Showing papers by "Ming Chuan University published in 2017"

An exploration of online behaviour engagement and achievement in flipped classroom supported by learning management system

Abstract: How to promote engagement and achievement in flipped classroom has been a critical research issue. It has been recognized that a course design enticing students' behaviour, emotional and cognitive engagements could promote achievement. Among the different types of engagements, behaviour engagement is relatively easier to measure and collect, especially with the help of learning management systems (LMS). This study focuses on the exploration of how online behaviour engagement affects achievement in flipped classroom with a problem-centered learning flow consisting of activation, demonstration, application, and integration. Learning data collected from ten courses was analysed. All the courses were conducted on the Moodle platform, with a total of 488 undergraduate students enrolled from 2010 to 2015Â at a university in Taiwan. A model depicting how online behaviour engagement affects achievement was developed using the partial least squares SEM (PLS-SEM) method. Findings demonstrate that engagement in problem-solving activities has a significant effect on achievement. Furthermore, engagement in self-assessment and self-reflection activities have a significant direct effect on engagement in online studies and social interaction, which in turn have a significant direct effect on engagement in problem-solving activities. Most important of all, the effect of the engagement in self-assessment and self-reflection on achievement is mediated by the engagement in problem-solving activities. Based on these findings, it is argued that the design of attractive and progressive problem-solving activities is at the heart of an effective flipped classroom, and promoting a learning culture of self-reflection and self-assessment helps trigger active engagements in other online learning activities.

Effects of Different Types of Exercise on Body Composition, Muscle Strength, and IGF-1 in the Elderly with Sarcopenic Obesity.

Abstract: Objectives To investigate the influence of resistance training (RT), aerobic training (AT), or combination training (CT) interventions on the body composition, muscle strength performance, and insulin-like growth factor 1 (IGF-1) of patients with sarcopenic obesity. Design Randomized controlled trial. Setting Community center and research center. Participants Sixty men and women aged 65–75 with sarcopenic obesity. Intervention Participants were randomly assigned to RT, AT, CT, and control (CON) groups. After training twice a week for 8 weeks, the participants in each group ceased training for 4 weeks before being examined for the retention effects of the training interventions. Measurements The body composition, grip strength, maximum back extensor strength, maximum knee extensor muscle strength, and blood IGF-1 concentration were measured. Results The skeletal muscle mass (SMM), body fat mass, appendicular SMM/weight %, and visceral fat area (VFA) of the RT, AT, and CT groups were significantly superior to those of the CON group at both week 8 and week 12. Regarding muscle strength performance, the RT group exhibited greater grip strength at weeks 8 and 12 as well as higher knee extensor performance at week 8 than that of the other groups. At week 8, the serum IGF-1 concentration of the RT group was higher than the CON group, whereas the CT group was superior to the AT and CON groups. Conclusion Older adults with sarcopenic obesity who engaged in the RT, AT, and CT interventions demonstrated increased muscle mass and reduced total fat mass and VFA compared with those without training. The muscle strength performance and serum IGF-1 level in trained groups, especially in the RT group, were superior to the control group.

Toward Sustainable Livelihoods: Investigating the Drivers of Purchase Behavior for Green Products

Abstract: Green consumption involves comprehensive concerns that address the broad scope of sustainability, ecosystem balance, profit-generation and people. Identifying the factors that influence consumers' purchase behavior enables manufacturers to understand consumers' decision-making processes and can help them develop more environmentally beneficial products. However, scholars have recently found that a gap exists between environmental concern and consumers' actual purchase behavior. The purpose of this paper is to use cognitive behavior theory to investigate the drivers of green consumption behavior and the missing link in the concern–behavior gap. After collecting 375 valid questionnaires, this study validated the proposed conceptual model using structural equation modeling. The revised model indicates that environmental involvement, informational utility, green advertising skepticism and green trust are antecedent variables of consumer attitudes toward green products. Additionally, this study also provides a possible explanation of and remedies for the concern–behavior gap. Copyright © 2017 John Wiley & Sons, Ltd and ERP Environment

Greenhouse Gas Emissions, Energy Consumption and Economic Growth: A Panel Cointegration Analysis for 16 Asian Countries

