Institution
Max Planck Society
Nonprofit•Munich, Germany•
About: Max Planck Society is a nonprofit organization based out in Munich, Germany. It is known for research contribution in the topics: Galaxy & Population. The organization has 148289 authors who have published 406224 publications receiving 19522268 citations. The organization is also known as: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e. V. & MPG.
Topics: Galaxy, Population, Star formation, Stars, Magnetic field
Papers published on a yearly basis
Papers
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Max Planck Society1, University of Innsbruck2, Centre national de la recherche scientifique3, ETH Zurich4, Stockholm University5, Oeschger Centre for Climate Change Research6, Tuscia University7, Potsdam Institute for Climate Impact Research8, University of Aberdeen9, International Institute for Applied Systems Analysis10, University of Antwerp11, University of Potsdam12
TL;DR: The mechanisms and impacts of climate extremes on the terrestrial carbon cycle are explored, and a pathway to improve the understanding of present and future impacts ofClimate extremes onThe terrestrial carbon budget is proposed.
Abstract: The terrestrial biosphere is a key component of the global carbon cycle and its carbon balance is strongly influenced by climate. Continuing environmental changes are thought to increase global terrestrial carbon uptake. But evidence is mounting that climate extremes such as droughts or storms can lead to a decrease in regional ecosystem carbon stocks and therefore have the potential to negate an expected increase in terrestrial carbon uptake. Here we explore the mechanisms and impacts of climate extremes on the terrestrial carbon cycle, and propose a pathway to improve our understanding of present and future impacts of climate extremes on the terrestrial carbon budget.
1,290 citations
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TL;DR: A global survey of messenger RNA splicing events identified 94,241 splice junctions and showed that exon skipping is the most prevalent form of alternative splicing.
Abstract: The functional complexity of the human transcriptome is not yet fully elucidated. We report a high-throughput sequence of the human transcriptome from a human embryonic kidney and a B cell line. We used shotgun sequencing of transcripts to generate randomly distributed reads. Of these, 50% mapped to unique genomic locations, of which 80% corresponded to known exons. We found that 66% of the polyadenylated transcriptome mapped to known genes and 34% to nonannotated genomic regions. On the basis of known transcripts, RNA-Seq can detect 25% more genes than can microarrays. A global survey of messenger RNA splicing events identified 94,241 splice junctions (4096 of which were previously unidentified) and showed that exon skipping is the most prevalent form of alternative splicing.
1,288 citations
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TL;DR: It is shown here that functional integrins do not contribute to migration in three-dimensional environments, and these cells migrate by the sole force of actin-network expansion, which promotes protrusive flowing of the leading edge.
Abstract: All metazoan cells carry transmembrane receptors of the integrin family, which couple the contractile force of the actomyosin cytoskeleton to the extracellular environment In agreement with this principle, rapidly migrating leukocytes use integrin-mediated adhesion when moving over two-dimensional surfaces As migration on two-dimensional substrates naturally overemphasizes the role of adhesion, the contribution of integrins during three-dimensional movement of leukocytes within tissues has remained controversial We studied the interplay between adhesive, contractile and protrusive forces during interstitial leukocyte chemotaxis in vivo and in vitro We ablated all integrin heterodimers from murine leukocytes, and show here that functional integrins do not contribute to migration in three-dimensional environments Instead, these cells migrate by the sole force of actin-network expansion, which promotes protrusive flowing of the leading edge Myosin II-dependent contraction is only required on passage through narrow gaps, where a squeezing contraction of the trailing edge propels the rigid nucleus
1,288 citations
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TL;DR: Co-culture studies with neonatal myocytes indicate that isl1+ cells represent authentic, endogenous cardiac progenitors (cardioblasts) that display highly efficient conversion to a mature cardiac phenotype with stable expression of myocytic markers in the absence of cell fusion, intact Ca2+-cycling, and the generation of action potentials.
Abstract: The purification, renewal and differentiation of native cardiac progenitors would form a mechanistic underpinning for unravelling steps for cardiac cell lineage formation, and their links to forms of congenital and adult cardiac diseases. Until now there has been little evidence for native cardiac precursor cells in the postnatal heart. Herein, we report the identification of isl1+ cardiac progenitors in postnatal rat, mouse and human myocardium. A cardiac mesenchymal feeder layer allows renewal of the isolated progenitor cells with maintenance of their capability to adopt a fully differentiated cardiomyocyte phenotype. Tamoxifen-inducible Cre/lox technology enables selective marking of this progenitor cell population including its progeny, at a defined time, and purification to relative homogeneity. Co-culture studies with neonatal myocytes indicate that isl1+ cells represent authentic, endogenous cardiac progenitors (cardioblasts) that display highly efficient conversion to a mature cardiac phenotype with stable expression of myocytic markers (25%) in the absence of cell fusion, intact Ca2+-cycling, and the generation of action potentials. The discovery of native cardioblasts represents a genetically based system to identify steps in cardiac cell lineage formation and maturation in development and disease.
1,286 citations
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TL;DR: In this article, a simple method to control catechol-Fe3+ interpolymer cross-linking via pH was developed, inspired by the pH jump experienced by proteins during maturation of a mussel byssus secretion, and the resonance Raman signature was similar to that from native mussel thread cuticle and the gels displayed elastic moduli that approach covalently crosslinked gels as well as self-healing properties.
Abstract: Growing evidence supports a critical role of metal-ligand coordination in many attributes of biological materials including adhesion, self-assembly, toughness, and hardness without mineralization [Rubin DJ, Miserez A, Waite JH (2010) Advances in Insect Physiology: Insect Integument and Color, eds Jerome C, Stephen JS (Academic Press, London), pp 75–133]. Coordination between Fe and catechol ligands has recently been correlated to the hardness and high extensibility of the cuticle of mussel byssal threads and proposed to endow self-healing properties [Harrington MJ, Masic A, Holten-Andersen N, Waite JH, Fratzl P (2010) Science 328:216–220]. Inspired by the pH jump experienced by proteins during maturation of a mussel byssus secretion, we have developed a simple method to control catechol-Fe3+ interpolymer cross-linking via pH. The resonance Raman signature of catechol-Fe3+ cross-linked polymer gels at high pH was similar to that from native mussel thread cuticle and the gels displayed elastic moduli (G′) that approach covalently cross-linked gels as well as self-healing properties.
1,286 citations
Authors
Showing all 148365 results
Name | H-index | Papers | Citations |
---|---|---|---|
Ronald C. Kessler | 274 | 1332 | 328983 |
Albert Hofman | 267 | 2530 | 321405 |
Graham A. Colditz | 261 | 1542 | 256034 |
Michael Grätzel | 248 | 1423 | 303599 |
Guido Kroemer | 236 | 1404 | 246571 |
George Davey Smith | 224 | 2540 | 248373 |
Matthias Mann | 221 | 887 | 230213 |
Yi Chen | 217 | 4342 | 293080 |
Eric N. Olson | 206 | 814 | 144586 |
Ronald M. Evans | 199 | 708 | 166722 |
Hans Clevers | 199 | 793 | 169673 |
Raymond J. Dolan | 196 | 919 | 138540 |
David J. Schlegel | 193 | 600 | 193972 |
Simon D. M. White | 189 | 795 | 231645 |
George Efstathiou | 187 | 637 | 156228 |