Liaoning University of Traditional Chinese Medicine

About: Liaoning University of Traditional Chinese Medicine is a education organization based out in Shenyang, China. It is known for research contribution in the topics: Randomized controlled trial & Acupuncture. The organization has 2040 authors who have published 1326 publications receiving 14664 citations.

Cannabisin D from Sinomenium Acutum Inhibits Proliferation and Migration of Glioblastoma Cells through MAPKs Signaling.

Abstract: Glioblastoma is the most common and malignant tumor in human central nervous system with poor prognosis. From the dried stem of Sinomenium acutum, an herbal medicine, five compounds (sinomenine, syringin, corchoionoside C, protocatechuic acid and cannabisin D) were isolated, characterized and subjected to cytotoxicity screening on U-87 and U-251 glioblastoma cells. Cannabisin D presented effective inhibitory effects on the proliferation and migration of glioblastoma cells. By flow cytometry, real-time PCR and Western blotting, cell apoptosis and cell cycle arrest were proved to contribute to the anti-glioblastoma effects. Further, the activation of MAPKs signaling (p38 MAPK, p42/p44 MAPK and SAPK/JNK) was observed in glioblastoma cells upon cannabisin D treatment by Western blotting, indicating the involvement of MAPKs signaling in the inhibitory effects of cannabisin D. These data suggested that S. acutum is a novel natural source of cannabisin D and cannabisin D is a novel anti-glioblastoma agent candidate.

The complete mitochondrial genome of Arctium lappa (Campanulales, Asteraceae)

Abstract: Complete mitogenome sequence of an important medicinal plant, Arctium lappa, was determined for the first time. The entire circular genome is 312,598 bp in length (GenBank accession number SRX75654...

[Effect of Electroacupuncture on Hypothalamus-Pituitary-Ovary (HPO) Axis in Rats with Peri-menopausal Depression].

Abstract: OBJECTIVE To observe the effect of electroacupuncture (EA) on the hormones derived from the hypothalamus-pituitary-ovary (HPO) axis, so as to explore the neuroendocrine mechanism induced by EA on rats with perimenopausal depression disorder. METHODS Sixty female sprague-dawley rats were randomly divided into blank control group, model group, sham-operation (sham) group, clomipramine group, and electroacupuncture (EA) group, with 12 rats in each group. Perimenopausal depression model was established by bilateral ovariectomy combined with chronic unpredictable stimulation.The EA group received continuous treatment at "Baihui" (GV 20), "Shenshu" (BL 23) and "Sanyinjiao" (SP 6) once a day for 28 days. Estrous cycle and sucrose preference test were monitored, and serum estradiol (E2), luteinizing hormone (LH), gonadotropin releasing hormone (GnRH), and β-endorphin (β-EP) were detected by ELISA. RESULTS Compared to the blank control group, sugar water consumpution rates decreased in the model group and sham group (P<0.05). Compared to the blank group and sham group, the serum LH and GnRH levels increased (P<0.05), companied with lower serum E2 and β-EP levels in the model group (P<0.05). Compared to the model group, sugar water consumpution rates increased in the clomipramine group and EA group (P<0.05), both were companied with decreased serum LH and GnRH levels (P<0.05), and higher serum E2 and β-EP levels (P<0.05). CONCLUSIONS Electroacupuncture can relieve the symptoms of rat with perimenopausal depression by regulating the hormone secretion in HPO axis.

Development of health behaviour questionnaire for breast cancer women in Mainland China.

Abstract: Aim To develop a questionnaire on the health behaviour of breast cancer women with adjuvant endocrine therapy and to test its reliability and validity. Design An instrument-development study was applied that comprised three steps: conceptualization, item generation, content validity and field testing of the health behavior properties. Methods On the basis of literature review, the conceptual framework and initial items of each dimension of were designed. The questionnaire investigation was divided into two steps: pre-experiment (group 1) and psychometrics evaluation (group 2). Correlation procedure and factor analysis were employed to rescreen the items. Reliability testing and validity testing were conducted to analyse the psychometric properties of questionnaire. Results Exploratory and confirmatory factor analyses yielded a five-factor solution. Cronbach's α was 0.93, the sub-semi-reliability of the questionnaire was 0.79 and internal consistency coefficients was 0.70.

Efficient water-mediated synthesis of bismuth oxyiodide with several distinct morphologies

Abstract: It is highly desirable to synthesize various micro/nanostructures of bismuth oxyhalides by facile methods and to further investigate these functional photoactive materials. Herein, we demonstrate a facile route to synthesize five distinct morphologies of BiOI microstructures via the solvothermal method. Notably, based on the morphology study of the intermediate products and the crystal structure analysis of the BiOI microstructures, the mechanism by which water modulates the crystal growth and finally mediates the morphology of BiOI microstructures was proposed. It is demonstrated that water can control the crystal growth, and increasing the amount of water can transform the growth from vertical to the (001) facets to parallel to them. By combining Ostwald ripening crystal reconstruction and self-assembly of nanostructures, the microstructures of BiOI can be precisely controlled. Therefore, the water-mediated strategy not only gives a new route for specific BiOI microstructure preparation but also provides new evidence for further understanding of the crystal growth mechanism of BiOI prepared by the wet-chemical method.