to the individual atoms have no sharp boundaries but exhibit a continuous transition from one to another.
283 citations
••
TL;DR: In this paper, the characteristics of the adsorption and reactions of CO 2 on Rh, Pd, Pt, Ni, Fe, Cu, Re, Al, Mg and Ag metals are discussed with particular emphasis on the activation of the CO 2 molecule.
283 citations
••
TL;DR: The use of multiphase, multicomponent materials is expected to grow with a larger than average rate also in the future as mentioned in this paper, and it is important to keep the interdisciplinary nature of the area since principles and techniques developed by one field may find application also in other areas.
283 citations
••
TL;DR: An intact cannabinoid signaling pathway is necessary for the stimulatory effects of gh Relin on AMPK activity and food intake, and for the inhibitory effect of ghrelin on paraventricular neurons.
Abstract: INTRODUCTION: Ghrelin and cannabinoids stimulate appetite, this effect possibly being mediated by the activation of hypothalamic AMP-activated protein kinase (AMPK), a key enzyme in appetite and metabolism regulation. The cannabinoid receptor type 1 (CB1) antagonist rimonabant can block the orexigenic effect of ghrelin. In this study, we have elucidated the mechanism of the putative ghrelin-cannabinoid interaction. METHODS: The effects of ghrelin and CB1 antagonist rimonabant in wild-type mice, and the effect of ghrelin in CB1-knockout animals, were studied on food intake, hypothalamic AMPK activity and endogenous cannabinoid content. In patch-clamp electrophysiology experiments the effect of ghrelin was assessed on the synaptic inputs in parvocellular neurons of the hypothalamic paraventricular nucleus, with or without the pre-administration of a CB1 antagonist or of cannabinoid synthesis inhibitors. RESULTS AND CONCLUSIONS: Ghrelin did not induce an orexigenic effect in CB1-knockout mice. Correspondingly, both the genetic lack of CB1 and the pharmacological blockade of CB1 inhibited the effect of ghrelin on AMPK activity. Ghrelin increased the endocannabinoid content of the hypothalamus in wild-type mice and this effect was abolished by rimonabant pre-treatment, while no effect was observed in CB1-KO animals. Electrophysiology studies showed that ghrelin can inhibit the excitatory inputs on the parvocellular neurons of the paraventricular nucleus, and that this effect is abolished by administration of a CB1 antagonist or an inhibitor of the DAG lipase, the enzyme responsible for 2-AG synthesis. The effect is also lost in the presence of BAPTA, an intracellular calcium chelator, which inhibits endocannabinoid synthesis in the recorded parvocellular neuron and therefore blocks the retrograde signaling exerted by endocannabinoids. In summary, an intact cannabinoid signaling pathway is necessary for the stimulatory effects of ghrelin on AMPK activity and food intake, and for the inhibitory effect of ghrelin on paraventricular neurons.
283 citations
Authors
Showing all 21526 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jasvinder A. Singh | 176 | 2382 | 223370 |
Alexander S. Szalay | 166 | 936 | 145745 |
Ashok Kumar | 151 | 5654 | 164086 |
György Buzsáki | 150 | 446 | 96433 |
Daniel Bloch | 145 | 1819 | 119556 |
Brajesh C Choudhary | 143 | 1618 | 108058 |
Geoffrey Burnstock | 141 | 1488 | 99525 |
Suman Bala Beri | 137 | 1608 | 104798 |
Vipin Bhatnagar | 137 | 1756 | 104163 |
Paul Slovic | 136 | 506 | 126658 |
Manjit Kaur | 135 | 1540 | 97378 |
Gabor Istvan Veres | 135 | 1349 | 96104 |
Dimitri Bourilkov | 134 | 1489 | 96884 |
Georges Azuelos | 134 | 1294 | 90690 |
Michael Tytgat | 134 | 1449 | 94133 |