Abstract: This research investigates the co-movement and causality relationships between greenhouse gas emissions, energy consumption and economic growth for 16 Asian countries over the period 1990-2012. The empirical findings suggest that in the long run, bidirectional Granger causality between energy consumption, GDP and greenhouse gas emissions and between GDP, greenhouse gas emissions and energy consumption is established. A non-linear, quadratic relationship is revealed between greenhouse gas emissions, energy consumption and economic growth, consistent with the environmental Kuznets curve for these 16 Asian countries and a subsample of the Asian new industrial economy. Short-run relationships are regionally specific across the Asian continent. From the viewpoint of energy policy in Asia, various governments support low-carbon or renewable energy use and are reducing fossil fuel combustion to sustain economic growth, but in some countries, evidence suggests that energy conservation might only be marginal.

Renewable energy, carbon emissions, and economic growth in 24 Asian countries: evidence from panel cointegration analysis

Abstract: This article aims to investigate the relationship among renewable energy consumption, carbon dioxide (CO2) emissions, and GDP using panel data for 24 Asian countries between 1990 and 2012. Panel cross-sectional dependence tests and unit root test, which considers cross-sectional dependence across countries, are used to ensure that the empirical results are correct. Using the panel cointegration model, the vector error correction model, and the Granger causality test, this paper finds that a long-run equilibrium exists among renewable energy consumption, carbon emission, and GDP. CO2 emissions have a positive effect on renewable energy consumption in the Philippines, Pakistan, China, Iraq, Yemen, and Saudi Arabia. A 1% increase in GDP will increase renewable energy by 0.64%. Renewable energy is significantly determined by GDP in India, Sri Lanka, the Philippines, Thailand, Turkey, Malaysia, Jordan, United Arab Emirates, Saudi Arabia, and Mongolia. A unidirectional causality runs from GDP to CO2 emissions, and two bidirectional causal relationships were found between CO2 emissions and renewable energy consumption and between renewable energy consumption and GDP. The findings can assist governments in curbing pollution from air pollutants, execute energy conservation policy, and reduce unnecessary wastage of energy.

Impacts of misbehaving air passengers on frontline employees: role stress and emotional labor

Abstract: Purpose The study aimed to investigate the impact of customer misbehaviors on airline in-flight customer contact personnel A theoretical framework was proposed to test the meditating role of role stress and emotional labor in the relationship between consumer misbehaviors and emotional exhaustion Design/methodology/approach In all, 336 cabin crew members employed by international airline companies participated in the study The hypothesized model was tested using structural equation modeling with AMOS 200 Findings The results provide evidence that customer misbehaviors relate positively to employee role stress, emotional labor and emotional exhaustion Moreover, role stress and emotional labor play important roles in enhancing the impacts of customer misbehaviors and thereby influence employee emotional exhaustion Practical implications The findings potentially impact on employers both within and beyond the airline industry by demonstrating how frontline employees can be provided with support to reduce stress or exhaustion, leading ultimately to increased satisfaction Originality/value This study has provided deeper theoretical insights into customer misbehaviors and their effects on employee role stress, emotional labor and emotional exhaustion

Moderating and mediating roles of environmental concern and ecotourism experience for revisit intention

Abstract: Purpose This study aims to provide novel insights via a joint investigation of the mediating role of environmental concern and ecotourism experiences It further explores environmental concern and image as moderators of the association between tourists’ ecotourism experience and revisit intention Design/methodology/approach The study used a three-way framework which provided novelty ways of combined moderation-mediation tests on a sample of 474 foreign tourists Findings Results show that environmental concern and ecotourism experience mediated the relationships between motivation and revisit intention The moderating test shows that foreign tourists’ revisit intention and ecotourism experience are highest when environmental concern and image are high Practical implications Results of this study suggest that it may be beneficial to relate resources of tourism’s organization to prepare for potential sustainable requirements and/or to assist tourists to develop positive pro-environment attitudes (such as inspire tourists’ sense of social responsibility to improve environmental quality), which could possibly improve the feelings about the natural environment as serving the public good and may raise concern about environmental protection reasonability for tourists Originality/value This research is the first comprehensive examination of foreign tourists’ pro-environment attitudes and conducts three-way interaction between tourists’ ecotourism experience, image and environmental concern, which may provide a benchmark for future studies

Intestinal microbiome in children with severe and complicated acute viral gastroenteritis.

