Institution
Liaoning University of Traditional Chinese Medicine
Education•Shenyang, China•
About: Liaoning University of Traditional Chinese Medicine is a education organization based out in Shenyang, China. It is known for research contribution in the topics: Randomized controlled trial & Acupuncture. The organization has 2040 authors who have published 1326 publications receiving 14664 citations.
Topics: Randomized controlled trial, Acupuncture, Apoptosis, Cancer, Portulaca
Papers published on a yearly basis
Papers
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TL;DR: It is reported that selective breakage of two conserved disulfide bonds located at the knees of integrin activated integrin and had a unique structure that was different from the typical extended conformation of active integrin.
Abstract: Control of integrin activation and signaling plays crucial roles in cell adhesion, spreading and migration. Here, we report that selective breakage of two conserved disulfide bonds located at the knees of integrin alpha(4)C589-C594 and beta(7)C494-C526 activated alpha(4)beta(7). This activated integrin had a unique structure that was different from the typical extended conformation of active integrin. In addition, these activated alpha(4)beta(7) integrins spontaneously clustered on the cell membrane and triggered integrin downstream signaling independent of ligand binding. Although these disulfide bonds were not broken during alpha(4)beta(7) activation by inside-out signaling or Mn2+, they could be specifically reduced by 0.1 mM dithiothreitol, a reducing strength that could be produced in vivo under certain conditions. Our findings reveal a novel mechanism of integrin activation under specific reducing conditions by which integrin can signal and promote cell spreading in the absence of ligand.
9 citations
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TL;DR: The systematic evaluation of LDXGT for the treatment of insomnia showed the relative benefits in effective rates compared with conventional western medicine, and the side effects of western medicine are addressed.
9 citations
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TL;DR: Wang et al. as discussed by the authors combined ultrahigh-performance liquid chromatography quadrupole-Orbitrap high-resolution mass spectrometry (UHPLC-Q-ORbitrap-HRMS), network pharmacology and experiments was carried out to investigate the potential materials and pharmacological mechanisms of Danggui-Shaoyao-San (DSS) for AS.
9 citations
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TL;DR: In this article, a simple scheme of using berberine (BBR) to modify porous calcium phosphate ceramics (named PCPC) was proposed, which significantly improved the bone regeneration of osteoporosis rats.
Abstract: In this article, we propose a simple scheme of using berberine (BBR) to modify porous calcium phosphate ceramics (named PCPC). These BBR molecules regulate the crystallization of hydroxyapatite nanorods on PCPC. We found that these nanorods and the adsorbed BBR changed the interface micro-environment of PCPC by SEM images. The microenvironment of PCPC surface is essential for promoting BMSCs' proliferation and differentiation. These results demonstrated that PCPC/BBR markedly improved the bone regeneration of osteoporosis rats. Moreover, PCPC/BBR had significantly increased the expression levels of ALP, osteocalcin and bone morphogenetic protein2 and RUNX2 in BMSCs originated from osteoporosis rats.
9 citations
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TL;DR: Gene polymorphisms of PPARA, SLCO1B1 and NFKB1 affected the pharmacokinetics of lovastatin, particularly in Chinese healthy subjects.
Abstract: Aim: This study examined whether gene polymorphisms (CYP3A4, ABCG2, SLCO1B1, NR1I2, PPARA and NFKB1) influenced the pharmacokinetics of lovastatin in Chinese healthy subjects. Patients & method: Plasma concentrations of lovastatin and lovastatin acid were quantified using LC/MS/MS. Results: PPARA c.208+3819 G allele carriers had approximately twofold higher AUC0-∞ and Cmax of lovastatin than wild-type (PPARA c.208+3819 AA) subjects. After adjustment for the PPARA variants, subjects with the SLCO1B1 521TT genotype had approximately 50% lower AUC0-∞ of lovastatin acid than those with 521TC/CC genotypes, while the AUC0-∞ of lovastatin lactone in NFKB1-94 DD wild-type carriers was twofold higher than in mutant homozygotes carriers. Conclusion: Gene polymorphisms of PPARA, SLCO1B1 and NFKB1 affected the pharmacokinetics of lovastatin.
9 citations
Authors
Showing all 2045 results
Name | H-index | Papers | Citations |
---|---|---|---|
Hang Xiao | 64 | 618 | 16026 |
Muhammad Riaz | 58 | 934 | 15927 |
Jianping Liu | 45 | 333 | 7977 |
Guoan Luo | 45 | 221 | 6358 |
Xingshun Qi | 40 | 308 | 5409 |
Mei Wang | 29 | 201 | 6007 |
Xiaozhong Guo | 28 | 142 | 2269 |
Zhiwei Cao | 27 | 110 | 2879 |
Xinggang Yang | 26 | 113 | 2292 |
Ruixin Zhu | 25 | 110 | 2119 |
Ran Wang | 23 | 157 | 1942 |
Li-Ping Bai | 22 | 95 | 1824 |
Ke Liu | 19 | 31 | 1183 |
Ahmed M. Metwaly | 17 | 51 | 682 |
Kailin Tang | 17 | 40 | 919 |