Liaoning University of Traditional Chinese Medicine

About: Liaoning University of Traditional Chinese Medicine is a education organization based out in Shenyang, China. It is known for research contribution in the topics: Randomized controlled trial & Acupuncture. The organization has 2040 authors who have published 1326 publications receiving 14664 citations.

Transplantation of Stem Cells from Human Exfoliated Deciduous Teeth Decreases Cognitive Impairment from Chronic Cerebral Ischemia by Reducing Neuronal Apoptosis in Rats.

Abstract: Stem cells from human exfoliated deciduous teeth (SHED) are a unique postnatal stem cell population with high self-renewal ability that originates from the cranial neural crest. Since SHED are homologous to the central nervous system, they possess superior capacity to differentiate into neural cells. However, whether and how SHED ameliorate degenerative central nervous disease are unclear. Chronic cerebral ischemia (CCI) is a kind of neurological disease caused by long-term cerebral circulation insufficiency and is characterized by progressive cognitive and behavioral deterioration. In this study, we showed that either systemic transplantation of SHED or SHED infusion into the hippocampus ameliorated cognitive impairment of CCI rats in four weeks after SHED treatment by rescuing the number of neurons in the hippocampus area. Mechanistically, SHED transplantation decreased the apoptosis of neuronal cells in the hippocampus area of CCI rats through downregulation of cleaved caspase-3. In summary, SHED transplantation protected the neuronal function and reduced neuronal apoptosis, resulting in amelioration of cognitive impairment from CCI. Our findings suggest that SHED are a promising stem cell source for cell therapy of neurological diseases in the clinic.

Isoimperatorin exerts anti-inflammatory activity by targeting the LPS-TLR4/MD-2-NF-κB pathway:

Abstract: Isoimperatorin (QHS) is a phytoconstituent found in the methanolic extracts obtained from the roots of Angelica dahurica, which contains anti-inflammatory, anti-bacterial, analgesic, anti-tumor, an...

Biotransformation of ginsenoside using covalently immobilized snailase enzyme onto activated carrageenan gel beads

Abstract: Ginsenoside transformation has received significant attention from scientists. The main objective of this study is to use immobilized enzymes in ginsenoside transformation. Factors affecting immobilization process were studied; carrageenan beads treated with polyethyleneimine and then activated using glutaraldehyde (GA) were used for snailase enzyme immobilization. The functionalized gel beads were characterized using Fourier transform infrared spectroscopy to verify the modification process. Furthermore, the optimum conditions for biotransformation of ginsenoside were also deliberated and showed that optimum biotransformation pH is 4.5 and 5–5.5 and temperature 50 and $$60^{\circ }\hbox {C}$$ for free and immobilized snailase, respectively. Michaelis constants, $$K_{\mathrm{m}}$$ and $$V_{\max }$$ , were also studied. The immobilized enzyme retains 96% of its initial activity after being used 10 consecutive times. The results clearly suggested that ginsenoside transformation was performed using immobilized snailase; this process can reduce the transformation cost as the enzyme can be reused many times.

[Treatment of chronic heart failure by shencao tongmai granule: a multi-centered, double-blinded, randomized, parallel controlled trial].

Abstract: Objective To assess the clinical effects and safety of Shencao Tongmai Granule(STG)in treatment of patients with chronic heart failure(CHF)(NYHA functional class Ⅱ-Ⅲ)of qi deficiency blood stasis and water retention syndrome(QDBSWRS).Methods This was a multi-centered,double blinded,randomized,and placebo parallel controlled study.A total of 280 CHF patients of QDBSWRS were randomly assigned to the trial group and the control group in the ratio of 1:1.All patients received Western medicine(WM)treatment such as ACEI,diuretics,Digoxin Elixirs,and so on.Additionally,patients in the trial group took STG while those in the control group took the placebo.The therapeutic course for all was twelve weeks.The NYHA functional classification,Chinese medicine(CM)syndrome integral,and left ventricular ejection fraction(LVEF)were compared between the two groups.The safety assessment was also carried out.Results Totally 265 patients completed this trial(138 cases in the trial group and 127 cases in the control group).The effective rate of NYHA functional classification and CM syndrome integral were obviously higher in the trial group than in the control group(94.20% vs 55.90%,97.83% vs 70.08% respectively),showing statistical difference(P0.01).There was no statistical difference in LVEF between the two groups before treatment(P0.05).The LVEF both increased in the two groups when compared with before treatment(P0.05).The post-treatment increment of LVEF was obviously higher in the trial group than in the control group(6.55%±6.23% vs 3.14%±4.99%,P0.05).The rate of adverse reaction was 0.71% in the two groups(1/140).Conclusion STG showed good therapeutic effectiveness and safety in treating CHF patients of QDBSWRS.

Effect of herb-partitioned moxibustion for primary dysmenorrhea: a randomized clinical trial.

Abstract: OBJECTIVE To observe the effect of herb-partitioned moxibustion (HPM) for primary dysmenorrhea. METHODS Six hundred and forty patients were randomized assigned (1∶1) to HPM group and control group. Duration of treatment was 3 months with 3 month follow-up. The primary outcome was pain relief measured by visual analogue scale (VAS). The second outcomes were Cox Menstrual Symptom Scale (CMSS), menstrual pain duration and frequency of analgesics usage. The exploratory outcome included quality of life, RESULTS: After the 3-month treatment and follow-ups, the pain intensity measured by VAS was significantly reduced in both groups compared with baseline (P < 0.05), and it was significantly decreased in HPM group than that of control group (P < 0.001). The higher proportion of participants in the HPM group had a decrease of at least 50% in VAS at the end of treatment, as compared with the control group (P < 0.001). At the 3rd and 6th month, the menstrual pain duration, CMSS score and frequency of analgesics usage in HPM group were significantly lower than those of control group (P < 0.05). After 3 month treatment and follow-ups,the scores of physical, psychological, social and environmental domains were significantly increased than baseline in both groups (P < 0.05), and the sores of physical, psychological and environmental domains were significantly higher in HPM group than those of control group (P < 0.05) . CONCLUSION Herb-partitioned moxibustion reduced menstrual pain and improved quality of life, these were sustained for up to 3 months after treatment. Further research is needed to understand long term effect and the mechanism of the intervention.