Abstract: The aim of the present study was to evaluate the microbiota of children with severe or complicated acute viral gastroenteritis (AGE). To that end, next-generation sequencing (NGS) technology was used to sequence the 16S ribosomal RNA (16S rRNA) gene in 20 hospitalized pediatric patients with severe or complicated AGE and a further 20 otherwise healthy children; the fecal microbiome was then assessed. Comparative metagenomics data were analyzed by a Wilcoxon rank–sum test and hierarchical clustering analysis of bacterial reads. The statistical analyses showed a significantly decreased Shannon diversity index (entropy score) of the intestinal microbiota in patients with severe AGE compared with normal controls (P = 0.017) and patients with mild-to-moderate AGE (P = 0.011). The intestinal microbiota score of the 5 patients with rotavirus AGE was significantly lower than that of those with norovirus infection (P = 0.048). Greater richness in Campylobacteraceae (P = 0.0003), Neisseriaceae (P = 0.0115), Methylobacteriaceae (P = 0.0004), Sphingomonadaceae (P = 0.0221), and Enterobacteriaceae (P = 0.0451) was found in patients with complicated AGE compared with normal controls. The data suggest a significant reduction in intestinal microbial diversity in patients with severe AGE, particularly those with rotavirus infection.

Blockchain-based payment collection supervision system using pervasive Bitcoin digital wallet

Abstract: After years of tremendous development and research in digital currency, the most famous Bitcoin industry chain has been gradually completed including mining, exchange, currency exchange, ATM, pervasive digital wallet design and so on. Especially, its blockchain technology has become FinTech organizations' emerging business and research directions, also been applied in the interdisciplinary medical science, supply chain and Internet of things. Digitizing currency can solve many problems in physical currency, such as the rampant counterfeit banknotes. Thus, not only the transparency can be cost-effectively preserved in store's ledger, but also customer's rights and interests can be protected while using the digital wallet. For the government, the regulation and auditing of financial transaction can be made simpler and more convenient for tax collection issue. Digitized transaction details can be much easier to audit by any computing device than manually audit the conventional ledger books. Furthermore, to make merchandise store to use digitized currency much easier, in this paper, we propose and deploy a Bitcoin collection supervision system called BPCSS based on blockchain technology with cloud databases for customers and merchandise stores. The preliminary experimental results via the well-known pervasive digital wallet of Testnet Bitcoin demonstrate the proposed BPCSS can cost-effectively collect payment and supervise the transactions between customer and merchandise store running the implemented NFC-enabled Android Apps.

Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling

Abstract: The bioflavonoid apigenin has been shown to possess cancer-preventive and anti-cancer activities. In a drug screening, we found that apigenin can inhibit Wnt/β-catenin signaling, a pathway that participates in pivotal biological functions, which dis-regulation results in various human diseases including cancers. However, the underlying mechanism of apigenin in this pathway and its link to anti-cancer activities remain largely unknown. Here we showed that apigenin reduced the amount of total, cytoplasmic, and nuclear β-catenin, leading to the suppression in the β-catenin/TCF-mediated transcriptional activity, the expression of Wnt target genes, and cell proliferation of Wnt-stimulated P19 cells and Wnt-driven colorectal cancer cells. Western blotting and immunofluorescent staining analyses further revealed that apigenin could induce autophagy-mediated down-regulation of β-catenin in treated cells. Treatment with autophagy inhibitors wortmannin and chloroquine compromised this effect, substantiating the involvement of autophagy-lysosomal system on the degradation of β-catenin during Wnt signaling through inhibition of the AKT/mTOR signaling pathway. Our data not only pointed out a route for the inhibition of canonical Wnt signaling through the induction of autophagy-lysosomal degradation of key player β-catenin, but also suggested that apigenin or other treatments which can initiate this degradation event are potentially used for the therapy of Wnt-related diseases including cancers.

The Moderating Effects of Students' Personality Traits on Pro-Environmental Behavioral Intentions in Response to Climate Change.

