Jessore University of Science & Technology

About: Jessore University of Science & Technology is a based out in . It is known for research contribution in the topics: Adsorption & Population. The organization has 811 authors who have published 974 publications receiving 10471 citations.

Epitope-based chimeric peptide vaccine design against S, M and E proteins of SARS-CoV-2 etiologic agent of global pandemic COVID-19: an in silico approach

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing pandemic of coronavirus disease 2019 (COVID-19), a public health emergency of international concern declared by the World Health Organization (WHO). An immuno-informatics approach along with comparative genomic was applied to design a multi-epitope-based peptide vaccine against SARS-CoV-2 combining the antigenic epitopes of the S, M and E proteins. The tertiary structure was predicted, refined and validated using advanced bioinformatics tools. The candidate vaccine showed an average of ≥ 90.0% world population coverage for different ethnic groups. Molecular docking of the chimeric vaccine peptide with the immune receptors (TLR3 and TLR4) predicted efficient binding. Immune simulation predicted significant primary immune response with increased IgM and secondary immune response with high levels of both IgG1 and IgG2. It also increased the proliferation of T-helper cells and cytotoxic T-cells along with the increased INF-γ and IL-2 cytokines. The codon optimization and mRNA secondary structure prediction revealed the chimera is suitable for high-level expression and cloning. Overall, the constructed recombinant chimeric vaccine candidate demonstrated significant potential and can be considered for clinical validation to fight against this global threat, COVID-19.

Microalgal Pigments: A Source of Natural Food Colors

Abstract: Naturally sourced colorants and dyes are currently gaining demand over synthetic alternatives due to an increase in consumer awareness brought forward by health and environmental issues. Microalgae are unicellular organisms which are microscopic in size and represent major photosynthesizers with the ability to efficiently convert available solar energy to chemical energy. Due to their distinct advantages over terrestrial plants such as faster growth rates, ability to grow on non-arable land, and diversity in the production of various natural bioactive compounds (e.g., lipids, proteins, carbohydrate, and pigments), microalgae are currently gaining promise as a sustainable source for the production of natural food-grade colorants. The versatility of microalgae to produce various pigments (e.g., chlorophylls, carotenoids, xanthophylls, and phycobiliproteins) that can be commercially exploited as a source of natural colorant is there to be explored. Various growth factors such as temperature, pH, salinity, and light in terms of both quality and quantity have been shown to significantly impact pigment production. In this chapter, we comprehensively review the characteristics of microalgal pigments and factors that affect pigment production in microalgae while evaluating the overall feasibility of exploiting them as a natural source of food colorants.

Nano-layered surface plasmon resonance-based highly sensitive biosensor for virus detection: A theoretical approach to detect SARS-CoV-2

Abstract: The outbreak of the coronavirus disease (COVID-19) pandemic has become a worldwide health catastrophe instigated by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Countries are battling to slow the spread of this virus by testing and treating patients, along with other measures such as prohibiting large gatherings, maintaining social distance, and frequent, thorough hand washing, as no vaccines or medicines are available that could effectively treat infected people for different types of SARS-CoV-2 variants. However, the testing procedure to detect this virus is lengthy. This study proposes a surface plasmon resonance-based biosensor for fast detection of SARS-CoV-2. The sensor employs a multilayered configuration consisting of TiO2–Ag–MoSe2 graphene with a BK7 prism. Antigen–antibody interaction was considered the principle for this virus detection. Immobilized CR3022 antibody molecules for detecting SARS-CoV-2 antigens (S-glycoprotein) are used for this sensor. It was found that the proposed sensor’s sensitivity (194°/RIU), quality factor (54.0390 RIU−1), and detection accuracy (0.2702) outperformed those of other single and multilayered structures. This study could be used as a theoretical base and primary step in constructing an actual sensor.

Prospect of Pongamia pinnata (Karanja) in Bangladesh: A Sustainable Source of Liquid Fuel

Abstract: Energy is the basic requirement for the existence of human being in today’s digital world. Indigenous energy of Bangladesh (especially natural gas and diesel) is basically used in power generation and depleting hastily to meet the increasing power demand. Therefore, special emphasis has been given to produce alternative liquid fuel worldwide to overcome the crisis of diesel. Pongamia pinnata (karanja) may be an emerging option for providing biooil for biodiesel production. Although karanja biooil has been used as a source of traditional medicines in Bangladesh, it can also be used for rural illumination. This paper outlines the medical and energy aspects of Pongamia pinnata. It has been assessed that Bangladesh can utilize about 128.95 PJ through Pongamia cultivation in unused lands. The paper reviews the potentiality of Pongamia pinnata as a source of biodiesel and its benefits in Bangladesh. The paper also revives that, about 0.52 million tons of biodiesel can be produced only utilizing the unused lands per year in sustainable basis as it reduces CO2, CO, HC, and NOx emission compared to pure diesel.