Institution
Liaoning University of Traditional Chinese Medicine
Education•Shenyang, China•
About: Liaoning University of Traditional Chinese Medicine is a education organization based out in Shenyang, China. It is known for research contribution in the topics: Randomized controlled trial & Acupuncture. The organization has 2040 authors who have published 1326 publications receiving 14664 citations.
Topics: Randomized controlled trial, Acupuncture, Apoptosis, Cancer, Portulaca
Papers published on a yearly basis
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University of Cagliari1, Sapienza University of Rome2, Innsbruck Medical University3, Harvard University4, University of Texas MD Anderson Cancer Center5, Dresden University of Technology6, University of Eastern Piedmont7, University of Pavia8, University of Freiburg9, Casa Sollievo della Sofferenza10, University of Rome Tor Vergata11, University of Bari12, Liaoning University of Traditional Chinese Medicine13
TL;DR: Physicians most frequently tended to overestimate health status of patients who reported low-level health status and the value of decision aid-tools in the challenging setting of higher-risk MDS should be investigated to further promote patient-centered care.
16 citations
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TL;DR: In this article, the authors investigated the role of circHIPK2 in ovarian cancer resistance to Cisplatin and showed that it is associated with DDP resistance and decreased B cell lymphoma (Bcl)-2, matrix metalloproteinase 2 (MMP2) and MMP9 levels.
Abstract: Background Cisplatin (DDP) is standard-of-care and first-line management for ovarian cancer (OvCa). Circular RNA HIPK2 (circHIPK2) is abnormally upregulated in serum of OvCa patients. However, its role in DDP resistance remains unclear. Methods Expression of cirHIPK2, microRNA (miR)-338-3p and chromatin target of protein arginine methyltransferase (CHTOP) was detected by quantitative reverse transcription PCR and Western blotting. Functional experiments were performed using cell counting kit-8 assay, flow cytometry, transwell assays, Western blotting, and xenograft experiment. The interaction among cirHIPK2, miR-338-3p and CHTOP was confirmed by dual-luciferase reporter assay and RNA pull-down assay. Results Expression of circHIPK2 and CHTOP was upregulated, and miR-338-3p was downregulated in human DDP-resistant OvCa tumors and cells. Blocking circHIPK2 could promote apoptosis and suppress the 50% inhibitory concentration (IC50) of DDP, cell proliferation, cell cycle entrance, migration and invasion in SKOV3/DDP and A2780/DDP cells. Allied with that was decreased B cell lymphoma (Bcl)-2, matrix metalloproteinase 2 (MMP2) and MMP9 levels, and increased Bcl-2-associated X protein (Bax) level. Similarly, overexpression of miR-338-3p functioned suppressive role in SKOV3/DDP and A2780/DDP cells. MiR-338-3p was a target for circHIPK2, and CHTOP was targeted by miR-338-3p, whereas silencing miR-338-3p counteracted the role of circHIPK2 knockdown, and restoring CHTOP either cancelled miR-338-3p role. The growth of A2780/DDP cells in nude mice was restrained by silencing circHIPK2 under DDP treatment or not. Conclusion CircHIPK2 might be a tumor promoter in OvCa and was associated with DDP resistance. Silencing circHIPK2 might suppress DDP-resistant OvCa through regulating miR-338-3p/CHTOP axis.
16 citations
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TL;DR: A new trace alkaloid possessing the lignan structure, named oleraisoindole A, was obtained from the extract of the Portulaca oleracea L using high resolution electrospray ionization time-of-flight mass spectroscopic methods.
16 citations
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TL;DR: The area under the concentration–time curve and the peak concentration of larotaxel seemed to increase with increasing dose proportionally, suggesting linear pharmacokinetics.
Abstract: A UPLC-ESI-MS/MS method has been developed and validated for the determination of larotaxel in beagle dog plasma. After addition of the internal standard, plasma samples were extracted by liquid–liquid extraction with methyl tert-butyl ether and separated on a 50 × 2.1 mm ACQUITY 1.7 μm C18 column (Waters, USA), with acetonitrile and 5 mM ammonium acetate as mobile phase, within a runtime of 3.0 min. The analytes were detected without interference in Multiple Reaction Monitoring mode with positive electrospray ionization. The linear range was 2.5–5,000 ng/mL. The intra-day and inter-day precisions (relative standard deviation, RSD, %) were within 9.3% and 10.2%, respectively, and the accuracy (relative error, RE, %) was less than 11.5%. The validated method was successfully applied to a pharmacokinetic study of larotaxel in beagle dogs after intravenous administration of larotaxel-loaded lipid microsphere with different doses of 0.4, 0.8, and 1.6 mg/kg. The area under the concentration–time curve and the peak concentration of larotaxel seemed to increase with increasing dose proportionally, suggesting linear pharmacokinetics.
16 citations
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TL;DR: Three novel compounds, together with five known ingredients, octacosanol, 3′,4′,5-trihydroxy-3,7-dimethoxyflavone, 3,4-dihydroxybenzaldehyde, isorhamnetin, and ent-kaurane-3β,16β,17-triol were obtained from the leaves of Smallanthus sonchifolius (yacon).
16 citations
Authors
Showing all 2045 results
Name | H-index | Papers | Citations |
---|---|---|---|
Hang Xiao | 64 | 618 | 16026 |
Muhammad Riaz | 58 | 934 | 15927 |
Jianping Liu | 45 | 333 | 7977 |
Guoan Luo | 45 | 221 | 6358 |
Xingshun Qi | 40 | 308 | 5409 |
Mei Wang | 29 | 201 | 6007 |
Xiaozhong Guo | 28 | 142 | 2269 |
Zhiwei Cao | 27 | 110 | 2879 |
Xinggang Yang | 26 | 113 | 2292 |
Ruixin Zhu | 25 | 110 | 2119 |
Ran Wang | 23 | 157 | 1942 |
Li-Ping Bai | 22 | 95 | 1824 |
Ke Liu | 19 | 31 | 1183 |
Ahmed M. Metwaly | 17 | 51 | 682 |
Kailin Tang | 17 | 40 | 919 |