Abstract: This study developed a model that examined the relationship between undergraduate students’ beliefs, norms and pro-environment behavioral intentions in the context of global climate change (GCC). The model was further evaluated to determine whether latent variables, such as sustainability value, environmental concern, social norms, perceived risk, pro-environmental attitude, as defined by the theory of planned behavior and value-belief-norm theory, significantly influenced students’ intentions towards pro-environmental behavior. The research model was empirically tested using data collected form 275 undergraduate students. Empirical results found support for four interaction effects of personality traits and the related latent variables of environmental attitude, including sustainability value, social norms, environmental concern and perceived risk. The impact of undergraduate students’ environmental attitudes was moderated by personality traits. The findings of this research offer policy makers and enterprises better understandings of undergraduate students’ attitudes and behavioral intentions towards GCC and promote the visibility of this issue.

Blue light induced reactive oxygen species from flavin mononucleotide and flavin adenine dinucleotide on lethality of HeLa cells.

Abstract: Photodynamic therapy (PDT) is a safe and non-invasive treatment for cancers and microbial infections. Various photosensitizers and light sources have been developed for clinical cancer therapies. Flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) are the cofactor of enzymes and are used as photosensitizers in this study. Targeting hypoxia and light-triggering reactive oxygen species (ROS) are experimental strategies for poisoning tumor cells in vitro. HeLa cells are committed to apoptosis when treated with FMN or FAD and exposed to visible blue light (the maximum emitted wavelength of blue light is 462nm). Under blue light irradiation at 3.744J/cm2 (=0.52mW/cm2 irradiated for 2h), the minimal lethal dose is 3.125μM and the median lethal doses (LD50) for FMN and FAD are 6.5μM and 7.2μM, respectively. Individual exposure to visible blue light irradiation or riboflavin photosensitizers does not produce cytotoxicity and no side effects are observed in this study. The western blotting results also show that an intrinsic apoptosis pathway is activated by the ROS during photolysis of riboflavin analogues. Blue light triggers the cytotoxicity of riboflavins on HeLa cells in vitro. Based on these results, this is a feasible and efficient of PDT with an intrinsic photosensitizer for cancer research.

The Effects of Writing Anxiety and Motivation on EFL College Students’ Self-Evaluative Judgments of Corrective Feedback:

Abstract: Feedback is regarded as a way to foster students' motivation and to ensure linguistic accuracy. However, mixed findings are reported in the research on written corrective feedback because of its multifaceted nature and its correlations with learners' individual differences. It is necessary, therefore, to conduct further research on corrective feedback from the student's perspective and to examine how individual differences in terms of factors such as writing anxiety and motivation predict learners' self-evaluative judgments of both teacher-corrected and peer-corrected feedback. For this study, 158 Taiwanese college sophomores participated in a survey that comprised three questionnaires. Results demonstrated that intrinsic motivation and different types of writing anxiety predicted English as foreign language learners' evaluative judgments of teacher and peer feedback. The findings have implications for English-writing instruction.

Expression of Neuroendocrine Factor VGF in Lung Cancer Cells Confers Resistance to EGFR Kinase Inhibitors and Triggers Epithelial-to-Mesenchymal Transition.

Abstract: Mutations in EGFR drive tumor growth but render tumor cells sensitive to treatment with EGFR tyrosine kinase inhibitors (TKI). Phenotypic alteration in epithelial-to-mesenchymal transition (EMT) has been linked to the TKI resistance in lung adenocarcinoma. However, the mechanism underlying this resistance remains unclear. Here we report that high expression of a neuroendocrine factor termed VGF induces the transcription factor TWIST1 to facilitate TKI resistance, EMT, and cancer dissemination in a subset of lung adenocarcinoma cells. VGF silencing resensitized EGFR-mutated lung adenocarcinoma cells to TKI. Conversely, overexpression of VGF in sensitive cells conferred resistance to TKIs and induced EMT, increasing migratory and invasive behaviors. Correlation analysis revealed a significant association of VGF expression with advanced tumor grade and poor survival in patients with lung adenocarcinoma. In a mouse xenograft model of lung adenocarcinoma, suppressing VGF expression was sufficient to attenuate tumor growth. Overall, our findings show how VGF can confer TKI resistance and trigger EMT, suggesting its potential utility as a biomarker and therapeutic target in lung adenocarcinoma. Cancer Res; 77(11); 3013-26. ©2017 AACR.

Digital Noninverting-Buck–Boost Converter With Enhanced Duty-Cycle-Overlap Control

Abstract: The nonideal effects of the comparator and dead time in a synchronous controlled dc-dc converter adversely affect the stability of a four-switch noninverting-buck–boost (NIBB) converter. The pulse-skipping phenomenon occurs in the mode-transition region near the boundary between the step-down and step-up regions, and this phenomenon leads to an unstable output voltage and an unpredictable output voltage ripple. However, these two results may damage the entire power system and application system. This brief proposes an enhanced duty-cycle-overlap control technique for a digitally controlled NIBB converter. The proposed technique offers two duty cycle limitations for various conditions in the mode-transition region and ensures the stability of the digital controller and output voltage. Moreover, this technique involves combining the duty cycles of both step-down and step-up modes for deriving an accurate value of the output voltage. The experimental results derived from a digital controller implemented through a field-programmable-gate-array-based platform revealed that the output voltage of the NIBB converter was stable throughout the transition region. The observed input voltage of the converter, provided by a Li-ion battery, was 2.5–4.5 V, and the output voltage was typically 3.3 V, which is suitable for communication systems, audio systems, and I/O pad power supplies. The switching frequency was 1 MHz, and the maximum load current was 500 mA.

Industrial tourists' behavioral intention toward slow travel in Taiwan

Abstract: Taiwan has experienced rapid growth in the last decade, especially in the number of international tourists and domestic leisure travelers it receives. In response to pressures to minimize the negative environmental impacts of such visits (i.e. greenhouse gas emissions) and reshape the notion of sustainable destinations, since 2010 the concept of slow travel has been promoted by governments and the tourism industry. Consequently, calls to expand programs connecting various destinations (e.g. the establishment of industrial tourism) using slower modes of transportation have begun to emerge. In an effort to elucidate the key factors that motivate a traveler's intention to engage in slow travel, this study has constructed a research model that incorporates slow travel's three core elements: the mode of slow travel, tourism experience and environmental consciousness. Particularly, this study has focused on industrial tourists who typically rely on cars to reach destinations that have become new tourism...

Antitumor properties of Coenzyme Q0 against human ovarian carcinoma cells via induction of ROS-mediated apoptosis and cytoprotective autophagy

Abstract: Coenzyme Q0 (CoQ0, 2,3-dimethoxy-5-methyl-1,4-benzoquinone) has been reported to exert anticancer properties against human breast/lung cancer cells. This study investigated the in vitro and in vivo anticancer properties of CoQ0 on human ovarian carcinoma (SKOV-3) cells and xenografted nude mice, and revealed the underlying molecular mechanism. CoQ0 induced G2/M arrest through downregulation of cyclin B1/A and CDK1/K2 expressions. CoQ0-induced autophagy as a survival mechanism was evidenced by increased accumulation of LC3-II, GFP-LC3 puncta, AVOs formation and Beclin-1/Bcl-2 dysregulation. Increased TUNEL-positive cells and Annexin-V/PI stained cells indicated CoQ0-induced late apoptosis. Both mitochondrial (caspase-3, PARP and Bax/Bcl-2 dysregulation) and ER stress (caspase-12 and Hsp70) signals are involved in execution of apoptosis. Interestingly, CoQ0-induced apoptosis/autophagy is associated with suppression of HER-2/neu and PI3K/AKT signalling cascades. CoQ0 triggered intracellular ROS production, whereas antioxidant N-acetylcysteine prevented CoQ0-induced apoptosis, but not autophagy. Inhibition of apoptosis by Z-VAD-FMK suppressed CoQ0-induced autophagy (diminished LC3-II/AVOs), indicates CoQ0-induced apoptosis led to evoke autophagy. Contrary, inhibition of autophagy by 3-MA/CQ potentiated CoQ0-induced apoptosis (increased DNA fragmentation/PARP cleavage). Furthermore, CoQ0 treatment to SKOV-3 xenografted nude mice reduced tumor incidence and burden. Histopathological analyses confirmed that CoQ0 modulated xenografted tumor progression by apoptosis induction. Our findings emphasize that CoQ0 triggered ROS-mediated apoptosis and cytoprotective autophagy.